Biosynthesis of the neurosteroid 3α-hydroxy-4-pregnen-20-one (3αHP), a specific inhibitor of FSH release

Endocrinology

Volumn 142, Issue 11, 2001, Pages 4617-4622

  Griffin, Lisa D ^a   Mellon, Synthia H ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3ALPHA DIHYDROPROGESTERONE; 3ALPHA HYDROXYSTEROID DEHYDROGENASE; FOLLITROPIN; INDOMETACIN; ISOENZYME; NEUROSTEROID; PROGESTERONE; RECOMBINANT ENZYME;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; FEMALE; FOLLITROPIN RELEASE; GONADOTROPIN SECRETING CELL; HORMONAL REGULATION; HORMONE INHIBITION; IN VITRO STUDY; NONHUMAN; PRIORITY JOURNAL; RAT; STEROIDOGENESIS; TISSUE SPECIFICITY; TRANQUILIZING ACTIVITY;

EID: 0034751590     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/endo.142.11.8477     Document Type: Article

References (24)

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2. Synthesis, metabolism and levels of the neuroactive steroid, 3α-hydroxy-4-pregnen-20-one (3αHP), in rat pituitaries
3. Progesterone-transforming enzyme activity in the hypothalamus of the male rat
4. Synthesis of the allylic regulatory steroid, 3α-hydroxy-4-pregnen-20-one, by rat granulosa cells and its regulation by gonadotropins
5. Selective suppression of follicle-stimulating hormone secretion in anterior pituitary cells by the gonadal steroid 3α-hydroxy-4-pregnen-20-one
6. Suppression in gonadotropes of gonadotropin-releasing hormone-stimulated follicle-stimulating hormone release by the gonadal- and neurosteroid 3α-hydroxy-4-pregnen-20-one involves cytosolic calcium
7. Suppression of follicle-stimulating hormone by the gonadal- and neurosteroid 3α-hydroxy-4-pregnen-20-one involves actions at the level of the gonadotrope membrane/calcium channel
8. Characterization of steroid interactions with gamma-aminobutyric acid receptor-gated chloride ion channels: Evidence for multiple steroid recognition sites
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13. cDNA cloning and expression of the human hepatic bile acid-binding protein. A member of the monomeric reductase gene family
14. The 4-pregnene and 5α-pregnane progesterone metabolites formed in nontumorous and tumorous breast tissue have opposite effects on breast cell proliferation and adhesion
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