DNA as a marker of cell death in systemic lupus erythematosus

Rheumatic Disease Clinics of North America

Volumn 30, Issue 3, 2004, Pages 575-587

  Pisetsky, David S ^a,b  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b DURHAM VA MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; CYTOKINE; DEXAMETHASONE; DNA; DOUBLE STRANDED DNA; FAS LIGAND; INTERFERON; LIPOSOME; OLIGONUCLEOTIDE; PLASMA PROTEIN;

ANTIGEN ANTIBODY COMPLEX; APOPTOSIS; AUTOIMMUNE DISEASE; BLOOD LEVEL; CELL DAMAGE; CELL DEATH; CELL NUCLEUS; CELL SURFACE; DNA CLEAVAGE; DNA DEGRADATION; DNA DETERMINATION; DNA ISOLATION; GENE EXPRESSION; GLOMERULONEPHRITIS; HUMAN; IMMUNOASSAY; MACROPHAGE; NONHUMAN; NUCLEOSOME; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; REVIEW; STATISTICAL SIGNIFICANCE; SYSTEMIC LUPUS ERYTHEMATOSUS; Y CHROMOSOME;

ANIMALS; ANTIBODIES, ANTINUCLEAR; APOPTOSIS; BIOLOGICAL MARKERS; DISEASE MODELS, ANIMAL; DNA; HUMANS; LUPUS ERYTHEMATOSUS, SYSTEMIC;

EID: 3142730583     PISSN: 0889857X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.rdc.2004.04.009     Document Type: Review

References (55)

1. Kotzin B.L. Systemic lupus erythematosus. Cell. 85:1996;303-306
2. Pisetsky D.S. Anti-DNA antibodies in systemic lupus erythematosus. Rheum Dis Clin N Am. 18:1992;437-454
3. Mohan C., Datta S.K. Lupus: key pathogenic mechanisms and contributing factors. Clin Immunol Immunopathol. 77:1995;209-220
4. Amoura Z., Chabre H., Bach J.-F., Koutouzov S. Antinucleosome antibodies and systemic lupus erythematosus. Adv Nephrol. 26:1997;303-316
5. Vallin H., Perers A., Alm G.V., Ronnblom L. Anti-double-stranded DNA antibodies and immunostimulatory plasmid DNA in combination mimic the endogenous IFN-α inducer in systemic lupus erythematosus. J Immunol. 1163:1999;6306-6313
6. Bave U., Alm G.V., Ronnblom L. The combination of apoptotic U937 cells and lupus IgG is a potent IFN-α inducer. J Immunol. 165:2000;3519-3526
7. Leadbetter E.A., Rifkin I.R., Hohlbaum A.M., Beaudette B.C., Shlomchik M.J., Marshak-Rothstein A. Chromatin-IgG complexes activate B cells by dual engagement of IgM and toll-like receptors. Nature. 416:2002;603-607
8. Pisetsky D.S. Immune activation by bacterial DNA: a new genetic code. Immunity. 5:1996;303-310
9. Tokunaga T., Yamamoto H., Yamamoto S. How BCG led to the discovery of immunostimulatory DNA. Jpn J Infect Dis. 52:1999;1-11
10. Andrade F., Casciola-Rosen L., Rosen A. Apoptosis in systemic lupus erythematosus: antibodies in systemic lupus erythematosus. Rheum Dis Clin N Am. 26:2000;215-227
11. Majno G., Joris I. Apoptosis, oncosis, and necrosis: an overview of cell death. Am J Pathol. 146:1995;3-15
12. Leist M., Jaattela M. Four deaths and a funeral: from caspases to alternative mechanisms. Mol Cell Biol. 2:2001;1-10
13. Rovere P., Sabbadini M.G., Fazzini F., Bondanza A., Zimmermann V.S., Rugarli C., et al. Remnants of suicidal cells fostering systemic autoaggression. Arthritis Rheum. 43:2000;1663-1672
14. Voll R.E., Herrmann M., Roth E.A., Stach C., Kalden J.R. Immunosuppressive effects of apoptotic cells. Nature. 390:1997;350-351
15. Fadok V.A., Bratton D.L., Henson P.M. Phagocyte receptors for apoptotic cells: recognition, uptake, and consequences. J Clin Invest. 108:2001;957-962
16. Sauter B., Albert M.L., Francisco L., Larsson M., Somersan S., Bhardwaj N. Consequences of cell death: exposure to necrotic tumor cells, but not primary tissue cells or apoptotic cells, induces the maturation of immunostimulatory dendritic cells. J Exp Med. 191:2000;423-433
17. McDonald P.P., Fadok V.A., Bratton D., Henson P.M. Transcriptional and translational regulation of inflammatory mediator production by endogenous TGF-β in macrophages that have ingested apoptotic cells. J Immunol. 163:1999;6164-6172
18. Fadok V.A., Bratton D.L., Guthrie L., Henson P.M. Differential effects of apoptotic versus lysed cells on macrophage production of cytokines: role of proteases. J Immunol. 166:2001;6847-6854
19. Savill J. Recognition and phagocytosis of cells undergoing apoptosis. Br Med Bull. 53:1997;491-508
20. Ren Y., Savill J. Apoptosis: the importance of being eaten. Cell Death Differ. 5:1998;563-568
21. Fadok V.A., Bratton D.L., Henson P.M. Phagocyte receptors for apoptotic cells: recognition, uptake, and consequences. J Clin Invest. 108:2001;957-962
22. Henson P.M., Bratton D.L., Fadok V.A. The phosphatidylserine receptor: a crucial molecular switch? Mol Cell Biol. 2:2001;627-633
23. Gershov D., Kim S.J., Brot N., Elkson K.B. C-reactive protein binds to apoptotic cells, protects the cells from assembly of the terminal complement components, and sustains an antiinflammatory innate immune response: implications for systemic autoimmunity. J Exp Med. 192:2000;1353-1363
24. Gaipl U.S., Kuenkele S., Voll R.E., Beyer T.D., Kolowos K., Heyder P., et al. Complement binding is an early feature of necrotic and rather late event during apoptotic cell death. Cell Death Diff. 8:2001;327-334
25. Pickering M.C., Botto M., Taylor P.R., Lachmann P.J., Walport M.J. Systemic lupus erythematosus, complement deficiency, and apoptosis. Adv Immunol. 76:2001;227-325
26. Familian A., Zwart B., Huisman H.G., Rensink I., Roem D., Hordijk P.L., et al. Chromatin-independent binding of serum amyloid P component to apoptotic cells. J Immunol. 167:2001;647-654
27. Kim S.J., Gershov D., Ma X., Brot N., Elkon K.B. I-PLA2 activation during apoptosis promotes the exposure of membrane lysophosphatidylcholine leading to binding by natural immunoglobulin M antibodies and complement activation. J Exp Med. 196:2002;655-665
28. Mitchell D.A., Pickering M.C., Warren J., Fossati-Jimack L., Cortes-Hernandez J., Cook H.T., et al. C1q deficiency and autoimmunity: the effects of genetic background on disease expression. J Immunol. 168:2002;2538-2543
29. Lorenz H.-M., Herrmann M., Winkler T., Gaipl U., Kalden J.R. Role of apoptosis in autoimmunity. Apoptosis. 5:2000;443-449
30. Shapiro B., Chakrabarty M., Cohn E.M., Leon S.A. Determination of circulating DNA levels in patients with benign or malignant gastrointestinal disease. Cancer. 51:1983;2116-2120
31. Steinman C.R. Circulating DNA in systemic lupus erythematosus. Isolation and characterization. J Clin Invest. 73:1984;832-841
32. Stroun M., Anker P., Maurice P., Lyautey J., Lederrey C., Beljanski M. Neoplastic characteristics of the DNA found in the plasma of cancer patients. Oncology. 46:1989;318-322
33. Rumore P.M., Steinman C.R. Endogenous circulating DNA in systemic lupus erythematosus: occurrence as multimeric complexes bound to histone. J Clin Invest. 86:1990;69-74
34. Fournié G.J., Martres F., Pourrat J.P., Alary C., Rumeau M. Plasma DNA as cell death marker in elderly patients. Gerontology. 39:1993;215-221
35. Jahr S., Hentze H., Englisch S., Hardt D., Fackelmayer F.O., Hesch R.-D., et al. DNA fragments in the blood plasma of cancer patients: quantitations and evidence for their origin from apoptotic and necrotic cells. Cancer Res. 61:2001;1659-1665
36. Anker P., Lyautey J., Lederry C., Stroun M. Circulating nucleic acids in plasma or serum. Clin Chim Acta. 313:2001;143-146
37. Lo Y.M.D., Leung T.N., Tein M.S.C., Sargent I.L., Zhang J., Lau T.K., et al. Quantitative abnormalities of fetal DNA in maternal serum in preeclampsia. Clin Chem. 45:1999;184-188
38. Lui Y.Y.N., Lo Y.M.D. Circulating DNA in plasma and serum: biology, preanalytical issues and diagnostic applications. Clin Chem Lab Med. 40:2002;962-968
39. Lam N.Y.L., Rainer T.H., Chan L.Y.S., Joynt G.M., Lo Y.M.D. Time course of early and late changes in plasma DNA in trauma patients. Clin Chem. 49:2003;1286-1291
40. Baumann I., Kolowos W., Voll R.E., Manger B., Gaipl U., Neuhuber W.L., et al. Impaired uptake of apoptotic cells into tingible body macrophages in germinal centers of patients with systemic lupus erythematosus. Arthritis Rheum. 46:2002;191-201
41. Amoura Z., Piette J.C., Chabre H., Cacoub P., Papo T., Wechsler B., et al. Circulating plasma levels of nucleosomes in patients with systemic lupus erythematosus: correlation with serum antinucleosome antibody titers and absence of clear association with disease activity. Arthritis Rheum. 40:1997;2217-2225
42. Van Nieuwenhuijze A.E.M., van Lopik T., Smeenk R.J.T., Aarden L.A. Time between onset of apoptosis and release of nucleosomes from apoptotic cells: putative implications for systemic lupus erythematosus. Ann Rheum Dis. 62:2003;10-14
43. Licht R., van Bruggen M.C., Oppers-Walgreen B., Rijke T.P., Berden J.H. Plasma levels of nucleosomes and nucleosome-autoantibody complexes in murine lupus: effects of disease progression and lipopolysaccharide administration. Arthritis Rheum. 44:2001;1320-1330
44. Singer V.L., Jones L.J., Yue S.T., Haughland R.P. Characterization of PicoGreen reagent and development of a fluorescence-based solution assay for double-stranded DNA quantitation. Anal Biochem. 249:1997;228-238
45. Bjorkman L., Reich C.F., Pisetsky D.S. The use of fluorometric assays to assess the immune response to DNA in murine systemic lupus erythematosus. Scand J Immunol. 57:2003;525-533
46. Jiang N., Reich C.F., Monestier M., Pisetsky D.S. The expression of plasma nucleosomes in mice undergoing in vivo apoptosis. Clin Immunol. 106:2003;139-147
47. Jiang W., Pisetsky D.S. Enhancing immunogenicity by CpG DNA. Curr Opin Mol Ther. 5:2003;180-185
48. Sparwasser T., Miethke T., Lipford G., Borschert K., Hacker H., Heeg K., et al. Bacterial DNA causes septic shock. Nature. 386:1997;336-337
49. Myers L.P., Krieg A.M., Pruett S.B. Bacterial DNA does not increase serum corticosterone concentration or prevent increases induced by other stimuli. Int Immunopharmacol. 1:2001;1605-1614
50. Izui S., Lambert P.-H., Fournié G.J., Türler H., Miescher P.A. Features of systemic lupus erythematosus in mice injected with bacterial lipopolysaccharides: identification of circulating DNA and renal localization of DNA-anti-DNA complexes. J Exp Med. 145:1977;1115-1130
51. Izui S., Kobayakawa T., Zryd M.J., Louis J., Lambert P.-H. Mechanism for induction of anti-DNA antibodies by bacterial lipopolysaccharides in mice; II: correlation between anti-DNA induction and polyclonal antibody formation by various polyclonal B lymphocyte activators. J Immunol. 119:1977;2157-2162
52. Mor G., Singla M., Steinberg A.D., Hoffman S.L., Okuda K., Klinman D.M. Do DNA vaccines induce autoimmune disease? Hum Gene Ther. 8:1997;293-300
53. Jiang N., Reich C.F., Pisetsky D.S. Role of macrophages in the generation of circulating blood nucleosomes from dead and dying cells. Blood. 102:2003;2243-2250
54. VanRooijen N., Sanders A. Liposome mediated depletion of macrophages: mechanism of action, preparation of liposomes and applications. J Immunol Methods. 174:1994;83-93
55. Naito M., Nagai H., Kawano S., Umezu H., Zhu H., Moriyama H., et al. Liposome-encapsulated dichloromethylene diphosphonate induces macrophage apoptosis in vivo and in vitro. J Leuk Biol. 60:1996;337-344