메뉴 건너뛰기




Volumn 46, Issue 2, 2004, Pages 162-169

Regenerative medicine in andrology: Tissue engineering and gene therapy as potential treatment options for penile deformations and erectile dysfunction

Author keywords

Andrology; Erectile dysfunction; Gene therapy; Penile deformation; Tissue engineering

Indexed keywords

ADENOVIRUS VECTOR; ANDROGEN; ANTISENSE OLIGONUCLEOTIDE; CALCITONIN GENE RELATED PEPTIDE; GROWTH FACTOR; NERVE GROWTH FACTOR; NEUROTROPHIC FACTOR; NITRIC OXIDE SYNTHASE; PLASMID DNA; POTASSIUM; POTASSIUM CHANNEL; PROTEIN INHIBITOR; RETROVIRUS VECTOR; RHO KINASE; SILICONE; SOMATOMEDIN; SUPEROXIDE DISMUTASE; VASCULOTROPIN; VIRUS VECTOR;

EID: 3142574863     PISSN: 03022838     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.eururo.2004.02.001     Document Type: Review
Times cited : (13)

References (68)
  • 1
    • 0141993748 scopus 로고    scopus 로고
    • Regenerative medicine and urology
    • Atala A. Regenerative medicine and urology. BJU Int. 92(Suppl 1):2003;58-67
    • (2003) BJU Int. , vol.92 , Issue.SUPPL. 1 , pp. 58-67
    • Atala, A.1
  • 2
    • 0037488366 scopus 로고    scopus 로고
    • Tissue engineering and stem cell research in urology
    • Cross W.R., Thomas D.F., Southgate J. Tissue engineering and stem cell research in urology. BJU Int. 92:2003;165-171
    • (2003) BJU Int. , vol.92 , pp. 165-171
    • Cross, W.R.1    Thomas, D.F.2    Southgate, J.3
  • 3
    • 0442323419 scopus 로고    scopus 로고
    • Flap technology for reconstructions of urogenital organs
    • Ninkovic M., Dabernig W. Flap technology for reconstructions of urogenital organs. Curr. Opin. Urol. 13:2003;483-488
    • (2003) Curr. Opin. Urol. , vol.13 , pp. 483-488
    • Ninkovic, M.1    Dabernig, W.2
  • 4
    • 0442276323 scopus 로고    scopus 로고
    • Vaginal and penile reconstruction
    • Sievert K.D. Vaginal and penile reconstruction. Curr. Opin. Urol. 13:2003;489-494
    • (2003) Curr. Opin. Urol. , vol.13 , pp. 489-494
    • Sievert, K.D.1
  • 5
    • 0036587089 scopus 로고    scopus 로고
    • Experimental and clinical experience with tissue engineering techniques for urethral reconstruction
    • Atala A. Experimental and clinical experience with tissue engineering techniques for urethral reconstruction. Urol Clin North Am 2002;29:485-92, ix.
    • (2002) Urol Clin North Am , vol.29 , pp. 485-492
    • Atala, A.1
  • 7
    • 0036019368 scopus 로고    scopus 로고
    • Reconstitution of human corpus cavernosum smooth muscle in vitro and in vivo
    • Kershen R.T., Yoo J.J., Moreland R.B., Krane R.J., Atala A. Reconstitution of human corpus cavernosum smooth muscle in vitro and in vivo. Tissue Eng. 8:2002;515-524
    • (2002) Tissue Eng. , vol.8 , pp. 515-524
    • Kershen, R.T.1    Yoo, J.J.2    Moreland, R.B.3    Krane, R.J.4    Atala, A.5
  • 8
    • 0001098627 scopus 로고    scopus 로고
    • Reconstitution of human corporal smooth muscle and endothelial cells in vivo
    • Park H.J., Yoo J.J., Kershen R.T., Moreland R., Atala A. Reconstitution of human corporal smooth muscle and endothelial cells in vivo. J. Urol. 162:1999;1106-1109
    • (1999) J. Urol. , vol.162 , pp. 1106-1109
    • Park, H.J.1    Yoo, J.J.2    Kershen, R.T.3    Moreland, R.4    Atala, A.5
  • 9
    • 0142062593 scopus 로고    scopus 로고
    • Formation of corporal tissue architecture in vivo using human cavernosal muscle and endothelial cells seeded on collagen matrices
    • Falke G., Yoo J.J., Kwon T.G., Moreland R., Atala A. Formation of corporal tissue architecture in vivo using human cavernosal muscle and endothelial cells seeded on collagen matrices. Tissue Eng. 9:2003;871-879
    • (2003) Tissue Eng. , vol.9 , pp. 871-879
    • Falke, G.1    Yoo, J.J.2    Kwon, T.G.3    Moreland, R.4    Atala, A.5
  • 10
    • 0036783590 scopus 로고    scopus 로고
    • Autologous penile corpora cavernosa replacement using tissue engineering techniques
    • Kwon T.G., Yoo J.J., Atala A. Autologous penile corpora cavernosa replacement using tissue engineering techniques. J. Urol. 168:2002;1754-1758
    • (2002) J. Urol. , vol.168 , pp. 1754-1758
    • Kwon, T.G.1    Yoo, J.J.2    Atala, A.3
  • 11
    • 0442292063 scopus 로고    scopus 로고
    • Nerve regeneration: Might this be the only solution for functional problems of the urinary tract?
    • Biers S.M., Brading A.F. Nerve regeneration: might this be the only solution for functional problems of the urinary tract? Curr. Opin. Urol. 13:2003;495-500
    • (2003) Curr. Opin. Urol. , vol.13 , pp. 495-500
    • Biers, S.M.1    Brading, A.F.2
  • 12
    • 0036883670 scopus 로고    scopus 로고
    • Principals of neovascularization for tissue engineering
    • Nomi M., Atala A., Coppi P.D., Soker S. Principals of neovascularization for tissue engineering. Mol. Aspects Med. 23:2002;463-483
    • (2002) Mol. Aspects Med. , vol.23 , pp. 463-483
    • Nomi, M.1    Atala, A.2    Coppi, P.D.3    Soker, S.4
  • 13
    • 0032721202 scopus 로고    scopus 로고
    • Endothelial cell transplantation into the corpus cavernosum: Moving towards cell-based gene therapy
    • Wessells H., Williams S.K. Endothelial cell transplantation into the corpus cavernosum: moving towards cell-based gene therapy. J. Urol. 162:1999;2162-2164
    • (1999) J. Urol. , vol.162 , pp. 2162-2164
    • Wessells, H.1    Williams, S.K.2
  • 16
    • 0035078843 scopus 로고    scopus 로고
    • Nitric oxide synthase gene therapy for erectile dysfunction: Comparison of plasmid, adenovirus, and adenovirus-transduced myoblast vectors
    • Tirney S., Mattes C.E., Yoshimura N., Yokayama T., Ozawa H., Tzeng E., et al. Nitric oxide synthase gene therapy for erectile dysfunction: comparison of plasmid, adenovirus, and adenovirus-transduced myoblast vectors. Mol. Urol. 5:2001;37-43
    • (2001) Mol. Urol. , vol.5 , pp. 37-43
    • Tirney, S.1    Mattes, C.E.2    Yoshimura, N.3    Yokayama, T.4    Ozawa, H.5    Tzeng, E.6
  • 17
    • 0032324183 scopus 로고    scopus 로고
    • Cartilage rods as a potential material for penile reconstruction
    • Yoo JJ, Lee I, Atala A. Cartilage rods as a potential material for penile reconstruction. J Urol 1998;160:1164-8 [Discussion 1178].
    • (1998) J Urol , vol.160 , pp. 1164-1168
    • Yoo, J.J.1    Lee, I.2    Atala, A.3
  • 18
    • 0032832039 scopus 로고    scopus 로고
    • Autologous engineered cartilage rods for penile reconstruction
    • Yoo J.J., Park H.J., Lee I., Atala A. Autologous engineered cartilage rods for penile reconstruction. J. Urol. 162:1999;1119-1121
    • (1999) J. Urol. , vol.162 , pp. 1119-1121
    • Yoo, J.J.1    Park, H.J.2    Lee, I.3    Atala, A.4
  • 19
    • 0036783988 scopus 로고    scopus 로고
    • Engineering of human cartilage rods: Potential application for penile prostheses
    • Kim B.S., Yoo J.J., Atala A. Engineering of human cartilage rods: potential application for penile prostheses. J. Urol. 168:2002;1794-1797
    • (2002) J. Urol. , vol.168 , pp. 1794-1797
    • Kim, B.S.1    Yoo, J.J.2    Atala, A.3
  • 20
    • 3142614094 scopus 로고
    • On complete plastic reconstruction of a penis sufficient for coitus [in Russian]
    • Bogoraz N.A. On complete plastic reconstruction of a penis sufficient for coitus [in Russian]. Soviet Surgery [Sovetskaya khirurgiya]. 8:1936;303-309
    • (1936) Soviet Surgery [Sovetskaya Khirurgiya] , vol.8 , pp. 303-309
    • Bogoraz, N.A.1
  • 23
    • 0036803417 scopus 로고    scopus 로고
    • Peyronie's disease: Surgical management: Autologous materials
    • Carson C.C., Chun J.L. Peyronie's disease: surgical management: autologous materials. Int. J. Impot. Res. 14:2002;329-335
    • (2002) Int. J. Impot. Res. , vol.14 , pp. 329-335
    • Carson, C.C.1    Chun, J.L.2
  • 24
    • 0036555345 scopus 로고    scopus 로고
    • Collagen fleece for defect coverage following plaque excision in patients with Peyronie's disease
    • Lahme S., Gotz T., Bichler K.H. Collagen fleece for defect coverage following plaque excision in patients with Peyronie's disease. Eur. Urol. 41:2002;401-405
    • (2002) Eur. Urol. , vol.41 , pp. 401-405
    • Lahme, S.1    Gotz, T.2    Bichler, K.H.3
  • 25
    • 0036375610 scopus 로고    scopus 로고
    • Tunica albuginea acellular matrix graft for penile reconstruction in the rabbit: A model for treating Peyronie's disease
    • Wefer J., Schlote N., Sekido N., Sievert K.D., Wefer A.E., Nunes L., et al. Tunica albuginea acellular matrix graft for penile reconstruction in the rabbit: a model for treating Peyronie's disease. BJU Int. 90:2002;326-331
    • (2002) BJU Int. , vol.90 , pp. 326-331
    • Wefer, J.1    Schlote, N.2    Sekido, N.3    Sievert, K.D.4    Wefer, A.E.5    Nunes, L.6
  • 26
    • 0041815946 scopus 로고    scopus 로고
    • Complications of small intestinal submucosa for corporal body grafting for proximal hypospadias
    • Soergel TM, Cain MP, Kaefer M, Gitlin J, Casale AJ, Davis MM, et al. Complications of small intestinal submucosa for corporal body grafting for proximal hypospadias. J Urol 2003;170:1577-8; 1578-9.
    • (2003) J Urol , vol.170 , pp. 1577-1578
    • Soergel, T.M.1    Cain, M.P.2    Kaefer, M.3    Gitlin, J.4    Casale, A.J.5    Davis, M.M.6
  • 27
    • 3142643789 scopus 로고    scopus 로고
    • Functional tissue engineering of autologous tunica albuginea: A possible graft for Peyronie's disease surgery
    • [Abstract 483].
    • Schultheiss D, Lorenz RR, Gabouev AI, Schlote N, Wefer J, Mertsching H, et al. Functional tissue engineering of autologous tunica albuginea: a possible graft for Peyronie's disease surgery. Eur Urol Suppl 2003;2(1):123 [Abstract 483].
    • (2003) Eur Urol Suppl , vol.2 , Issue.1 , pp. 123
    • Schultheiss, D.1    Lorenz, R.R.2    Gabouev, A.I.3    Schlote, N.4    Wefer, J.5    Mertsching, H.6
  • 28
    • 0037323179 scopus 로고    scopus 로고
    • Erectile function after radical prostatectomy: A review
    • [Editorial Comment by F. Montorsi 101-2].
    • Meuleman EJ, Mulders PF. Erectile function after radical prostatectomy: a review. Eur Urol 2003;43:95-101 [Editorial Comment by F. Montorsi 101-2].
    • (2003) Eur Urol , vol.43 , pp. 95-101
    • Meuleman, E.J.1    Mulders, P.F.2
  • 29
    • 0038825116 scopus 로고    scopus 로고
    • Neuroprotection and nerve grafts in the treatment of neurogenic erectile dysfunction
    • Burnett AL. Neuroprotection and nerve grafts in the treatment of neurogenic erectile dysfunction. J Urol 2003;170:S31-4 [Discussion S34].
    • (2003) J Urol , vol.170
    • Burnett, A.L.1
  • 30
    • 0026020077 scopus 로고
    • Cavernous nerve grafts restore erectile function in denervated rats
    • Quinlan D.M., Nelson R.J., Walsh P.C. Cavernous nerve grafts restore erectile function in denervated rats. J. Urol. 145:1991;380-383
    • (1991) J. Urol. , vol.145 , pp. 380-383
    • Quinlan, D.M.1    Nelson, R.J.2    Walsh, P.C.3
  • 31
    • 0035023137 scopus 로고    scopus 로고
    • Nerve grafts are rarely necessary and are unlikely to improve sexual function in men undergoing anatomic radical prostatectomy
    • Walsh P.C. Nerve grafts are rarely necessary and are unlikely to improve sexual function in men undergoing anatomic radical prostatectomy. Urology. 57:2001;1020-1024
    • (2001) Urology , vol.57 , pp. 1020-1024
    • Walsh, P.C.1
  • 32
    • 3142614096 scopus 로고    scopus 로고
    • Schwann cell grafts are superior to autologous nerve grafts for repair of ablated cavernosal nerves in rats
    • [Abstract 278].
    • May F, Weidner N, Mrva T, Caspers C, Gänsbacher B, Hartung R. Schwann cell grafts are superior to autologous nerve grafts for repair of ablated cavernosal nerves in rats. Eur Urol Suppl 2003;2(1):72 [Abstract 278].
    • (2003) Eur Urol Suppl , vol.2 , Issue.1 , pp. 72
    • May, F.1    Weidner, N.2    Mrva, T.3    Caspers, C.4    Gänsbacher, B.5    Hartung, R.6
  • 33
    • 24844458096 scopus 로고    scopus 로고
    • GDNF-hypersecreting Schwann cells enhance regeneration of erectile nerves in rats
    • May F., Weidner N., Caspers C., Mrva T., Matiasek K., Gänsbacher B., et al. GDNF-hypersecreting Schwann cells enhance regeneration of erectile nerves in rats. Urologe A. 42:2003;S26
    • (2003) Urologe a , vol.42 , pp. 26
    • May, F.1    Weidner, N.2    Caspers, C.3    Mrva, T.4    Matiasek, K.5    Gänsbacher, B.6
  • 34
    • 0042411135 scopus 로고    scopus 로고
    • The effect of vascular endothelial growth factor and brain-derived neurotrophic factor on cavernosal nerve regeneration in a nerve-crush rat model
    • Hsieh P.S., Bochinski D.J., Lin G.T., Nunes L., Lin C.S., Lue T.F. The effect of vascular endothelial growth factor and brain-derived neurotrophic factor on cavernosal nerve regeneration in a nerve-crush rat model. BJU Int. 92:2003;470-475
    • (2003) BJU Int. , vol.92 , pp. 470-475
    • Hsieh, P.S.1    Bochinski, D.J.2    Lin, G.T.3    Nunes, L.4    Lin, C.S.5    Lue, T.F.6
  • 35
    • 0034980979 scopus 로고    scopus 로고
    • The effect of adeno-associated virus mediated brain derived neurotrophic factor in an animal model of neurogenic impotence
    • Bakircioglu M.E., Lin C.S., Fan P., Sievert K.D., Kan Y.W., Lue T.F. The effect of adeno-associated virus mediated brain derived neurotrophic factor in an animal model of neurogenic impotence. J. Urol. 165:2001;2103-2109
    • (2001) J. Urol. , vol.165 , pp. 2103-2109
    • Bakircioglu, M.E.1    Lin, C.S.2    Fan, P.3    Sievert, K.D.4    Kan, Y.W.5    Lue, T.F.6
  • 36
    • 0037376430 scopus 로고    scopus 로고
    • The effect of vascular endothelial growth factor and adeno-associated virus mediated brain derived neurotrophic factor on neurogenic and vasculogenic erectile dysfunction induced by hyperlipidemia
    • Gholami S.S., Rogers R., Chang J., Ho H.C., Grazziottin T., Lin C.S., et al. The effect of vascular endothelial growth factor and adeno-associated virus mediated brain derived neurotrophic factor on neurogenic and vasculogenic erectile dysfunction induced by hyperlipidemia. J. Urol. 169:2003;1577-1581
    • (2003) J. Urol. , vol.169 , pp. 1577-1581
    • Gholami, S.S.1    Rogers, R.2    Chang, J.3    Ho, H.C.4    Grazziottin, T.5    Lin, C.S.6
  • 37
    • 0742281366 scopus 로고    scopus 로고
    • Neurotrophic factor gene therapy: Potential cure for post radical prostatectomy erectile dysfunction
    • Kim J.H., Bennett N.E., Sasaki K., Yoshimura N., Wolfe D.P., Goins W.F., et al. Neurotrophic factor gene therapy: potential cure for post radical prostatectomy erectile dysfunction. J. Urol. 169(Suppl):2003;303-304
    • (2003) J. Urol. , vol.169 , Issue.SUPPL. , pp. 303-304
    • Kim, J.H.1    Bennett, N.E.2    Sasaki, K.3    Yoshimura, N.4    Wolfe, D.P.5    Goins, W.F.6
  • 38
    • 0035110530 scopus 로고    scopus 로고
    • Potential application of gene therapy for the treatment of erectile dysfunction
    • Bivalacqua T.J., Hellstrom W.J. Potential application of gene therapy for the treatment of erectile dysfunction. J. Androl. 22:2001;183-190
    • (2001) J. Androl. , vol.22 , pp. 183-190
    • Bivalacqua, T.J.1    Hellstrom, W.J.2
  • 39
    • 0142246427 scopus 로고    scopus 로고
    • Frontiers in gene therapy for erectile dysfunction
    • Christ G.J. Frontiers in gene therapy for erectile dysfunction. Int. J. Impot. Res. 15(Suppl 5):2003;S33-S40
    • (2003) Int. J. Impot. Res. , vol.15 , Issue.SUPPL. 5 , pp. 33-S40
    • Christ, G.J.1
  • 40
    • 3142573709 scopus 로고    scopus 로고
    • Proof of concept of using the bio-bolistic gene transfer (gene gun) to the rat penis
    • Tyagi P., Chancellor M.B., Yoshimura N., Kim J.H., Bennett N.E., Huang L. Proof of concept of using the bio-bolistic gene transfer (gene gun) to the rat penis. J. Urol. 169(Suppl):2003;307
    • (2003) J. Urol. , vol.169 , Issue.SUPPL. , pp. 307
    • Tyagi, P.1    Chancellor, M.B.2    Yoshimura, N.3    Kim, J.H.4    Bennett, N.E.5    Huang, L.6
  • 41
    • 0031834590 scopus 로고    scopus 로고
    • The application of gene therapy to the treatment of erectile dysfunction
    • Christ G.J., Melman A. The application of gene therapy to the treatment of erectile dysfunction. Int. J. Impot. Res. 10:1998;111-112
    • (1998) Int. J. Impot. Res. , vol.10 , pp. 111-112
    • Christ, G.J.1    Melman, A.2
  • 42
    • 0030978643 scopus 로고    scopus 로고
    • Cloning of rat and human inducible penile nitric oxide synthase. Application for gene therapy of erectile dysfunction
    • Garban H., Marquez D., Magee T., Moody J., Rajavashisth T., Rodriguez J.A., et al. Cloning of rat and human inducible penile nitric oxide synthase. Application for gene therapy of erectile dysfunction. Biol. Reprod. 56:1997;954-963
    • (1997) Biol. Reprod. , vol.56 , pp. 954-963
    • Garban, H.1    Marquez, D.2    Magee, T.3    Moody, J.4    Rajavashisth, T.5    Rodriguez, J.A.6
  • 43
    • 0142167275 scopus 로고    scopus 로고
    • Enhancement of physiologic erectile dysfunction with nitric oxide synthase gene therapy
    • Rehman J., Christ G., Melman A., Werber J., Alyskewycz M., Staerman F., et al. Enhancement of physiologic erectile dysfunction with nitric oxide synthase gene therapy. J. Urol. 157(Suppl):1997;201
    • (1997) J. Urol. , vol.157 , Issue.SUPPL. , pp. 201
    • Rehman, J.1    Christ, G.2    Melman, A.3    Werber, J.4    Alyskewycz, M.5    Staerman, F.6
  • 44
    • 0036085756 scopus 로고    scopus 로고
    • Gene therapy of erectile dysfunction in the rat with penile neuronal nitric oxide synthase
    • Magee T.R., Ferrini M., Garban H.J., Vernet D., Mitani K., Rajfer J., et al. Gene therapy of erectile dysfunction in the rat with penile neuronal nitric oxide synthase. Biol. Reprod. 67:2002;1033-1041
    • (2002) Biol. Reprod. , vol.67 , pp. 1033-1041
    • Magee, T.R.1    Ferrini, M.2    Garban, H.J.3    Vernet, D.4    Mitani, K.5    Rajfer, J.6
  • 45
    • 0742316318 scopus 로고    scopus 로고
    • Gene transfer of antisense PIN (protein inhibitor of NOS cDNA) ameliorates aging-related erectile dysfunction in the rat
    • Magee T., Davila H.H., Ferrini M.G., Raijfer J., Gonzalez-Cadavid N.F. Gene transfer of antisense PIN (protein inhibitor of NOS cDNA) ameliorates aging-related erectile dysfunction in the rat. J. Urol. 169(Suppl):2003;305
    • (2003) J. Urol. , vol.169 , Issue.SUPPL. , pp. 305
    • Magee, T.1    Davila, H.H.2    Ferrini, M.G.3    Raijfer, J.4    Gonzalez-Cadavid, N.F.5
  • 47
    • 0034522064 scopus 로고    scopus 로고
    • Adenoviral gene transfer of endothelial nitric oxide synthase (eNOS) to the penis improves age-related erectile dysfunction in the rat
    • Bivalacqua T.J., Champion H.C., Mehta Y.S., Abdel-Mageed A.B., Sikka S.C., Ignarro L.J., et al. Adenoviral gene transfer of endothelial nitric oxide synthase (eNOS) to the penis improves age-related erectile dysfunction in the rat. Int. J. Impot. Res. 12(Suppl 3):2000;S8-17
    • (2000) Int. J. Impot. Res. , vol.12 , Issue.SUPPL. 3 , pp. 8-17
    • Bivalacqua, T.J.1    Champion, H.C.2    Mehta, Y.S.3    Abdel-Mageed, A.B.4    Sikka, S.C.5    Ignarro, L.J.6
  • 48
    • 0037404943 scopus 로고    scopus 로고
    • Gene transfer of endothelial nitric oxide synthase partially restores nitric oxide synthesis and erectile function in streptozotocin diabetic rats
    • Bivalacqua T.J., Usta M.F., Champion H.C., Adams D., Namara D.B., Abdel-Mageed A.B., et al. Gene transfer of endothelial nitric oxide synthase partially restores nitric oxide synthesis and erectile function in streptozotocin diabetic rats. J. Urol. 169:2003;1911-1917
    • (2003) J. Urol. , vol.169 , pp. 1911-1917
    • Bivalacqua, T.J.1    Usta, M.F.2    Champion, H.C.3    Adams, D.4    Namara, D.B.5    Abdel-Mageed, A.B.6
  • 49
    • 0036725094 scopus 로고    scopus 로고
    • K channels as molecular targets for the treatment of erectile dysfunction
    • Christ G.J. K channels as molecular targets for the treatment of erectile dysfunction. J. Androl. 23:2002;S10-S19
    • (2002) J. Androl. , vol.23 , pp. 10-S19
    • Christ, G.J.1
  • 50
    • 0031827271 scopus 로고    scopus 로고
    • Intracorporal injection of hSlo cDNA in rats produces physiologically relevant alterations in penile function
    • Christ G.J., Rehman J., Day N., Salkoff L., Valcic M., Melman A., et al. Intracorporal injection of hSlo cDNA in rats produces physiologically relevant alterations in penile function. Am. J. Physiol. 275:1998;H600-H608
    • (1998) Am. J. Physiol. , vol.275 , pp. 600-H608
    • Christ, G.J.1    Rehman, J.2    Day, N.3    Salkoff, L.4    Valcic, M.5    Melman, A.6
  • 51
    • 0038340638 scopus 로고    scopus 로고
    • The successful long-term treatment of age related erectile dysfunction with hSlo cDNA in rats in vivo
    • Melman A., Zhao W., Davies K.P., Bakal R., Christ G.J. The successful long-term treatment of age related erectile dysfunction with hSlo cDNA in rats in vivo. J. Urol. 170:2003;285-290
    • (2003) J. Urol. , vol.170 , pp. 285-290
    • Melman, A.1    Zhao, W.2    Davies, K.P.3    Bakal, R.4    Christ, G.J.5
  • 52
    • 3142533498 scopus 로고    scopus 로고
    • Ex vivo gene transfer of KATP channel produces physiological alterations in corporal smooth muscle cells
    • Lee S.W., Chae M.R., Kim S.H., So I. Ex vivo gene transfer of KATP channel produces physiological alterations in corporal smooth muscle cells. Int. J. Impot. Res. 15(Suppl 6):2003;S2
    • (2003) Int. J. Impot. Res. , vol.15 , Issue.SUPPL. 6 , pp. 2
    • Lee, S.W.1    Chae, M.R.2    Kim, S.H.3    So, I.4
  • 54
  • 56
    • 0037300192 scopus 로고    scopus 로고
    • Intracavernosal vascular endothelial growth factor (VEGF) injection and adeno-associated virus-mediated VEGF gene therapy prevent and reverse venogenic erectile dysfunction in rats
    • Rogers R.S., Graziottin T.M., Lin C.S., Kan Y.W., Lue T.F. Intracavernosal vascular endothelial growth factor (VEGF) injection and adeno-associated virus-mediated VEGF gene therapy prevent and reverse venogenic erectile dysfunction in rats. Int. J. Impot. Res. 15:2003;26-37
    • (2003) Int. J. Impot. Res. , vol.15 , pp. 26-37
    • Rogers, R.S.1    Graziottin, T.M.2    Lin, C.S.3    Kan, Y.W.4    Lue, T.F.5
  • 57
    • 3142531480 scopus 로고    scopus 로고
    • Angiogenic factors for therapy of ED: Protein and DNA transfer of VEGF in the rat penis
    • Burchardt M., Burchardt T., Buttyan R., Anastasiadis A., De La Taille A., Shabsigh A., et al. Angiogenic factors for therapy of ED: protein and DNA transfer of VEGF in the rat penis. J. Urol. 169(Suppl):2003;309-310
    • (2003) J. Urol. , vol.169 , Issue.SUPPL. , pp. 309-310
    • Burchardt, M.1    Burchardt, T.2    Buttyan, R.3    Anastasiadis, A.4    De La Taille, A.5    Shabsigh, A.6
  • 58
    • 3142567537 scopus 로고    scopus 로고
    • Effects of intracavernosal IGF-1 gene delivery on erectile function in the aging rat
    • Park K., Ahn K., Kim K.K., Kim M.K., Ryu S.B. Effects of intracavernosal IGF-1 gene delivery on erectile function in the aging rat. Int. J. Impot. Res. 15:2003;S35
    • (2003) Int. J. Impot. Res. , vol.15 , pp. 35
    • Park, K.1    Ahn, K.2    Kim, K.K.3    Kim, M.K.4    Ryu, S.B.5
  • 59
    • 0037316102 scopus 로고    scopus 로고
    • Antisense oligonucleotide therapy for urologic tumors
    • Kausch I., Bohle A. Antisense oligonucleotide therapy for urologic tumors. Curr. Urol. Rep. 4:2003;60-69
    • (2003) Curr. Urol. Rep. , vol.4 , pp. 60-69
    • Kausch, I.1    Bohle, A.2
  • 60
    • 3142607812 scopus 로고    scopus 로고
    • Potential roles of antisense therapy in the molecular targeting of genes involved in cancer (review)
    • Kim R., Tanabe K., Emi M., Uchida Y., Toge T. Potential roles of antisense therapy in the molecular targeting of genes involved in cancer (review). Int. J. Oncol. 24:2004;5-17
    • (2004) Int. J. Oncol. , vol.24 , pp. 5-17
    • Kim, R.1    Tanabe, K.2    Emi, M.3    Uchida, Y.4    Toge, T.5
  • 61
    • 0036043738 scopus 로고    scopus 로고
    • The effects of antisenes oligodeoxynucleotide on the cyclic nucleotide monophosphates in smooth muscle cells of human corpus cavernosum
    • Bai W.J., Hou S.K., Wang X.F., Yan Z., He P.Y., Deng Q.P., et al. The effects of antisenes oligodeoxynucleotide on the cyclic nucleotide monophosphates in smooth muscle cells of human corpus cavernosum. Zhonghua Nan Ke Xue. 8:2002;88-91
    • (2002) Zhonghua Nan Ke Xue , vol.8 , pp. 88-91
    • Bai, W.J.1    Hou, S.K.2    Wang, X.F.3    Yan, Z.4    He, P.Y.5    Deng, Q.P.6
  • 62
    • 0036855397 scopus 로고    scopus 로고
    • A systematic approach to erectile dysfunction in the cardiovascular patient: A Consensus Statement - Update 2002
    • Jackson G., Betteridge J., Dean J., Eardley I., Hall R., Holdright D., et al. A systematic approach to erectile dysfunction in the cardiovascular patient: a Consensus Statement - update 2002. Int. J. Clin. Pract. 56:2002;663-671
    • (2002) Int. J. Clin. Pract. , vol.56 , pp. 663-671
    • Jackson, G.1    Betteridge, J.2    Dean, J.3    Eardley, I.4    Hall, R.5    Holdright, D.6
  • 63
    • 0037752795 scopus 로고    scopus 로고
    • Is erectile dysfunction the "tip of the iceberg" of a systemic vascular disorder?
    • Montorsi P., Montorsi F., Schulman C.C. Is erectile dysfunction the "tip of the iceberg" of a systemic vascular disorder? Eur. Urol. 44:2003;352-354
    • (2003) Eur. Urol. , vol.44 , pp. 352-354
    • Montorsi, P.1    Montorsi, F.2    Schulman, C.C.3
  • 64
    • 0036791014 scopus 로고    scopus 로고
    • Adenoviral gene transfer of endothelial nitric-oxide synthase (eNOS) partially restores normal pulmonary arterial pressure in eNOS-deficient mice
    • Champion H.C., Bivalacqua T.J., Greenberg S.S., Giles T.D., Hyman A.L., Kadowitz P.J. Adenoviral gene transfer of endothelial nitric-oxide synthase (eNOS) partially restores normal pulmonary arterial pressure in eNOS-deficient mice. Proc. Natl. Acad. Sci. USA. 99:2002;13248-13253
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 13248-13253
    • Champion, H.C.1    Bivalacqua, T.J.2    Greenberg, S.S.3    Giles, T.D.4    Hyman, A.L.5    Kadowitz, P.J.6
  • 65
    • 0033993756 scopus 로고    scopus 로고
    • In vivo gene transfer of prepro-calcitonin gene-related peptide to the lung attenuates chronic hypoxia-induced pulmonary hypertension in the mouse
    • Champion H.C., Bivalacqua T.J., Toyoda K., Heistad D.D., Hyman A.L., Kadowitz P.J. In vivo gene transfer of prepro-calcitonin gene-related peptide to the lung attenuates chronic hypoxia-induced pulmonary hypertension in the mouse. Circulation. 101:2000;923-930
    • (2000) Circulation , vol.101 , pp. 923-930
    • Champion, H.C.1    Bivalacqua, T.J.2    Toyoda, K.3    Heistad, D.D.4    Hyman, A.L.5    Kadowitz, P.J.6
  • 66
    • 0037107393 scopus 로고    scopus 로고
    • Role of calcitonin gene-related peptide (CGRP) in chronic hypoxia-induced pulmonary hypertension in the mouse. Influence of gene transfer in vivo
    • Bivalacqua T.J., Hyman A.L., Kadowitz P.J., Paolocci N., Kass D.A., Champion H.C. Role of calcitonin gene-related peptide (CGRP) in chronic hypoxia-induced pulmonary hypertension in the mouse. Influence of gene transfer in vivo. Regul. Pept. 108:2002;129-133
    • (2002) Regul. Pept. , vol.108 , pp. 129-133
    • Bivalacqua, T.J.1    Hyman, A.L.2    Kadowitz, P.J.3    Paolocci, N.4    Kass, D.A.5    Champion, H.C.6
  • 67
    • 0037152092 scopus 로고    scopus 로고
    • Sildenafil for treatment of lung fibrosis and pulmonary hypertension: A randomised controlled trial
    • Ghofrani H.A., Wiedemann R., Rose F., Schermuly R.T., Olschewski H., Weissmann N., et al. Sildenafil for treatment of lung fibrosis and pulmonary hypertension: a randomised controlled trial. Lancet. 360:2002;895-900
    • (2002) Lancet. , vol.360 , pp. 895-900
    • Ghofrani, H.A.1    Wiedemann, R.2    Rose, F.3    Schermuly, R.T.4    Olschewski, H.5    Weissmann, N.6
  • 68
    • 0037452133 scopus 로고    scopus 로고
    • Sildenafil for lung fibrosis and pulmonary hypertension
    • [Author reply 263].
    • Kleinsasser A, Loeckinger A. Sildenafil for lung fibrosis and pulmonary hypertension. Lancet 2003;361:262-3 [Author reply 263].
    • (2003) Lancet , vol.361 , pp. 262-263
    • Kleinsasser, A.1    Loeckinger, A.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.