High frequency of persisting or increasing islet-specific autoantibody levels after diagnosis of type I diabetes presenting before 40 years of age

Diabetes Care

Volumn 23, Issue 6, 2000, Pages 838-844

  Decochez, Katelijn ^c   Tits, Jozef ^b   Coolens, Jean Luc ^c   Van Gaal, Luc ^d   Krzentowski, Georges ^e   Winnock, Frederic ^c   Anckaert, Ellen ^a   Weets, Ilse ^c   Pipeleers, Daniel G ^c   Gorus, Frans K ^f  

^a UNIVERSITY HOSPITAL BRUSSELS   (Belgium)

^b Department of Endocrinology   (Belgium)

^c Salvator Zickenhuis ^*

^d ANTWERP UNIVERSITY HOSPITAL   (Belgium)

^e Hopital Civil de Jumet   (Belgium)

^f DIABETES RESEARCH CENTER   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; INSULIN;

ADOLESCENT; ADULT; ANTIBODY DETECTION; ANTIBODY SPECIFICITY; ANTIBODY TITER; ARTICLE; AUTOIMMUNE DISEASE; CHILD; FEMALE; HUMAN; IMMUNOFLUORESCENCE; INFANT; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN TREATMENT; MAJOR CLINICAL STUDY; MALE;

EID: 0343191485     PISSN: 01495992     EISSN: None     Source Type: Journal    
DOI: 10.2337/diacare.23.6.838     Document Type: Article

References (34)

1. Palmer J-P: Predicting IDDM. Diabetes Rev 1:104-114, 1943
2. Bingley PJ, Bonifacio E, Gale EAM: Can we really predict IDDM? Diabetes 42:213-220, 1993
3. Bach J-F: Insulin-dependent diabetes mellitus as an autoimmune disease. Endocr Rev 15:516-542, 1994
4. Christie MR: Islet cell autoantigens in type I diabetes. Eur J Clim Invest 26:827-838, 1996
5. Slover RH, Eisenbarth GS: Prevention of type I diabetes and recurrent β-cell destruction of transplanted islets. Endocr Rev 18:241-258, 1997
6. The Expert Committee on the Diagnosis and Classification of Diabetes Mellitus: Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Diabetes Care 20:1183-1197, 1997
7. Gorus FK, the Belgian Diabetes Registry: Diabetes registries and early biological markers of insulin-dependent diabetes mellitus. Diabetes Metab Rev 13:247-274, 1997
8. Eizirik DL, Sandler S, Palmer JP: Repair of pancreatic β-cells: a relevant phenomenon in early IDDM? Diabetss 42:1 383-1 391, 1993
9. Myers MA, Rabin DU, Rowley MJ: Pancreatic islet cell cytoplasmic antibody in diabetes is represented by antibodies to islet cell antigen 512 and glutamic acid decarboxylase. Diabetes 44:1290-1295, 1995
10. Decochez K, Keymeulen B, Somers G, Dorchy H, De Leeuw I, Mathieu C, Rottiers R, Winnock F, ver Elst K, Weets I, Pipeleers D, Gorus F, the Belgian Diabetes Registry: Use of islet cell antibody assay to identify type I diabetic patients with rapid decrease in C-peptide levels after clinical onset (Abstract). Diabetologia 42:A62, 1999
11. Kolb H, Dannehl K, Gruneklee D, Zielasek J, Bertrams J, Hübinger A, Gries FA: Prospective analysis of islet cell antibodies in children with type I (insulin-dependent) diabetes. Diabetologia 31:189-194, 1988
12. Yokota I, Matsuda J, Naito E, Ito M, Shima K, Kuroda Y: Comparison of GAD and ICA512/ IA-2 antibodies at and alter the onset of IDDM. Diabetes Care 21:49-52, 1998
13. Savola K, Sabbah E, Kulmala P, Vähäsalo P, Ilonen J, Knip M: Autoantibodies associated with type I diabetes mellitus persist after diagnosis in children. Diabetologia 41: 1293-1297, 1998
14. Pipeleers DG, Ling Z: Pancreatic β-cells in insulin-dependent diabetes. Diabetes Metab Rev 8:209-227, 1992
15. Krolewski AS, Warram JH, Randl I, Kahn CR: Epidemiologic approach to the etiology of type I diabetes mellitus and its complications. N Engl J. Med 317:1390-1398, 1987
16. Caillat-Zucman S, Garchon HY, Timsit J, Assan R, Boitard C, Djiłali-Saiah I, Bougneres P, Bach J-F: Age-dependent heterogeneity of type I insulin-dependent diabetes mellitus J Clin Invest 90:2241-2251, 1992
17. Karjalainen J, Salmela P, Ilonen J, Surcel HM, Knip M: A comparison of childhood and adult type I diabetes mellitus. N Engl J Med 320:881-886, 1989
18. Vandewalle CI., Decraene T, Schuit FC, De Leeuw IH, Pipeleers DG, Gorus FK, the Belgian Diabetes Registry: Insulin autoantibodies and high titre islet cell antibodies are preferentially associated with the HLA DQ A 1 *0301 - DQ B1 *0302 haplotype at onset of type I (insulin-dependent) diabetes mellitus before age 10 years, but not at onset. between age 10 and 40 years. Diabetologia 36:1155-1162, 1993
19. National Diabetes Data Group: Classification and diagnosis of diabetes mellitus and other categories of glucose intolerance. Diabetes 28:1039-1057, 1979
20. 63-autoantibodies in new onset IDDM patients and help predict impending diabetes in their siblings. Diabetologia 40:95-99, 1997
21. Vandewalle CL, Falorni A, Lernmark Å, Goubert P, Dorchy H, Coucke W, Semakula C, Van der Auwera B, Kaufman L, Schuit FC, Pipeleers DG, Gorus FK, the Belgian Diabetes Registry: Associations of GAD65-and IA-2-autoantibodies with genetic risk markers in new-onset IDDM patients and their siblings, Diabetes Care 20:1547-1552, 1997
22. Verge CF, Stenger D, Bonifacio E, Colman P, Pilcher C, Bingley P, Eisenbarth GS, participating laboratories: Combined use of autoantibodies (IA2ab, GADab, IAA, ICA): combinatorial islet autoantibody workshop. Diabetes 47:1857-1866, 1998
23. Marshall WJ: Biochemical tests in clinical medicine. In Clinical Chemistry. 3rd ed. London, Mosby, 1995
24. Keymeulen B, Ling Z, Gorus FK, Delvaux G, Bouwens L, Grupping A, Hendrieckx C, Pipeleers-Marichal M, Van Schravendijk C, Salmela K, Pipeleers DG: Implantation of standardized beta-cell grafts in a liver segment of IDDM patients: graft and recipient characteristics in two cases of insulin-independence under maintenance immunosuppression for prior kidney graft. Diabetologia 41:452-460, 1998
25. Van der Auwera B, Schuit F, Lyaruu I, Falorni A, Svanholm S, Vandewalle CL, Gorus FK, the Belgian Diabetes Registry: Genetic susceptibility for insulin-dependent diabetes mellitus in Caucasians revisited: the importance of diabetes registries in disclosing interactions between HLA-DQ-and insulin-gene linked risk. J Clin Endocrinol Metab 80:2567-2573, 1995
26. 65-antibodies after clinical diagnosis of IDDM in young children. Diabetes Care 20:642-644, 1997
27. Cucca F, Goy JV, Kawaguchi Y, Esposito L. Merriman ME, Wilson AJ, Cordell HJ, Bain SC, Todd JA: A male-female bias in type I diabetes and linkage to chromosome Xp in MHC HLA-DR3-positive patients. Nat Genet 19:301-302, 1998
28. Ludvigsson J, Samuelsson U, Beauforts C, Deschamps I, Dorchy H, Drash A, François R, Herx G, New M, Schober E: HLA-DR3 is associated with a more slowly progressive form of type I (insulin-dependent) diabetes. Diabetologia 29:207-210, 1986
29. Genovese S, Bonfanti R, Bazzigaluppi E, Lampasona V, Benazzi E, Bosi E, Chiumello G, Bonifacio E: Association of IA-2 autoantibodies with HLA DR4 phenotypes in IDDM. Diabetologia, 39:1223-1226, 1996
30. Landin-Olsson M, Arnqvist HJ, Blohmé G, Littorin B, Lithner F, Nystrom L, Schersten B, Sundkvist G, Wibell L, Östman J, Lernmark Å: Appearance of islet cell autoantibodies after clinical diagnosis of diabetes mellitus. Autoimmunity 29:57-63, 1999
31. Weets I, Siraux V, Daubresse J-C, Krzentowski G, Féry F, Van der Auwera BJ, Pipeleers DG, Gorus FK, the Belgian Diabetes Registry: Clinical and biological differences between autoantibody-positive and -negative adulthood-onset diabetes. Diabetologia 41 (Suppl. 1):A92, 1998
32. Östman J, Lernmark A, Landin-Olsson M, Sundkvist G, Palmer J, Arnqvist H, Blohmé G, Lithner F, Littorin B, Nyström L. Schersten B, Wibell L: Autoimmune (type 1) diabetes in young adults in Sweden. Horm Metab Res 28:348-350, 1996
33. Pozzilli P, Visalli N, Buzzetti R, Cavallo MG, Marietti G, Hawa M, Leslie RDG, the IMDIAB-Study Group: Metabolic and immune parameters at clinical onset of insulin-dependent diabetes: a population-based study. Metabolism 47:1205-1210, 1998
34. 65 and IA-2 marks the early phases of autoimmune in type I diabetes. J Clin Invest 97: 2772-2783, 1996