메뉴 건너뛰기




Volumn 65, Issue 7, 2005, Pages 585-594

Hyperproinsulinemia segregates young adult patients with newly diagnosed autoimmune (type 1) and non-autoimmune (type 2) diabetes

Author keywords

Diabetes classification; GADA; IA 2A; ICA; Split proinsulin

Indexed keywords

AUTOANTIBODY; INSULIN; ORAL ANTIDIABETIC AGENT; PROINSULIN;

EID: 31544468414     PISSN: 00365513     EISSN: 15027686     Source Type: Journal    
DOI: 10.1080/00365510500261869     Document Type: Article
Times cited : (10)

References (32)
  • 1
    • 1842334456 scopus 로고    scopus 로고
    • Report of the expert committee on the diagnosis and classification of diabetes mellitus
    • American Diabetes Association. Report of the expert committee on the diagnosis and classification of diabetes mellitus. Diabetes Care 1997;20:1183-97.
    • (1997) Diabetes Care , vol.20 , pp. 1183-1197
  • 2
    • 0031851293 scopus 로고    scopus 로고
    • Definition, diagnosis and classification of diabetes mellitus and its complications. I. Diagnosis and classification of diabetes mellitus: Provisional report of a WHO Consultation
    • Alberti KGMM, Zimmet PZ, for the WHO Consultation. Definition, diagnosis and classification of diabetes mellitus and its complications. I. Diagnosis and classification of diabetes mellitus: provisional report of a WHO Consultation. Diabet Med 1998;15:539-53.
    • (1998) Diabet Med , vol.15 , pp. 539-553
    • Alberti, K.G.M.M.1    Zimmet, P.Z.2
  • 4
    • 0035430208 scopus 로고    scopus 로고
    • Autoimmune diabetes not requiring insulin at diagnosis (latent autoimmune diabetes of the adult)
    • Pozzilli P, Di Mario U. Autoimmune diabetes not requiring insulin at diagnosis (latent autoimmune diabetes of the adult). Diabetes Care 2001;24:1460-7.
    • (2001) Diabetes Care , vol.24 , pp. 1460-1467
    • Pozzilli, P.1    Di Mario, U.2
  • 6
    • 0343191485 scopus 로고    scopus 로고
    • High frequency of persisting or increasing islet-specific autoantibody levels after diagnosis of type 1 diabetes presenting before 40 years of age
    • Decochez K, Tits J, Coolens J-L, van Gaal L, Krzentowski G, Winnock F, et al. High frequency of persisting or increasing islet-specific autoantibody levels after diagnosis of type 1 diabetes presenting before 40 years of age. Diabetes Care 2000;23:838-44.
    • (2000) Diabetes Care , vol.23 , pp. 838-844
    • Decochez, K.1    Tits, J.2    Coolens, J.-L.3    Van Gaal, L.4    Krzentowski, G.5    Winnock, F.6
  • 7
    • 0037298967 scopus 로고    scopus 로고
    • Evaluation of the new ADA and WHO criteria for classification of diabetes mellitus in young adult people (15-34 yrs) in the Diabetes Incidence Study in Sweden (DISS)
    • Borg H, Arnqvist HJ, Björk E, Bolinder J, Eriksson JW, Nyström L, et al. Evaluation of the new ADA and WHO criteria for classification of diabetes mellitus in young adult people (15-34 yrs) in the Diabetes Incidence Study in Sweden (DISS). Diabetologia 2003;36:173-81.
    • (2003) Diabetologia , vol.36 , pp. 173-181
    • Borg, H.1    Arnqvist, H.J.2    Björk, E.3    Bolinder, J.4    Eriksson, J.W.5    Nyström, L.6
  • 9
    • 0032955251 scopus 로고    scopus 로고
    • Clinical and genetic characteristics of type 2 diabetes with and without GAD antibodies
    • Tuomi T, Carlsson A, Li H, Isomaa B, Miettinen A, Nilsson A, et al. Clinical and genetic characteristics of type 2 diabetes with and without GAD antibodies. Diabetes 1999;48:150-7.
    • (1999) Diabetes , vol.48 , pp. 150-157
    • Tuomi, T.1    Carlsson, A.2    Li, H.3    Isomaa, B.4    Miettinen, A.5    Nilsson, A.6
  • 10
    • 0034508418 scopus 로고    scopus 로고
    • Glutamic acid decarboxylase antibodies (GADA) is the most important factor for prediction of insulin therapy within 3 years in young adult diabetic patients not classified as type 1 diabetes on clinical grounds
    • Törn C, Landin-Olsson M, Ostman J, Scherstén B, Arnqvist H, Blohmé G, et al. Glutamic acid decarboxylase antibodies (GADA) is the most important factor for prediction of insulin therapy within 3 years in young adult diabetic patients not classified as type 1 diabetes on clinical grounds. Diabetes Metab Res Rev 2000;16:442-7.
    • (2000) Diabetes Metab Res Rev , vol.16 , pp. 442-447
    • Törn, C.1    Landin-Olsson, M.2    Ostman, J.3    Scherstén, B.4    Arnqvist, H.5    Blohmé, G.6
  • 11
    • 0016209121 scopus 로고
    • Circulating proinsulin-like component in man: Increased proportion in hypoinsulinemic states
    • Gordon P, Hendricks CM, Roth J. Circulating proinsulin-like component in man: increased proportion in hypoinsulinemic states. Diabetologia 1974;10:469-74.
    • (1974) Diabetologia , vol.10 , pp. 469-474
    • Gordon, P.1    Hendricks, C.M.2    Roth, J.3
  • 12
    • 0345121774 scopus 로고
    • Highly specific insulin assay reveals uniform insulin deficiency in non-insulin-dependent diabetics
    • Temple RC, Carrington CA, Luzio SD, Owens DR, Schneider AE, Sobey WJ, et al. Highly specific insulin assay reveals uniform insulin deficiency in non-insulin-dependent diabetics. Lancet 1989;i:1648-9.
    • (1989) Lancet , vol.1 , pp. 1648-1649
    • Temple, R.C.1    Carrington, C.A.2    Luzio, S.D.3    Owens, D.R.4    Schneider, A.E.5    Sobey, W.J.6
  • 14
    • 0030662718 scopus 로고    scopus 로고
    • Release of incompletely processed proinsulin is the cause of the disproportionate proinsulinemia of type 2 diabetes
    • Kahn SE, Halban PA. Release of incompletely processed proinsulin is the cause of the disproportionate proinsulinemia of type 2 diabetes. Diabetes 1997;46:1725-32.
    • (1997) Diabetes , vol.46 , pp. 1725-1732
    • Kahn, S.E.1    Halban, P.A.2
  • 15
    • 0031791047 scopus 로고    scopus 로고
    • Disproportionately elevated proinsulin levels reflect the degree of impaired β-cell secretory capacity in patients with non-insulin-dependent diabetes mellitus
    • Röder ME, Porte D, Schwartz RS, Kahn SE. Disproportionately elevated proinsulin levels reflect the degree of impaired β-cell secretory capacity in patients with non-insulin-dependent diabetes mellitus. J Clin Endocrinol Metab 1998;83:604-8.
    • (1998) J Clin Endocrinol Metab , vol.83 , pp. 604-608
    • Röder, M.E.1    Porte, D.2    Schwartz, R.S.3    Kahn, S.E.4
  • 16
    • 18844465935 scopus 로고    scopus 로고
    • Fasting intact proinsulin is a highly specific predictor of insulin resistance in type 2 diabetes
    • Pfutzner A, Kunt T, Hohberg C, Mondok A, Pahler S, Konrad T, et al. Fasting intact proinsulin is a highly specific predictor of insulin resistance in type 2 diabetes. Diabetes Care 2004;27:682-7.
    • (2004) Diabetes Care , vol.27 , pp. 682-687
    • Pfutzner, A.1    Kunt, T.2    Hohberg, C.3    Mondok, A.4    Pahler, S.5    Konrad, T.6
  • 17
    • 0027251602 scopus 로고
    • Insulin deficiency and increased plasma concentration of intact and 32/33 split proinsulin in subjects with impaired glucose tolerance
    • Davies MJ, Rayman G, Gray IP, Day JL, Hales CN. Insulin deficiency and increased plasma concentration of intact and 32/33 split proinsulin in subjects with impaired glucose tolerance. Diabet Med 1993;10:313-20.
    • (1993) Diabet Med , vol.10 , pp. 313-320
    • Davies, M.J.1    Rayman, G.2    Gray, I.P.3    Day, J.L.4    Hales, C.N.5
  • 18
    • 0030849251 scopus 로고    scopus 로고
    • Total immunoreactive proinsulin, immunoreactive insulin and specific insulin in relation to conversion to NIDDM: The Mexico City Diabetes Study
    • Haffner SM, Gonzales C, Mykkanen L, Stern M. Total immunoreactive proinsulin, immunoreactive insulin and specific insulin in relation to conversion to NIDDM: the Mexico City Diabetes Study. Diabetologia 1997;40:830-7.
    • (1997) Diabetologia , vol.40 , pp. 830-837
    • Haffner, S.M.1    Gonzales, C.2    Mykkanen, L.3    Stern, M.4
  • 19
    • 0030045866 scopus 로고    scopus 로고
    • Fasting proinsulin and 2-hour post-load glucose concentrations predict the conversion to NIDDM in subjects with impaired glucose tolerance: The Hoorn Study
    • Nijpels G, Popp-Snijders C, Kostense PJ, Bouter LM, Heine RJ. Fasting proinsulin and 2-hour post-load glucose concentrations predict the conversion to NIDDM in subjects with impaired glucose tolerance: the Hoorn Study. Diabetologia 1996;39:113-8.
    • (1996) Diabetologia , vol.39 , pp. 113-118
    • Nijpels, G.1    Popp-Snijders, C.2    Kostense, P.J.3    Bouter, L.M.4    Heine, R.J.5
  • 20
    • 0032949675 scopus 로고    scopus 로고
    • Fasting proinsulin concentrations predict the development of type 2 diabetes
    • Wareham NJ, Byrne CD, Williams R, Day NE, Hales CN. Fasting proinsulin concentrations predict the development of type 2 diabetes. Diabetes Care 1999;22:262-70.
    • (1999) Diabetes Care , vol.22 , pp. 262-270
    • Wareham, N.J.1    Byrne, C.D.2    Williams, R.3    Day, N.E.4    Hales, C.N.5
  • 21
    • 2542475544 scopus 로고    scopus 로고
    • Insulin resistance, impaired early insulin response, and insulin propeptides as predictors of the development of type 2 diabetes: A population-based, 7-year follow-up study in 70-year-old men
    • Zethelius B, Hales CN, Lithell H, Berne C. Insulin resistance, impaired early insulin response, and insulin propeptides as predictors of the development of type 2 diabetes: a population-based, 7-year follow-up study in 70-year-old men. Diabetes Care 2004;27:1433-8.
    • (2004) Diabetes Care , vol.27 , pp. 1433-1438
    • Zethelius, B.1    Hales, C.N.2    Lithell, H.3    Berne, C.4
  • 22
    • 0023177060 scopus 로고
    • Prolonged incubation in the two-colour immunofluorescence test increases the prevalence and titres of islet cell antibodies in type 1 (insulin-dependent) diabetes mellitus
    • Landin-Olsson M, Sundkvist G, Lernmark Å. Prolonged incubation in the two-colour immunofluorescence test increases the prevalence and titres of islet cell antibodies in type 1 (insulin-dependent) diabetes mellitus. Diabetologia 1987;30:327-32.
    • (1987) Diabetologia , vol.30 , pp. 327-332
    • Landin-Olsson, M.1    Sundkvist, G.2    Lernmark, Å.3
  • 23
    • 0030965672 scopus 로고    scopus 로고
    • 125I assays compared with [35S]GAD 65-ligand binding assay
    • 125I assays compared with [35S]GAD 65-ligand binding assay. Clin Chem 1997;43:779-85.
    • (1997) Clin Chem , vol.43 , pp. 779-785
    • Borg, H.1    Fernlund, P.2    Sundkvist, G.3
  • 24
    • 0031438330 scopus 로고    scopus 로고
    • Protein tyosine phosphatase-like protein IA2-antibodies plus glutamic acid decarboxylase 65 antibodies (GADA) indicates autoimmunity as frequently as islet cell antibodies assay in children with recently diagnosed diabetes mellitus
    • Borg H, Fernlund P, Sundkvist G. Protein tyosine phosphatase-like protein IA2-antibodies plus glutamic acid decarboxylase 65 antibodies (GADA) indicates autoimmunity as frequently as islet cell antibodies assay in children with recently diagnosed diabetes mellitus. Clin Chem 1997;43:2358-63.
    • (1997) Clin Chem , vol.43 , pp. 2358-2363
    • Borg, H.1    Fernlund, P.2    Sundkvist, G.3
  • 25
    • 0027436630 scopus 로고
    • Highly sensitive enzyme immunoassay of proinsulin immunoreactivity with use of two monoclonal antibodies
    • Kjems LL, Röder ME, Dinesen B, Hartling SG, Jörgensen PN, Binder C. Highly sensitive enzyme immunoassay of proinsulin immunoreactivity with use of two monoclonal antibodies. Clin Chem 1993;39:2146-50.
    • (1993) Clin Chem , vol.39 , pp. 2146-2150
    • Kjems, L.L.1    Röder, M.E.2    Dinesen, B.3    Hartling, S.G.4    Jörgensen, P.N.5    Binder, C.6
  • 26
    • 0024340494 scopus 로고
    • Sensitive and specific two-site immunoradiometric assays for human insulin, proinsulin, 65-66 split and 32-33 split proinsulins
    • Sobey WJ, Beer SF, Carrington CA, Clark PM, Frank BH, Gray IP, et al. Sensitive and specific two-site immunoradiometric assays for human insulin, proinsulin, 65-66 split and 32-33 split proinsulins. Biochem J 1989;260:535-41.
    • (1989) Biochem J , vol.260 , pp. 535-541
    • Sobey, W.J.1    Beer, S.F.2    Carrington, C.A.3    Clark, P.M.4    Frank, B.H.5    Gray, I.P.6
  • 27
    • 0029897364 scopus 로고    scopus 로고
    • Proinsulin secretion during the first 3 years after diagnosis in diabetic patients with or without islet cell antibodies
    • Gottsäter A, Owens DR, Luzio S, Sundkvist G. Proinsulin secretion during the first 3 years after diagnosis in diabetic patients with or without islet cell antibodies. Diabetes Care 1996;19:659-62.
    • (1996) Diabetes Care , vol.19 , pp. 659-662
    • Gottsäter, A.1    Owens, D.R.2    Luzio, S.3    Sundkvist, G.4
  • 28
    • 0026043872 scopus 로고
    • Prolonged maximal stimulation of insulin secretion in healthy subjects does not provoke preferential release of proinsulin
    • Nauck MA, Siegel EG, Creutzfeldt W. Prolonged maximal stimulation of insulin secretion in healthy subjects does not provoke preferential release of proinsulin. Pancreas 1991;6:645-52.
    • (1991) Pancreas , vol.6 , pp. 645-652
    • Nauck, M.A.1    Siegel, E.G.2    Creutzfeldt, W.3
  • 29
    • 0030030164 scopus 로고    scopus 로고
    • Proinsulin, C-peptide and insulin in normal subjects during eight hours hyperglycemic clamp
    • Hartling SG, Röder ME, Dinesen B, Binder C. Proinsulin, C-peptide and insulin in normal subjects during eight hours hyperglycemic clamp. Eur J Endocrinol 1996;134:197-200.
    • (1996) Eur J Endocrinol , vol.134 , pp. 197-200
    • Hartling, S.G.1    Röder, M.E.2    Dinesen, B.3    Binder, C.4
  • 30
    • 0035073980 scopus 로고    scopus 로고
    • Combinations of beta-cell specific autoantibodies at diagnosis of diabetes in young adults reflect different courses of beta-cell damage
    • Törn C, Landin-Olsson M, Lernmark Å, Scherstén B, Östman J, Arnqvist HJ, et al. Combinations of beta-cell specific autoantibodies at diagnosis of diabetes in young adults reflect different courses of beta-cell damage. Autoimmunity 2001;33:115-20.
    • (2001) Autoimmunity , vol.33 , pp. 115-120
    • Törn, C.1    Landin-Olsson, M.2    Lernmark, Å.3    Scherstén, B.4    Östman, J.5    Arnqvist, H.J.6
  • 31
    • 0024435846 scopus 로고
    • Elevated proinsulin in healthy siblings of IDDM patients independent of HLA identity
    • Hartling SG, Lindgren F, Dahlqvist G, Persson B, Binder C. Elevated proinsulin in healthy siblings of IDDM patients independent of HLA identity. Diabetes 1989;38:1271-4.
    • (1989) Diabetes , vol.38 , pp. 1271-1274
    • Hartling, S.G.1    Lindgren, F.2    Dahlqvist, G.3    Persson, B.4    Binder, C.5
  • 32
    • 0025850463 scopus 로고
    • Glucose-induced insulin response is reduced and proinsulin response increased in healthy siblings of type 1 diabetic patients
    • Lindgren FA, Hartling SG, Dahlqvist GG, Binder C, Efendic S, Persson BE. Glucose-induced insulin response is reduced and proinsulin response increased in healthy siblings of type 1 diabetic patients. Diabet Med 1991;8:638-43.
    • (1991) Diabet Med , vol.8 , pp. 638-643
    • Lindgren, F.A.1    Hartling, S.G.2    Dahlqvist, G.G.3    Binder, C.4    Efendic, S.5    Persson, B.E.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.