Effects of carrier release kinetics on bone morphogenetic protein-2-induced periodontal regeneration in vivo

Journal of Clinical Periodontology

Volumn 28, Issue 4, 2001, Pages 340-347

  Talwar, Richard ^a   Di Silvio, Lucy ^b   Hughes, Francis J ^a   King, Gaston N ^a  

^a QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^b Institute of Orthopaedics   (United Kingdom)

Author keywords

Bone morphogenetic protein; Drug delivery; Drug release kinetics; Gelatin; Periodontal regeneration; Wound healing

Indexed keywords

BMP2 PROTEIN, HUMAN; BMP2 PROTEIN, RAT; BONE MORPHOGENETIC PROTEIN; BONE MORPHOGENETIC PROTEIN 2; DRUG CARRIER; RECOMBINANT HUMAN BONE MORPHOGENETIC PROTEIN 2; RECOMBINANT HUMAN BONE MORPHOGENETIC PROTEIN-2; RECOMBINANT PROTEIN; TRANSFORMING GROWTH FACTOR BETA;

ANALYSIS OF VARIANCE; ANIMAL; ARTICLE; BONE DEVELOPMENT; CEMENTUM; COMPARATIVE STUDY; DELAYED RELEASE FORMULATION; DRUG EFFECT; DRUG IMPLANT; GEL; HUMAN; IMAGE PROCESSING; JAW; KINETICS; MALE; OSTEOLYSIS; PATHOLOGY; PERIODONTAL DISEASE; RAT; REGENERATION; STATISTICS; TREATMENT OUTCOME; WISTAR RAT; WOUND HEALING;

ALVEOLAR BONE LOSS; ALVEOLAR PROCESS; ANALYSIS OF VARIANCE; ANIMALS; BONE MORPHOGENETIC PROTEINS; DELAYED-ACTION PREPARATIONS; DENTAL CEMENTUM; DRUG CARRIERS; DRUG IMPLANTS; GELS; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; KINETICS; MALE; OSTEOGENESIS; PERIODONTAL DISEASES; RATS; RATS, WISTAR; RECOMBINANT PROTEINS; REGENERATION; STATISTICS; TRANSFORMING GROWTH FACTOR BETA; TREATMENT OUTCOME; WOUND HEALING;

EID: 0035319688     PISSN: 03036979     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1600-051x.2001.028004340.x     Document Type: Article

References (25)

1. Andersson, L., Lindskog, S., Blomlof, L., Hedstrom, K.-G. & Hammarström, L. (1985) Effect of masticatory stimulation on dentoalveolar ankylosis after experimental tooth replantation. Endodontics and Dental Traumatology 1, 13-16.
2. Andreasen, J. O. (1985) External root resorptions: its implication in dental traumatology, paedodontics, periodontics, orthodontics and endodontics. International Journal of Endodontics 8, 109-118.
3. Bradbury, P. & Gordon, K. C. (1990) Connective tissues and stains. In: Theory and practice of histological techniques. Bancroft J D, Stevens A (eds): Edinburgh: Churchill Livingstone, p. 132.
4. Di Silvio, L., Kayser, M. V. & Downes, S. (1994a) Validation and optimisation of a polymer system for potential use as a controlled drug-delivery system. Clinical Materials 16, 91-98.
5. Di Silvio, L., Courtney-Harris, R. G. & Downes, S. (1994b) The use of gelatin as a vehicle for drug and peptide delivery. Journal of Material Science: Materials in Medicine 5, 819-823.
6. Di Silvio, L., Gurav, N., Kayser, M. V., Braden, M. & Downes, S. (1994c) Biodegradable microspheres: a new delivery system for growth hormone. Biomaterials 15, 931-936.
7. Giannoble, W. V., Ryan, S., Shih, M.-.S, Su, D. L., Kaplan, P. L. & Chan, T. C. K. (1998) Recombinant human osteogenic protein-1 (OP-1) stimulates periodontal wound healing in Class III furcation defects. Journal of Periodontology 69, 129-137.
8. Heasman, P., Soskolne, A., Smart, G. & Newman H. (1995) Subgingival administration of Periochips in patients with chronic periodontitis (IADR abstract).
9. Howell, T. H., Martuscelli, G. & Oringer, R. J. (1996) Polypeptide growth factors for periodontal regeneration. Current Opinion in Periodontology 3, 149-156.
10. Jeyanthi, R. & Rao, K. P. (1987) Preparation of gelatin microspheres of bleomycin. International Journal of Pharmaceutics 35, 177-179.
11. King, G. N., King, N., Cruchley, A. T., Wozney, J. M. & Hughes, F. J. (1997) Recombinant human bone morphogenetic protein-2 promotes wound healing in rat periodontal fenestration defects. Journal of Dental Research 76, 1460-1470.
12. King, G. N., King, N. & Hughes, F. J. (1998a) The effect of root surface demineralisation on bone morphogenetic protein-2-induced healing of rat periodontal fenestration defects. Journal of Periodontology 69, 561-570.
13. King, G. N., King, N. & Hughes, F. J. (1998b) Effect of two delivery systems for recombinant human bone morphogenetic protein-2 on periodontal regeneration in vivo. Journal of Periodontal Research 33, 226-236.
14. King, G. N. & Hughes, F. J. (1999) Effects of occlusal loading on ankylosis, bone and cementum formation during bone morphogenetic protein-2-stimulated periodontal regeneration in vivo. Journal of Periodontology 70: 1125-1135.
15. Kinoshita, A., Shigeru, O., Takakashi, K., Yokota, S. & Ishikawa, I. (1997) Periodontal regeneration by application of recombinant human bone morphogenetic protein-2 to horizontal circumferential defects created by experimental periodontitis in beagle dogs. Journal of Periodontology 68, 103-109.
16. McCulloch, C. A. G., Nemeth, E., Lowenberg, B. & Melcher, A. H. (1987) Paravascular cells in endosteal spaces of alveolar bone contribute to periodontal ligament cell populations. The Anatomical Record 219, 2233-2242.
17. Melcher, A. H. (1976) On the repair potential of periodontal tissues. Journal of Periodontology 47, 256-260.
18. Narayani, R. & Rao, K. P. (1994) Controlled release of anti-cancer drug methotrexate from biodegradable gelatin microspheres. Journal of Microencapsulation 11, 69-77.
19. Nyman, S., Karring, T., Lindhe, J. & Planten, S. (1980) Healing following implantation of periodontitis affected roots into gingival connective tissue. Journal of Clinical Periodontology 7, 394-401.
20. Ripamonti, U., Heliotis, M., Van den Heever, B. & Reddi, A. H. (1994) Bone morphogenetic proteins induce periodontal regeneration in the baboon (Papio ursinus). Journal of Periodontal Research 29, 439-445.
21. Sigurdsson, T. J., Lee, M. B., Kubota, K., Turek, T. J., Wozney, J. M. & Wikesjö, U. M. E. (1995) Periodontal repair in dogs: Recombinant human bone morphogenetic protein-2 significantly enhances periodontal regeneration. Journal of Periodontology 66, 131-138.
22. Tamada, J. & Langer, R. (1992) A review. The development of polyanhydrides for drug delivery applications. Journal of Biomaterials: Science Polymer Edition 3, 315-353.
23. Wesselink, P. R. & Beertsen, W. (1994) Repair processes in the periodontium following dentoalveolar ankylosis: the effect of masticatory function. Journal of Clinical Periodontology 21, 472-478.
24. Wetterwald, A., Hofstetter, W., Cecchini, M. G., Lanske, B., Wagner, C. & Fleisch, H. (1996) Characterisation and cloning of the E11 antigen, a marker expressed by rat osteoblasts and osteocytes. Bone 18, 125-132.
25. Wikesjö, U. M. E., Nilveus, R. E. & Selvig, K. A. (1992) Significance of early healing events on periodontal repair: A review. Journal of Periodontology 63, 158-165.