Structural determinants for functional coupling between the β and α subunits in the Ca2+-activated K+ (BK) channel

Journal of General Physiology

Volumn 127, Issue 2, 2006, Pages 191-204

  Orio, Patricio ^a,h   Torres, Yolima ^a,b   Rojas, Patricio ^a,c,i   Carvacho, Ingrid ^a,d   Garcia, Maria L ^e   Toro, Ligia ^f   Valverde, Miguel A ^g   Latorre, Ramon ^a,c  

^a CENTRO DE ESTUDIOS CIENTÍFICOS CECS   (Chile)

^b UNIVERSIDAD DEL VALLE   (Colombia)

^c UNIVERSITY OF CHILE   (Chile)

^d UNIVERSIDAD AUSTRAL DE CHILE   (Chile)

^e MERCK RESEARCH LABORATORIES   (United States)

^f UNIVERSITY OF CALIFORNIA   (United States)

^g UNIVERSITAT POMPEU FABRA   (Spain)

^h MIGUEL HERNÁNDEZ UNIVERSITY   (Spain)

ⁱ WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM ACTIVATED POTASSIUM CHANNEL; CALCIUM ACTIVATED POTASSIUM CHANNEL ALPHA; CALCIUM ACTIVATED POTASSIUM CHANNEL BETA; PROTEIN SUBUNIT; UNCLASSIFIED DRUG;

ALPHA CHAIN; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; BETA CHAIN; CARBOXY TERMINAL SEQUENCE; CHIMERA; CONTROLLED STUDY; ELECTROPHYSIOLOGY; NONHUMAN; NUCLEOTIDE SEQUENCE; OOCYTE; PATCH CLAMP; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN STRUCTURE; XENOPUS LAEVIS;

ANIMALS; FEMALE; GENE EXPRESSION; HUMANS; LARGE-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNEL ALPHA SUBUNITS; LARGE-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNEL BETA SUBUNITS; MEMBRANE POTENTIALS; MYOMETRIUM; OOCYTES; PATCH-CLAMP TECHNIQUES; POTASSIUM CHANNELS, VOLTAGE-GATED; PROTEIN STRUCTURE, TERTIARY; STRUCTURE-ACTIVITY RELATIONSHIP; XENOPUS;

EID: 31744439840     PISSN: 00221295     EISSN: 00221295     Source Type: Journal    
DOI: 10.1085/jgp.200509370     Document Type: Article

References (53)

1. 2+ sensitivity is enhanced by its β1 subunit. J. Gen. Physiol. 126:393-412.
2. 2+ sensitivity. J. Gen. Physiol. 120:173-189.
3. 2+ sensing. J. Gen. Physiol. 123:475-489.
4. Behrens, R., A. Nolting, F. Reimann, M. Schwarz, R. Waldschutz, and O. Pongs. 2000. hKCNMB3 and hKCNMB4, cloning and characterization of two members of the large-conductance calcium-activated potassium channel β subunit family. FEBS Lett. 474:99-106.
5. 2+-dependent activation. Proc. Natl. Acad. Sci. USA.98:4776-4781.
6. Brenner, R., T.J. Jegla, A. Wickenden, Y. Liu, and R.W. Aldrich. 2000. Cloning and functional characterization of novel large conductance calcium-activated potassium channel β subunits, hKCNMB3 and hKCNMB4. J. Biol. Chem. 275:6453-6461.
7. Chen, J., J.S. Mitcheson, M. Tristani-Firouzi, M. Lin, and M.C. Sanguinetti. 2001. The S4-S5 linker couples voltage sensing and activation of pacemaker channels. Proc. Natl. Acad. Sci. USA. 98:11277-11282.
8. 2+ sensitivity. J. Gen. Physiol. 116:411-432.
9. + channel. J. Gen. Physiol. 110:257-281.
10. Diaz, L., P. Meera, J. Amigo, E. Stefani, O. Alvarez, L. Toro, and R. Latorre. 1998. Role of the S4 segment in a voltage-dependent calcium-sensitive potassium (hSlo) channel. J. Biol. Chem. 273:32430-32436.
11. Dick, G.M., C.F. Rossow, S. Smirnov, B. Horowitz, and K.M. Sanders. 2001. Tamoxifen activates smooth muscle BK channels through the regulatory β1 subunit. J. Biol. Chem. 276:34594-34599.
12. Dworetzky, S.I., C.G. Boissard, J.T. Lum-Ragan, M.C. McKay, D.J. Post-Munson, J.T. Trojnacki, C.P. Chang, and V.K. Gribkoff. 1996. Phenotypic alteration of a human BK (hSlo) channel by hSlo β subunit coexpression: changes in blocker sensitivity, activation/relaxation and inactivation kinetics, and protein kinase A modulation. J. Neurosci. 16:4543-4550.
13. Fernandez-Fernandez, J.M., M. Tomas, E. Vazquez, P. Orio, R. Latorre, M. Senti, J. Marrugat, and M.A. Valverde. 2004. Gain-offunction mutation in the KCNMB1 potassium channel subunit is associated with low prevalence of diastolic hypertension. J. Clin. Invest. 113:1032-1039.
14. H anner, M., R. Vianna-Jorge, A. Kamassah, W.A. Schmalhofer, H.G. Knaus, G.J. Kaczorowski, and M.L. Garcia. 1998. The β subunit of the high conductance calcium-activated potassium channel. Identification of residues involved in charybdotoxin binding. J. Biol. Chem. 273:16289-16296.
15. 2+ binding and channel opening in large conductance (BK) potassium channels. J. Gen. Physiol. 120:267-305.
16. Horton, R.M., Z.L. Cai, S.N. Ho, and L.R. Pease. 1990. Gene splicing by overlap extension: tailor-made genes using the polymerase chain reaction. Biotechniques. 8:528-535.
17. + channel and demonstration of its presence in the human BK channel. Neuron. 29:593-601.
18. Jiang, Y., A. Lee, J. Chen, M. Cadene, B.T. Chait, and R. MacKinnon. 2002. Crystal structure and mechanism of a calcium-gated potassium channel. Nature. 417:515-522.
19. Jiang, Z., M. Wallner, P. Meera, and L. Toro. 1999. Human and rodent MaxiK channel β-subunit genes: cloning and characterization. Genomics. 55:57-67.
20. Jin, P., T.M. Weiger, Y. Wu, and I.B. Levitan. 2002. Phosphorylationdependent functional coupling of hSlo calcium-dependent potassium channel and its hβ4 subunit. J. Biol. Chem. 277:10014-10020.
21. + channel. Identification of the site of incorporation and implications for channel topology. J. Biol. Chem. 269:23336-23341.
22. + channel from smooth muscle. J. Biol. Chem. 269:17274-17278.
23. 2 terminus of the β3b auxiliary subunit involves a two-step mechanism: possible separation of binding and blockade. J. Gen. Physiol. 117:583-606.
24. + channels. J. Gen. Physiol. 120:663-676.
25. + channels in rat skeletal muscle. J. Physiol. 443:739-777.
26. McManus, O.B., L.M. Helms, L. Pallanck, B. Ganetzky, R. Swanson, and R.J. Leonard. 1995. Functional role of the β subunit of high conductance calcium-activated potassium channels. Neuron. 14:645-650.
27. Meech, R.W. 1978. Calcium-dependent potassium activation in nervous tissues. Annu. Rev. Biophys. Bioeng. 7:1-18.
28. Meera, P., M. Wallner, Z. Jiang, and L. Toro. 1996. A calcium switch for the functional coupling between alpha (hslo) and β subunits (Kv,caβ) of maxi K channels. FEBS Lett. 385:127-128.
29. + channel, a distinct member of voltage-dependent ion channels with seven N-terminal transmembrane segments (S0-S6), an extracellular N terminus, and an intracellular (S9-S10) C terminus. Proc. Natl. Acad. Sci. USA. 94:14066-14071.
30. + channel resistant to charybdotoxin and iberiotoxin. Proc. Natl. Acad. Sci. USA. 97:5562-5567.
31. 2+-independent mechanism. J. Gen. Physiol. 115:719-736.
32. 2+-activated potassium channel. Neuron. 42:745-756.
33. Orio, P., and R. Latorre. 2005. Differential Effects of β1 and β2 subunits on BK channel activity. J. Gen. Physiol. 125:395-411.
34. Orio, P., P. Rojas, G. Ferreira, and R. Latorre. 2002. New disguises for an old channel: maxiK channel β-subunits. News Physiol. Sci. 17:156-161.
35. 2+ sensitivity of BK channels. J. Gen. Physiol. 120:829-843.
36. Schreiber, M., and L. Salkoff. 1997. A novel calcium-sensing domain in the BK channel. Biophys. J. 73:1355-1363.
37. Schreiber, M., A. Yuan, and L. Salkoff. 1999. Transplantable sites confer calcium sensitivity to BK channels. Nat. Neurosci. 2:416-421.
38. Shen, K.Z., A. Lagrutta, N.W. Davies, N.B. Standen, J.P. Adelman, and R.A. North. 1994. Tetraethylammonium block of Slowpoke calcium-activated potassium channels expressed in Xenopus oocytes: evidence for tetrameric channel formation. Pflugers Arch. 426:440-445.
39. Stühmer, W., and A.B. Parekh. 1995. Electrophysiological recordings from Xenopus oocytes. In Single Channel Recording. B. Sakmann and E. Neher, editors. Plenum Press, New York. 341-356.
40. Toro, L., M. Wallner, P. Meera, and Y. Tanaka. 1998. Maxi-K(Ca), a unique member of the voltage-gated K channel superfamily. News Physiol. Sci. 13:112-117.
41. + channels. J. Biol. Chem. 277:18994-19000.
42. + channel. J. Biol. Chem. 275:23211-23218.
43. Valverde, M.A., P. Rojas, J. Amigo, D. Cosmelli, P. Orio, M.I. Bahamonde, G.E. Mann, C. Vergara, and R. Latorre. 1999. Acute activation of Maxi-K channels (hSlo) by estradiol binding to the β subunit. Science. 285:1929-1931.
44. Vergara, C., R. Latorre, N.V. Marrion, and J.P. Adelman. 1998. Calcium-activated potassium channels. Curr. Opin. Neurobiol. 8:321-329.
45. Wallner, M., P. Meera, M. Ottolia, G.J. Kaczorowski, R. Latorre, M.L. Garcia, E. Stefani, and L. Toro. 1995. Characterization of and modulation by a β-subunit of a human maxi KCa channel cloned from myometrium. Receptors Channels. 3:185-199.
46. + channels: an additional transmembrane region at the N terminus. Proc. Natl. Acad. Sci. USA. 93:14922-14927.
47. + channels: a transmembrane β-subunit homolog. Proc. Natl. Acad. Sci. USA. 96:4137-4142.
48. 2+- and voltage-dependent BK channels in adrenal chromaffin cells and rat insulinoma tumor cells. J. Neurosci. 19:5255-5264.
49. 2+-activated, voltage-dependent BK currents: consequences of rapid inactivation by a novel β subunit. J. Neurosci. 20:4890-4903.
50. Xia, X.M., X. Zeng, and C.J. Lingle. 2002. Multiple regulatory sites in large-conductance calcium-activated potassium channels. Nature. 418:880-884.
51. Xia, X.M., X. Zhang, and C.J. Lingle. 2004. Ligand-dependent activation of Slo family channels is defined by interchangeable cytosolic domains. J. Neurosci. 24:5585-5591.
52. 2 and COOH termini. J. Gen. Physiol. 117:607-628.
53. Zeng, X.H., X.M. Xia, and C.J. Lingle. 2003. Redox-sensitive extracellular gates formed by auxiliary β subunits of calcium-activated potassium channels. Nat. Struct. Biol. 10:448-454.