Metabolic risk markers in an overweight and normal weight population with oversampling of carriers of the IRS-1 972Arg-variant

Atherosclerosis

Volumn 171, Issue 1, 2003, Pages 75-81

  Jellema, Annemarie ^a,b   Mensink, Ronald P ^b   Kromhout, Daan ^a   Saris, Wim H M ^b   Feskens, Edith J M ^a  

^a NATIONAL INSTITUTE FOR PUBLIC HEALTH AND THE ENVIRONMENT   (Netherlands)

^b MAASTRICHT UNIVERSITY   (Netherlands)

Author keywords

Genetic associations; Gly972Arg; Insulin resistance; IRS 1; Obesity; Serum lipids

Indexed keywords

ARGININE; GLUCOSE; INSULIN; INSULIN RECEPTOR SUBSTRATE 1; LIPID; TRIACYLGLYCEROL;

ADULT; AGE; ALCOHOL CONSUMPTION; ARTICLE; BODY MASS; CIGARETTE SMOKING; COHORT ANALYSIS; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DIET RESTRICTION; DNA POLYMORPHISM; FEMALE; GENOTYPE; GLUCOSE BLOOD LEVEL; HUMAN; INSULIN BLOOD LEVEL; LIPID BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; OBESITY; PHYSICAL ACTIVITY; PRIORITY JOURNAL; SEX; STATISTICAL SIGNIFICANCE; TRIACYLGLYCEROL BLOOD LEVEL;

EID: 0345714692     PISSN: 00219150     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.atherosclerosis.2003.08.002     Document Type: Article

References (29)

1. White M.F., Kahn C.R. The insulin signaling system. J. Biol. Chem. 269:1994;1-4.
2. Sesti G., Federici M., Hribal M.L., Lauro D., Sbraccia P., Lauro R. Defects of the insulin receptor substrate (IRS) system in human metabolic disorders. FASEB J. 15:2001;2099-2111.
3. Jellema A, Zeegers MP, Feskens EJ, Dagnelie PC, Mensink RP. Gly972Arg variant in the insulin receptor substrate-1 gene and association with Type 2 diabetes: a meta-analysis of 27 studies. Diabetologia 2003 (Online First, published June 18, 2003).
4. Almind K. Aminoacid polymorphisms of insulin receptor substrate-1 in non-insulin-dependent diabetes mellitus. Lancet. 342:1993;828-832.
5. Baroni M.G., Arca M., Sentinelli F.et al. The G972R variant of the insulin receptor substrate-1 (IRS-1) gene, body fat distribution and insulin-resistance. Diabetologia. 44:2001;367-372.
6. Baroni M.G., D'Andrea M.P., Montali A.et al. A common mutation of the insulin receptor substrate-1 gene is a risk factor for coronary artery disease. Arterioscler. Thromb. Vasc. Biol. 19:1999;2975-2980.
7. Clausen J.O., Hansen T., Bjørbaek C.et al. Insulin resistance: interactions between obesity and a common variant of insulin receptor substrate-1. Lancet. 346:1995;397-402.
8. Laakso M., Malkki M., Kekäläinen P., Kuusisto J., Deeb S.S. Insulin receptor substrate-1 variants in non-insulin-dependent diabetes. J. Clin. Invest. 94:1994;1141-1146.
9. Ossei-Gerning N., Mansfield M.W., Stickland M.H., Grant P.J. Insulin receptor substrate-1 gene polymorphism and cardiovascular risk in non-insulin dependent diabetes mellitus and patients undergoing coronary angiography. Clin. Lab. Haem. 19:1997;123-128.
10. Zhang Y., Stratton I.M., Warren-Perry M.G., Orho M., Groop L., Turner R.C. UKPDS 19: heterogeneity in NIDDM: separate contributions of IRS-1 and beta3-adrenergic-receptor mutations to insulin resistance and obesity respectively with no evidence for glycogen synthase gene mutations. Diabetologia. 39:1996;1505-1511.
11. Verschuren W.M.M., van Leer E.M., Blokstra A.et al. Cardiovascular disease risk factors in The Netherlands. Neth. J. Cardiol. 4:1993;205-210.
12. van Dam R.M., Boer J.M., Feskens E.J., Seidell J.C. Parental history of diabetes modifies the association between abdominal adiposity and hyperglycemia. Diabetes Care. 24:2001;1454-1459.
13. Miller S.A., Dykes D.D., Polesky H.F. A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res. 16:1988;1215.
14. Friedewald W.T., Levy R.I., Fredrickson D.S. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin. Chem. 18:1972;499-502.
15. Matthews D.R., Hosker J.P., Rudenski A.S., Naylor B.A., Treacher D.F., Turner R.C. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 28:1985;412-419.
16. Almind K., Inoue G., Pedersen O., Kahn R.K. A common amino acid polymorphism in insulin receptor substrate-1 causes impaired insulin signaling. J. Clin. Invest. 97:1996;2569-2575.
17. Sigal R.J., Doria A., Warram J.H., Krolewski A.S. Codon 972 polymorphism in the insulin receptor substrate-1 gene, obesity, and risk of noninsulin-dependent diabetes mellitus. J. Clin. Endocrinol. Metab. 81:1996;1657-1659.
18. Howard B.V. Insulin resistance and lipid metabolism. Am. J. Cardiol. 84:1999;28J-32J.
19. Phung T.L., Roncone A., Jensen K.L., Sparks C.E., Sparks J.D. Phosphoinositide 3-kinase activity is necessary for insulin-dependent inhibition of apolipoprotein B secretion by rat hepatocytes and localizes to the endoplasmic reticulum. J. Biol. Chem. 272:1997;30693-30702.
20. Previs S.F., Withers D.J., Ren J.M., White M.F., Shulman G.I. Contrasting effects of IRS-1 versus IRS-2 gene disruption on carbohydrate and lipid metabolism in vivo. J. Biol. Chem. 275:2000;38990-38994.
21. Sparks J.D., Sparks C.E. Insulin regulation of triacylglycerol-rich lipoprotein synthesis and secretion. Biochim. Biophys. Acta. 1215:1994;9-32.
22. Stumvoll M., Fritsche A., Volk A.et al. The Gly972Arg polymorphism in the insulin receptor substrate-1 gene contributes to the variation in insulin secretion in normal glucose-tolerant humans. Diabetes. 50:2001;882-885.
23. 't Hart L.M., Nijpels G., Dekker J.M., Maassen J.A., Heine R.J., van Haeften T.W. Variations in insulin secretion in carriers of gene variants in IRS-1 and -2. Diabetes. 51:2002;884-887.
24. Ruige J.B., Dekker J.M., Nijpels G.et al. Hyperproinsulinaemia in impaired glucose tolerance is associated with a delayed insulin response to glucose. Diabetologia. 42:1999;177-180.
25. Reaven G.M. Non-insulin-dependent diabetes mellitus, abnormal lipoprotein metabolism, and atherosclerosis. Metabolism. 36:1987;1-8.
26. Reaven G.M., Chen Y.-D.I., Jeppesen J., Maheux P., Krauss R.M. Insulin resistance and hyperinsulinemia in individuals with small, dense, low density lipoprotein particles. J. Clin. Invest. 92:1993;141-146.
27. Stumvoll M., Stefan N., Fritsche A.et al. Interaction effect between common polymorphisms in PPARgamma(2) (Pro12Ala) and insulin receptor substrate 1 (Gly972Arg) on insulin sensitivity. J. Mol. Med. 80:2002;33-38.
28. Lei H.H., Coresh J., Shuldiner A.R., Boerwinkle E., Brancati F.L. Variants of the insulin receptor substrate-1 and fatty acid binding protein 2 genes and the risk of type 2 diabetes, obesity, and hyperinsulinemia in African-Americans: the atherosclerosis risk in communities study. Diabetes. 48:1999;1868-1872.
29. 't Hart L.M., Stolk R.P., Dekker J.M.et al. Prevalence of variants in candidate genes for type 2 diabetes mellitus in The Netherlands: the Rotterdam study and the Hoorn study. J. Clin. Endocrinol. Metab. 84:1999;1002-1006.