Knowledge-based design of target-focused libraries using protein-ligand interaction constraints

Journal of Medicinal Chemistry

Volumn 49, Issue 2, 2006, Pages 490-500

  Deng, Zhan ^a   Chuaqui, Claudio ^a   Singh, Juswinder ^a  

^a BIOGEN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2,6 DICHLOROBENZYL) 5 (4 FLUORPHENYL) 6 PYRIDIN 4 METHYL 5H PYRIMIDIN 4 ONE; 2 [1,3]DITHIETAN 2 YLIDENE 2 PYRIDIN 4 YL 1 (4 TRIFLUOROMETHOXYPHENYL)ETHANONE; 6 (4 FLUOROPHENYL) 2,3 DIHYDRO 5 (4 PYRIDYL)IMIDAZO[2,1 B]THIAZOLE; IMIDAZOLE DERIVATIVE; MITOGEN ACTIVATED PROTEIN KINASE P38; MITOGEN ACTIVATED PROTEIN KINASE P38 INHIBITOR; PYRIDINE DERIVATIVE; PYRIDINYLIMIDAZOLE DERIVATIVE; PYRIMIDINONE DERIVATIVE; SB 86002; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; COMBINATORIAL LIBRARY; DECISION THEORY; DRUG EFFECT; ENZYME ACTIVE SITE; ENZYME INHIBITION; MOLECULAR INTERACTION; PREDICTION; PROTEIN BINDING; PROTEIN STRUCTURE; STRUCTURAL INTERACTION FINGERPRINT; STRUCTURE ANALYSIS;

BINDING SITES; COMBINATORIAL CHEMISTRY TECHNIQUES; DATABASES, FACTUAL; KNOWLEDGE BASES; LIGANDS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PROTEIN BINDING; PROTEINS; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 31544479320     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm050381x     Document Type: Article

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