The metabolic syndrome: A crossroad for genotype-phenotype associations in atherosclerosis

Current Atherosclerosis Reports

Volumn 6, Issue 3, 2004, Pages 186-196

  Corella, Dolores ^a   Ordovas, Jose M ^a  

^a TUFTS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FAT; HIGH DENSITY LIPOPROTEIN; INSULIN; LOW DENSITY LIPOPROTEIN;

ATHEROSCLEROSIS; BODY FAT; BODY WEIGHT; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; CHOLESTEROL BLOOD LEVEL; ENVIRONMENTAL FACTOR; GENETIC PREDISPOSITION; GENOTYPE PHENOTYPE CORRELATION; HEREDITY; HUMAN; HYPERTENSION; HYPERTRIGLYCERIDEMIA; INSULIN RESISTANCE; METABOLIC SYNDROME X; OBESITY; REVIEW;

EID: 3142623025     PISSN: 15233804     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11883-004-0031-8     Document Type: Review

References (67)

1. Olden K, Wilson S: Environmental health and genomics: visions and implications. Nat Rev Genet 2000, 1:149-153.
2. Reaven GM: Banting lecture 1988. Role of insulin resistance in human disease. Diabetes 1988, 37:1595-1607.
3. Groop L, Orho-Melander M: The dysmetabolic syndrome. J Intern Med 2001, 250:105-120.
4. Alberti KG, Zimmet PZ: Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation. Diabetes Med 1998, 15:539-553.
5. Executive Summary of The Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). JAMA 2001, 285:2486-2497.
6. Ford ES, Giles WH, Dietz WH: Prevalence of the metabolic syndrome among US adults: findings from the third National Health and Nutrition Examination Survey. JAMA 2002, 287:356-359.
7. Bonora E, Kiechl S, Willeit J, et al.: Metabolic syndrome: epidemiology and more extensive phenotypic description. Cross-sectional data from the Bruneck Study. Int J Obes Relat Metab Disord 2003, 27:1283-1289.
8. Meigs JB, Wilson PW, Nathan DM, et al.: Prevalence and characteristics of the metabolic syndrome in the San Antonio Heart and Framingham Offspring Studies. Diabetes 2003, 52:2160-2167.
9. Ninomiya JK, L'Italien G, Criqui MH, et al.: Association of the metabolic syndrome with history of myocardial infarction and stroke in the third national health and nutrition examination survey. Circulation 2004, 109:42-46.
10. Lakka HM, Laaksonen DE, Lakka TA, et al.: The metabolic syndrome and total and cardiovascular disease mortality in middle-aged men. JAMA 2002, 288:2709-2716.
11. Neel JV: Diabetes mellitus: a "thrifty" genotype rendered detrimental by "progress"? Am J Hum Genet 1962, 14:353-362.
12. Hales CN, Barker DJ: Type 2 (non-insulin-dependent) diabetes mellitus: the thrifty phenotype hypothesis. Diabetologia 1992, 35:595-601.
13. Wolf G: Adult type 2 diabetes induced by intrauterine growth retardation. Nutr Rev 2003, 61:176-179.
14. Kannam JP, Levy D, Larson M, Wilson PW: Short stature and risk for mortality and cardiovascular disease events. The Framingham Heart Study. Circulation 1994, 90:2241-2247.
15. Turner ST, Boerwinkle E, Sing CF: Context-dependent associations of the ACE I/D polymorphism with blood pressure. Hypertension 1999, 34:773-778.
16. Hypponen E, Power C, Smith GD: Prenatal growth, BMI, and risk of type 2 diabetes by early midlife. Diabetes Care 2003, 26:2512-2517.
17. Eriksson J, Lindi V, Uusitupa M, et al.: The effects of the Pro12Ala polymorphism of the PPARgamma-2 gene on lipid metabolism interact with body size at birth. Clin Genet 2003, 64:366-370.
18. Morris BJ, Benjafield AV, Lin RC: Essential hypertension: genes and dreams. Clin Chem Lab Med 2003, 41:834-844.
19. Reich H, Duncan JA, Weinstein J, et al.: Interactions between gender and the angiotensin type 1 receptor gene polymorphism. Kidney Int 2003, 63:1443-1449.
20. Sethi AA, Nordestgaard BG, Tybjaerg-Hansen A: Angiotensinogen gene polymorphism, plasma angiotensinogen, and risk of hypertension and ischemic heart disease: a meta-analysis. Arterioscler Thromb Vasc Biol 2003, 23:1269-1275.
21. Jin JJ, Nakura J, Wu Z, et al.: Association of endothelin-1 gene variant with hypertension. Hypertension 2003, 41:163-167.
22. Pereira AC, Floriano MS, Mota GF, et al.: Beta2 adrenoceptor functional gene variants, obesity, and blood pressure level interactions in the general population. Hypertension 2003, 42:685-692.
23. Acton S, Osgood D, Donoghue M, et al.: Association of polymorphisms at the SR-BI gene locus with plasma lipid levels and body mass index in a white population. Arterioscler Thromb Vasc Biol 1999, 19:1734-1743.
24. Osgood D, Corella D, Demissie S, et al.: Genetic variation at the scavenger receptor class B type I gene locus determines plasma lipoprotein concentrations and particle size and interacts with type 2 diabetes: the Framingham study. J Clin Endocrinol Metab 2003, 88:2869-2879.
25. Albrecht C, Simon-Vermot I, Elliott Ji, et al.: Leukocyte ABCA1 gene expression is associated with fasting glucose concentration in normoglycemic men. Metabolism 2004, 53:17-21.
26. Srinivasan SR, Li S, Chen W, et al.: R219K polymorphism of the ABCA1 gene and its modulation of the variations in serum high-density lipoprotein cholesterol and triglycerides related to age and adiposity in white versus black young adults. The Bogalusa heart study. Metabolism 2003, 52:930-934.
27. Gurnell M: PPARgamma and metabolism: insights from the study of human genetic variants. Clin Endocrinol (Oxford) 2003, 59:267-277.
28. Corella D, Guillen M, Saiz C, et al.: Associations of LPL and APOC3 gene polymorphisms on plasma lipids in a Mediterranean population: interaction with tobacco smoking and the APOE locus. J Lipid Res 2002, 43:416-427.
29. Deeb SS, Zambon A, Carr MC, et al.: Hepatic lipase and dyslipidemia: interactions among genetic variants, obesity, gender, and diet. J Lipid Res 2003, 44:1279-1286.
30. Talmud PJ, Hawe E, Martin S, et al.: Relative contribution of variation within the APOC3/A4/A5 gene cluster in determining plasma triglycerides. Hum Mol Genet 2002, 11:3039-3046.
31. Corella D, Guillen M, Portoles O, et al.: Gender specific associations of the Trp64Arg mutation in the beta3-adrenergic receptor gene with obesity-related phenotypes in a Mediterranean population: interaction with a common lipoprotein lipase gene variation. J Intern Med 2001, 250:348-360.
32. Jezek P: Possible physiological roles of mitochondrial uncoupling proteins-UCPn. Int J Biochem Cell Biol 2002, 34:1190-1206.
33. Proenza AM, Poissonnet CM, Ozata M, et al.: Association of sets of alleles of genes encoding beta3-adrenoreceptor, uncoupling protein 1 and lipoprotein lipase with increased risk of metabolic complications in obesity. Int J Obes Relat Metab Disord 2000, 24:93-100.
34. Jellema A, Mensink RP, Kromhout D, et al.: Metabolic risk markers in an overweight and normal weight population with oversampling of carriers of the IRS-1 972Arg-variant. Atherosclerosis 2003, 171:75-81.
35. Stefan N, Kovacs P, Stumvoll M, et al.: Metabolic effects of the Gly1057Asp polymorphism in IRS-2 and interactions with obesity. Diabetes 2003, 52:1544-1550.
36. Ukkola O, Ravussin E, Jacobson P, et al.: Mutations in the adiponectin gene in lean and obese subjects from the Swedish obese subjects cohort. Metabolism 2003, 52:881-884.
37. Wang H, Chu WS, Hemphill C, Elbein SC: Human resistin gene: molecular scanning and evaluation of association with insulin sensitivity and type 2 diabetes in Caucasians. J Clin Endocrinol Metab 2002, 87:2520-2524.
38. Iwai N, Katsuya T, Mannami T, et al.: Association between SAH, an acyl-CoA synthetase gene, and hypertriglyceridemia, obesity, and hypertension. Circulation 2002, 105:41-47.
39. Dallongeville J, Helbecque N, Cottel D, et al.: The Glyl6-->Arg16 and Gln27-->Glu27 polymorphisms of beta2-adrenergic receptor are associated with metabolic syndrome in men. J Clin Endocrinol Metab 2003, 88:4862-4866.
40. Li G, Chen X, Jang Y, et al.: Obesity, coronary heart disease risk factors and diabetes in Chinese: an approach to the criteria of obesity in the Chinese population. Obes Rev 2002, 3:167-172.
41. Tiret L, Poirier O, Hallet V, et al.: The Lys198Asn polymorphism in the endothelin-1 gene is associated with blood pressure in overweight people. Hypertension 1999, 33:1169-1174.
42. Asai T, Ohkubo T, Katsuya T, et al.: Endothelin-1 gene variant associates with blood pressure in obese Japanese subjects: the Ohasama Study. Hypertension 2001, 38:1321-1324.
43. Mailly F, Fisher RM, Nicaud V, et al.: Association between the LPL-D9N mutation in the lipoprotein lipase gene and plasma lipid traits in myocardial infarction survivors from the ECTIM Study. Atherosclerosis 1996, 122:21-28.
44. Ko YL, Ko YS, Wu SM, et al.: Interaction between obesity and genetic polymorphisms in the apolipoprotein CIII gene and lipoprotein lipase gene on the risk of hypertriglyceridemia in Chinese. Hum Genet 1997, 100:327-333.
45. Ma YQ, Thomas GN, Ng MC, et al.: The lipoprotein lipase gene HindIII polymorphism is associated with lipid levels in early-onset type 2 diabetic patients. Metabolism 2003, 52:338-343.
46. Senti M, Bosch M, Aubo C, et al.: Relationship of abdominal adiposity and dyslipemic status in women with a common mutation in the lipoprotein lipase gene. The REGICOR investigators. Atherosclerosis 2000, 150:135-141.
47. Vohl MC, Lamarche B, Moorjani S, et al.: The lipoprotein lipase HindIII polymorphism modulates plasma triglyceride levels in visceral obesity. Arterioscler Thromb Vasc Biol 1995, 15:714-720.
48. Arca M, Campagna F, Montali A, et al.: The common mutations in the lipoprotein lipase gene in Italy: effects on plasma ipids and angiographically assessed coronary atherosclerosis. Clin Genet 2000, 58:369-374.
49. Ruel IL., Gaudet D, Perron P, et al.: Effect of obesity on HDL and LDL particle sizes in carriers ofthe null P207L or defective D9N mutation in the lipoprotein lipase gene: the Quebec LipD Study. Int J Obes Relat Metab Disord 2003, 27:631-637.
50. Hu FB, Doria A, Li T, et al.: Genetic variation at the adiponectin locus and risk of type 2 diabetes in women. Diabetes 2004, 53:209-213.
51. Strazzullo P, Jacone R, Iacoviello L, et al.: Genetic variation in the renin-angiotensin system and abdominal adiposity in men: the Olivetti Prospective Heart Study. Ann Intern Med 2003, 138:17-23.
52. Tabara Y, Kohara K, Nakura J, Miki T: Risk factor-gene interaction in carotid atherosclerosis: effect of gene polymorphisms of renin-angiotensin system. J Hum Genet 2001, 46:278-284.
53. Elosua R, Demissie S, Cupples LA, et al.: Obesity modulates the association among apoe genotype, insulin, and glucose in men. Obes Res 2003, 11:1502-1508.
54. Ukkola O, Rankinen T, Weisnagel SJ, et al.: Interactions among the alpha2-, beta2-, and beta3-adrenergic receptor genes and obesity-related phenotypes in the Quebec Family Study. Metabolism 2000, 49:1063-1070.
55. Elbein SC, Chu W, Ren Q, et al.: Role of calpain-10 gene variants in familial type 2 diabetes in Caucasians. J Clin Endocrinol Metab 2002, 87:650-654.
56. Hsu LA, Ko YL, Hsu KH, et al.: Genetic variations in the cholesteryl ester transfer protein gene and high density lipoprotein cholesterol levels in Taiwanese Chinese. Hum Genet 2002, 110:57-63.
57. Freeman DJ, Griffin BA, Holmes AP, et al.: Regulation of plasma HDL cholesterol and subfraction distribution by genetic and environmental factors. Associations between the TaqI B RFLP in the CETP gene and smoking and obesity. Arterioscler Thromb 1994, 14:336-344.
58. Heilbronn LK, Noakes M, Clifton PM: Association between HDL-cholesterol and the Taq1B polymorphism in the cholesterol ester transfer protein gene in obese women. Atherosclerosis 2002, 162:419-424.
59. Vohl MC, Lamarche B, Pascot A, et al.: Contribution of the cholesteryl ester transfer protein gene TaqIB polymorphism to the reduced plasma HDL-cholesterol levels found in abdominal obese men with the features of the insulin resistance syndrome. Int J Obes Relat Metab Disord 1999, 23:918-925.
60. Garenc C, Perusse L, Chagnon YC, et al.: The hormone-sensitive lipase gene and body composition: the HERITAGE Family Study. Int J Obes Relat Metab Disord 2002, 26:220-227.
61. Mammarella S, Romano F, Di Valerio A, et al.: Interaction between the G1057D variant of IRS-2 and overweight in the pathogenesis of type 2 diabetes. Hum Mol Genet 2000, 9:2517-2521.
62. St-Pierre J, Miller-Felix I, Paradis ME, et al.: Visceral obesity attenuates the effect of the hepatic lipase -514C>T polymorphism on plasma HDL-cholesterol levels in French-Canadian men. Mol Genet Metab 2003, 78:31-36.
63. St-Pierre J, Lemieux I, Miller-Felix I, et al.: Visceral obesity and hyperinsulinemia modulate the impact ofthe microsomal triglyceride transfer protein -493G/T polymorphism on plasma lipoprotein levels in men. Atherosclerosis 2002, 160:317-324.
64. Meirhaeghe A, Fajas L, Helbecque N, et al.: A genetic polymorphism of the peroxisome proliferator-activated receptor gamma gene influences plasma leptin levels in obese humans. Hum Mol Genet 1998, 7:435-440.
65. Wang H, Chu WS, Hemphill C, Elbein SC: Human resistin gene: molecular scanning and evaluation of association with insulin sensitivity and type 2 diabetes in Caucasians. J Clin Endocrinol Metab 2002, 87:2520-2524.
66. Padovani JC, Pazin-Filho A, Simoes MV, et al.: Gene polymorphisms in the TNF locus and the risk of myocardial infarction. Thromb Res 2000, 100:263-269.
67. Pihlajamaki J, Ylinen M, Karhapaa P, et al.: The effect of the -308A allele of the TNF-alpha gene on insulin action is dependent on obesity. Obes Res 2003, 11:912-917.