In vivo gene transfer of prepro-calcitonin gene-related peptide to the lung attenuates chronic hypoxia-induced pulmonary hypertension in the mouse

Circulation

Volumn 101, Issue 8, 2000, Pages 923-930

  Champion, Hunter C ^a   Bivalacqua, Trinity J ^a   Toyoda, Kazunori ^b   Heistad, Donald D ^b   Hyman, Albert L ^a   Kadowitz, Philip J ^a  

^a TULANE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF IOWA   (United States)

Author keywords

Genes; Hypoxia; Molecular biology; Peptides; Pulmonary heart disease

Indexed keywords

ADRENOMEDULLIN; ANGIOTENSIN; CALCITONIN GENE RELATED PEPTIDE; CYCLIC AMP; ENDOTHELIN 1; PHOSPHODIESTERASE INHIBITOR; PROTEIN PRECURSOR; ROLIPRAM; VIRUS VECTOR; ZAPRINAST;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DNA TRANSFER; ENZYME INHIBITION; GENE THERAPY; HEART RIGHT VENTRICLE HYPERTROPHY; HISTOPATHOLOGY; HYPOXIA; LUNG ARTERY PRESSURE; LUNG VASCULAR RESISTANCE; MEAN ARTERIAL PRESSURE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PULMONARY HYPERTENSION; TISSUE LEVEL;

EID: 0033993756     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.101.8.923     Document Type: Article

References (27)

1. Shimosegawa T, Said SI. Pulmonary calcitonin gene-related peptide immunoreactivity: nerve-endocrine cell interrelationships. Am J Respir Cell Mol Biol. 1991;4:126-134.
2. Springall DR, Polak JM. Calcitonin gene-related peptide and pulmonary hypertension in experimental hypoxia. Anat Rec. 1993;236:96-104.
3. Stevens TP, McBride JT, Peake JL, Pinkerton KE, Stripp BR. Cell proliferation contributes to PNEC hyperplasia after acute airway injury. Am J Physiol. 1997;272:L486-L493.
4. Kusakabe T, Kawakami T, Powell FL, Ellisman MH, Sawada H, Takenaka T. Distribution of substance P and calcitonin gene-related peptide immunoreactive nerve fibers in the trachea of chronically hypoxic rats. Brain Res Bull. 1996;39:335-339.
5. DeWitt BJ, Cheng DY, Caminiti GN, Nossaman BD, Coy DH, Murphy WA, Kadowitz PJ. Comparison of responses to adrenomedullin and calcitonin gene-related peptide in the pulmonary vascular bed of the cat. Eur J Pharmacol. 1994;257:303-306.
6. Hyman AL, Hao Q, Tower A, Kadowitz PJ, Champion HC, Gumusel B, Lippton H. Novel catheterization technique for the in vivo measurement of pulmonary vascular responses in rats. Am J Physiol. 1998;274: H1218-H1229.
7. Montuenga LM, Springall D, Gaer J, Winter FJ, Zhao L, McBride JT, Gaylor KM, Barer G, Polak JM. CGRP-immunoreactive endocrine cell proliferation in normal and hypoxic rat lung studied by immunocytochemical detection of incorporation of 5′-bromodeoxyuridine. Cell Tissue Res. 1992;268:9-15.
8. McBride JT, Springall DR, Winter RJ, Polak JM. Quantitative immunocytochemistry shows calcitonin gene-related peptide-like immunoreactivity in lung neuroendocrine cells is increased by chronic hypoxia in the rat. Am J Respir Cell Mol Biol. 1990;3:587-593.
9. Mannan MM, Springall DR, Enard C, Moradoghli-Hafatvani A, Eddahibi S, Adnot S, Polak JM. Decreased endothelium-dependent pulmonary vasodilator effect of calcitonin gene-related peptide in hypoxic rats contrasts with increased binding sites. Eur Respir J. 1995;8:2029-2037.
10. Kwan YW, Wadsworth RM, Kane KA. Effects of neuropeptide Y and calcitonin gene-related peptide on sheep coronary artery rings under oxygenated, hypoxic and simulated myocardial ischaemic conditions. Br J Pharmacol. 1990;99:774-778.
11. Keith IM, Ekman R. Dynamic aspects of regulatory lung peptides in chronic hypoxic pulmonary hypertension. Exp Lung Res. 1992;18: 205-224.
12. Tjen ALS, Ekman R, Lippton H, Cary J, Keith I. CGRP and somatostatin modulate chronic hypoxic pulmonary hypertension. Am J Physiol. 1992; 263:H681-H690.
13. Heistad DD, Faraci FM. Gene therapy for cerebral vascular disease. Stroke. 1996;27:1688-1693.
14. Janssens SP, Bloch KD, Nong Z, Gerard RD, Zoldhelyi P, Collen D. Adenoviral-mediated transfer of the human endothelial nitric oxide synthase gene reduces acute hypoxic pulmonary vasoconstriction in rats. J Clin Invest. 1996;98:317-324.
15. Schachtner SK, Rome JJ, Hoyt RF Jr, Newman KD, Virmani R, Dichek DA. In vivo adenovirus-mediated gene transfer via the pulmonary artery of rat. Circ Res. 1995;76:701-709.
16. Champion HC, Bivalacqua TJ, D'Souza DM, Ortiz LA, Jeter JR, Toyoda K, Heistad DD, Hyman AL, Kadowitz PJ. Gene-transfer of endothelial nitric oxide synthase to the lung of the mouse in vivo: effect on agonist-induced and flow-mediated responses. Circ Res. 1999;84:1422-1432.
17. Tyler RC, Bullock C, Lapuz C, Gorman C, Hepler LK, Tudor RM, McMurtry IF, Rodman DM. Polycationic lipid-mediated gene transfer to the abnormal pulmonary circulation. Chest. 1997;1211:122S-123S.
18. Toyoda K, Ooboshi H, Chu Y, Fasbender A, Davidson BL, Welsh MJ, Heistad DD. Cationic polymer and lipids enhance adenovirus-mediated gene transfer to rabbit carotid artery. Stroke. 1998;29:2181-2188.
19. Tjen ALS, Ekman R, Osborn J, Keith I. Pulmonary vascular pressure effects by endothelin-1 in normoxia and chronic hypoxia: a longitudinal study. Am J Physiol. 1996;271:H2246-H2253.
20. Hales CA, Kradin RL, Brandstetter RD, Zhu YJ. Impairment of hypoxic pulmonary artery remodeling by heparin in mice. Am Rev Respir Dis. 1983;128:747-751.
21. Marshall I. Mechanism of vascular relaxation by the calcitonin gene-related peptide. Ann NY Acad Sci. 1992;657:204-215.
22. Champion HC, Santiago JA, Murphy WA, Coy DH, Kadowitz PJ. Adrenomedullin-(22-52) antagonizes vasodilator responses to CGRP but not adrenomedullin in the cat. Am J Physiol. 1997;272:R234-R242.
23. Han ZQ, Coppock HA, Smith DM, Van Noorden S, Makgoba MW, Nicholl CG, Legon S. The interaction of CGRP and adrenomedullin with a receptor expressed in the rat pulmonary vascular endothelium. J Mol Endocrinol. 1997;18:267-272.
24. + channels, Kv1.5 and Kv2.1 in hypoxic pulmonary vasoconstriction and control of resting membrane potential in rat pulmonary artery myocytes. J Clin Invest. 1998;101: 2319-2330.
25. + channels in pulmonary artery smooth muscle cells of patients with primary pulmonary hypertension. Circulation. 1998;98:1400-1406.
26. + channels in CGRP-induced dilatation of basilar artery in vivo. Am J Physiol. 1993;265:H581-H585.
27. Gaine SP, Rubin LJ. Primary pulmonary hypertension. Lancet. 1998;352: 719-725.