Synthesis and biological evaluation of synthetic viridins derived from C(20)-heteroalkylation of the steroidal PI-3-kinase inhibitor wortmannin

Organic and Biomolecular Chemistry

Volumn 2, Issue 13, 2004, Pages 1911-1920

  Wipf, Peter ^a   Minion, Daniel J ^a   Halter, Robert J ^a   Berggren, Margareta I ^b   Ho, Caroline B ^c   Chiang, Gary G ^c   Kirkpatrick, Lynn ^d   Abraham, Robert ^c   Powis, Garth ^b  

^a UNIVERSITY OF PITTSBURGH   (United States)

^b UNIVERSITY OF ARIZONA   (United States)

^c BURNHAM INSTITUTE   (United States)

^d Biomira Inc   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ALKYLATION; CELLS; DERIVATIVES; ENZYMES; SYNTHESIS (CHEMICAL); TOXIC MATERIALS; TUMORS;

ANTIFUNGAL AGENTS; PHOSPHORYLATION; RESIDUES;

AROMATIC COMPOUNDS;

ANDROSTANE DERIVATIVE; BACTERIOCIN; PHOSPHATIDYLINOSITOL; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE INHIBITOR; VIRIDIN; WORTMANNIN;

ALKYLATION; ARTICLE; CELL PROLIFERATION; CHEMICAL STRUCTURE; CHEMISTRY; DRUG ANTAGONISM; DRUG EFFECT; ENZYME SPECIFICITY; HUMAN; IC 50; METABOLISM; SYNTHESIS; TUMOR CELL LINE;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ALKYLATION; ANDROSTADIENES; ANDROSTENES; BACTERIOCINS; CELL LINE, TUMOR; CELL PROLIFERATION; HUMANS; INHIBITORY CONCENTRATION 50; MOLECULAR STRUCTURE; PHOSPHATIDYLINOSITOLS; PROTEIN KINASE INHIBITORS; SUBSTRATE SPECIFICITY;

EID: 3142679468     PISSN: 14770520     EISSN: None     Source Type: Journal    
DOI: 10.1039/b405431h     Document Type: Article

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