Total immunoreactive proinsulin, immunoreactive insulin and specific insulin in relation to conversion to NIDDM: The Mexico City Diabetes Study

Diabetologia

Volumn 40, Issue 7, 1997, Pages 830-837

  Haffner, S M ^a   Gonzalez, C ^b   Mykkanen L ^a   Stern, M ^a  

^a UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^b INSTITUTO MEXICANO DEL SEGURO SOCIAL   (Mexico)

Author keywords

Insulin; Insulin secretion; Noninsulin dependent diabetes mellitus; Proinsulin

Indexed keywords

GLUCOSE; INSULIN; PROINSULIN;

ADULT; ARTICLE; BODY FAT; FEMALE; GLUCOSE TOLERANCE; HUMAN; IMPAIRED GLUCOSE TOLERANCE; INSULIN RELEASE; INSULIN RESISTANCE; MAJOR CLINICAL STUDY; MALE; MEXICO; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; ORAL GLUCOSE TOLERANCE TEST; PRIORITY JOURNAL;

ADULT; BODY MASS INDEX; CONFIDENCE INTERVALS; DIABETES MELLITUS, TYPE 2; FEMALE; FOLLOW-UP STUDIES; GLUCOSE INTOLERANCE; HUMANS; INSULIN; LONGITUDINAL STUDIES; MALE; MEXICO; MIDDLE AGED; ODDS RATIO; POVERTY; PROINSULIN; RADIOIMMUNOASSAY; RISK FACTORS; TIME FACTORS; URBAN POPULATION;

EID: 0030849251     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s001250050756     Document Type: Article

References (46)

1. DeFronzo RA (1988) The triumvirate: β-cell, muscle, liver: collusion responsible for NIDDM. Diabetes 37: 667-687
2. Reaven GM, Bernstein R, Davis B, Olefsky JM (1976) Non-ketotic diabetes mellitus: insulin deficiency or insulin resistance. Am J Med 60: 80-88
3. Porte D (1991) β-cells in type II diabetes mellitus. Diabetes 40: 166-180
4. Sicree RA, Zimmett PZ, King HOM, Coventry JS (1987) Plasma insulin response among Nauruans: prediction of deterioration in glucose tolerance over 6 years. Diabetes 36: 179-186
5. Haffner SM, Stern MP, Mitchell BD, Hazuda HP, Patterson JK (1990) Incidence of type II diabetes in Mexican Americans predicted by fasting insulin and glucose levels, obesity and body fat distribution. Diabetes 39: 283-288
6. Bergstrom RW, Newell-Morris LL, Leonetti DL, Shuman WP, Wahl PW, Fujimoto WY (1990) Association of elevated fasting C-peptide level and increased intra-abdominal fat distribution with development of NIDDM in Japanese American men. Diabetes 39: 104-111
7. Charles MA, Fontbonne A, Thibult N, Warnet JM, Rosselin GE, Eschwege R (1991) Risk factors for NIDDM in white population: Paris prospective study. Diabetes 40: 796-799
8. Mykkänen L, Kuusisto J, Pyörälä K, Laakso M (1993) Cardiovascular disease risk factors as predictors of type 2 (non-insulin-dependent) diabetes mellitus in elderly subjects. Diabetologia 36: 553-559
9. Saad MF, Knowler WC, Pettitt DJ, Nelson RG, Mott DM, Bennett PH (1988) The natural history of impaired glucose tolerance in the Pima Indians. N Engl J Med 319: 1500-1506
10. Lundgren H, Bengtsson C, Blohme G, Lapidus L, Waldenström J (1990) Fasting serum insulin concentration and early insulin response as risk determinants for developing diabetes. Diabet Med 7: 407-413
11. Haffner SM, Miettinen H, Gaskill SP, Stern MP (1995) Decreased insulin secretion and increased insulin resistance are independently related to the 7-year risk of non-insulin dependent diabetes mellitus. Diabetes 44: 1386-1391
12. Hollenbeck CB, Chen N, Chen YDI, Reaven GM (1984) Relationship between the plasma insulin response to oral glucose and insulin stimulated glucose utilization in normal subjects. Diabetes 33: 460-463
13. Saad MF, Anderson RL, Laws A, et al. for the Insulin Resistance Atherosclerosis Study (1994) Comparison between the minimal model and the glucose clamp in the assessment of insulin sensitivity across the spectrum of glucose tolerance. Diabetes 43: 1114-1121
14. Laakso M (1993) How good a marker is insulin level for insulin resistance? Am J Epidemiol 137: 959-965
15. Lillioja S, Mott DM, Spraul M et al. (1993) Insulin resistance and insulin secretory dysfunction as precursors of non-insulin-dependent diabetes mellitus: prospective studies of Pima Indians. N Engl J Med 329:1988-1992
16. Warram JH, Martin BC, Krolewski AS, Soeldner JS, Kahn CR (1990) Slow glucose removal rate and hyperinsulinemia precede the development of type II diabetes in the off-spring of diabetic parents. Ann Intern Med 113: 903-915
17. Efendic S, Luft R, Wajngot A (1984) Aspects of the pathogenesis of type 2 diabetes. Endocr Rev 5: 395-410
18. Kosaka K, Hagura R, Kuzuya T (1977) Insulin responses in equivocal and definite diabetes with special reference to subjects who had mild glucose intolerance but later developed definite diabetes. Diabetes 26: 944-952
19. Kadowaki T, Miyake Y, Hagura R et al. (1984) Risk factors for worsening to diabetes in subjects with impaired glucose tolerance. Diabetologia 26: 44-49
20. Watanabe RM, Laws A, Rewers M, Bergman RN for the IRAS investigators (1995) Impaired glucose tolerant subjects exhibit a β-cell defect despite normal fasting glycemia. Diabetes 44[Suppl 1]:5A (Abstract)
21. Mitrakou A, Kelley D, Mokan M et al. (1992) Role of reduced suppression of glucose production and diminished early insulin release in impaired glucose tolerance. N Engl J Med 326: 22-29
22. Robbins DC, Andersen L, Bowsher R et al. (1996) Task Force Report. Report of the American Diabetes Associations Task Force on standardization of the insulin assay. Diabetes 45: 242-256
23. Haffner SM, Bowsher RR, Mykkänen L et al. (1994) Proinsulin and specific insulin concentration in high and low risk populations for NIDDM. Diabetes 43: 1490-1493
24. Temple RC, Carrington CA, Luzio SD et al. (1989) Insulin deficiency in non-insulin-dependent diabetes. Lancet 1:293-295
25. Reaven GM, Chen YDI, Hollenbeck CB, Shen WHH, Ostrega D, Polonsky KS (1993) Plasma insulin, C-peptide and proinsulin concentrations in obese and non-obese individuals with varying degrees of glucose tolerance. J Clin Endocrinol Metab 76: 44-48
26. Yoshioka N, Kuzuya T, Matsuda A, Taniguchi M, Iwamoto Y (1988) Serum proinsulin levels at fasting and after oral glucose load in patients with type 2 (non-insulin-dependent) diabetes mellitus. Diabetologia 31: 355-360
27. Saad MF, Kahn SE, Nelson RG et al. (1990) Disproportionately elevated proinsulin in Pima Indians with non-insulin-dependent diabetes mellitus. J Clin Endocrinol Metab 70: 1247-1253
28. Davies M, Metcalfe J, Gray IP, Day JL, Hales CN (1993) Insulin deficiency and increased plasma concentrations of intact and 32/33 split proinsulin in subjects with impaired glucose tolerance. Diabet Med 10: 313-320
29. Kahn SE, Leonetti DL, Prigeon RL, Boyko EJ, Bergstrom RW, Fujimoto WY (1995) Proinsulin as a marker for the development of NIDDM in Japanese American men. Diabetes 44: 173-179
30. Mykkänen L, Haffner SM, Kuusisto J, Pyöräla, Hales CN, Laakso M (1995) Serum proinsulin levels are disproportionately increased in elderly prediabetic subjects. Diabetologia 38: 1176-1182
31. Nijpels G, Popp-Snijders C, Kostense PJ, Bouter LM, Heine RJ (1996) Fasting proinsulin and 2-h post glucose levels predict the conversion to NIDDM in subjects with impaired glucose tolerance: the Hoorn Study. Diabetologia 39: 113-118
32. Stern MP, Gonzalez C, Mitchell BD, Villalpando E, Haffner SM, Hazuda HP (1992) Genetic and environmental determinants of type II diabetes in Mexico City and San Antonio. Diabetes 41: 484-492
33. González C, Stern MP, Mitchell BD, Valdez R, Haffner SM, Pérez BA (1994) Clinical characteristics of type II diabetic subjects consuming high vs low carbohydrate diets in Mexico City and San Antonio, TX. Diabetes Care 17: 397-404
34. Haffner SM, Gonzalez C, Miettinen H, Kennedy E, Stern MP (1996) A prospective analysis of the HOMA model. Diabetes Care 19: 1138-1141
35. Haffner SM, Stern MP, Hazuda HP, Pugh JA, Patterson JK, Malina R (1986) Upper body and centralized adiposity in Mexican Americans and non-Hispanic whites: relationship to body mass index and other behavioral and demographic variables. Int J Obes 10: 493-502
36. Haffner SM, Stern MP, Hazuda HP, Pugh J, Patterson J (1986) Hyperinsulinemia in a population at high risk for non-insulin dependent diabetes mellitus. N Engl J Med 315: 220-224
37. Haffner SM, Stern MP, Miettinen H, Gingerich R, Bowsher RR (1995) Higher proinsulin and specific insulin are both associated with a parental history of diabetes in non-diabetic Mexican American subjects. Diabetes 44: 1156-1160
38. Bowsher RR, Wolny JD, Frank BH (1992) A rapid and sensitive radioimmunoassay for the measurement of proinsulin in human serum. Diabetes 41: 1084-1090
39. World Health Organization Study Group on Diabetes Mellitus (1985) Diabetes Mellitus: Report of a WHO Study Group. Geneva, World Health Organization, pp.94-98 (Tech. Rep. Ser. No.727)
40. Berne C, Lithell H, Clark PMS, Hales CN (1994) Split proinsulin is an early marker of non-insulin dependent diabetes mellitus. Diabetologia 37[Suppl 1]:A57 (Abstract)
41. Saad MF, Knowler WC, Pettitt DJ et al. (1991) A two-step model for development of non-insulin-dependent diabetes. Am J Med 90: 229-235
42. Porte D Jr, Kahn SE (1989) Hyperproinsulinemia and amyloid in NIDDM: clues to etiology of islet β-cell dysfunction? Diabetes 38: 1333-1336
43. Halban PA (1991) Structural domains and molecular lifestyles of insulin and its precursors in the pancreatic beta cell. Diabetologia 34: 767-778
44. Rhodes CJ, Alarcón C (1994) What β-cell defect could lead to hyperproinsulinemia in NIDDM? Diabetes 43: 511-517
45. Wasada T, Kuroki H, Arii H et al. (1994) Physiological increase in plasma insulin concentration suppresses proinsulin secretion in normal controls but not in subjects with glucose intolerance. Endocrine J 41: 183-188
46. Mykkänen L, Haffner SM, Hales CN, Rönnemaa T, Laakso M (1997) The relation of proinsulin, insulin and proinsulin-to-insulin ratio to insulin sensitivity and acute insulin response in normoglycemic subjects. Diabetes (in press)