메뉴 건너뛰기




Volumn 15, Issue , 2003, Pages S33-S40

Frontiers in gene therapy for erectile dysfunction

Author keywords

Erectile dysfunction; Gene therapy; Penile erection

Indexed keywords

ADENOVIRUS VECTOR; ANTISENSE OLIGODEOXYNUCLEOTIDE; BRAIN DERIVED NEUROTROPHIC FACTOR; CALCITONIN GENE RELATED PEPTIDE; CYCLIC GMP; GROWTH FACTOR; GUANYLATE CYCLASE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PHOSPHODIESTERASE; PHOSPHODIESTERASE V; PLASMID VECTOR; POTASSIUM CHANNEL; RHO KINASE; SUPEROXIDE DISMUTASE; UNCLASSIFIED DRUG; VASCULOTROPIN;

EID: 0142246427     PISSN: 09559930     EISSN: 14765489     Source Type: Journal    
DOI: 10.1038/sj.ijir.3901070     Document Type: Article
Times cited : (21)

References (37)
  • 1
    • 0036884167 scopus 로고    scopus 로고
    • The use and analysis of microarray data
    • Butte A. The use and analysis of microarray data. Nat rev Drug Disc 2002; 1: 951-960.
    • (2002) Nat Rev Drug Disc , vol.1 , pp. 951-960
    • Butte, A.1
  • 2
    • 0036211824 scopus 로고    scopus 로고
    • Integrating cancer genomics and proteomics in the post-genome era
    • Hanash SM et al. Integrating cancer genomics and proteomics in the post-genome era. Proteomics 2002; 2: 69-75.
    • (2002) Proteomics , vol.2 , pp. 69-75
    • Hanash, S.M.1
  • 4
    • 0034328925 scopus 로고    scopus 로고
    • Gene therapy: Trials and tribulations
    • Somia N, Verma IM. Gene therapy: trials and tribulations. Nat Rev Genet 2000; 1: 91-99.
    • (2000) Nat Rev Genet , vol.1 , pp. 91-99
    • Somia, N.1    Verma, I.M.2
  • 5
    • 0035690084 scopus 로고    scopus 로고
    • A brief overview of the past, present, and future. Gene Therapy
    • Scollay R. A brief overview of the past, present, and future. Gene Therapy. Ann NY Acad Sci 2001; 953: 26-30.
    • (2001) Ann NY Acad Sci , vol.953 , pp. 26-30
    • Scollay, R.1
  • 6
    • 0034989793 scopus 로고    scopus 로고
    • A death in the laboratory: The politics of the Gelsinger aftermath
    • Carmen IH. A death in the laboratory: the politics of the Gelsinger aftermath. Mol Ther 2001; 3: 425-428.
    • (2001) Mol Ther , vol.3 , pp. 425-428
    • Carmen, I.H.1
  • 7
    • 0035941087 scopus 로고    scopus 로고
    • Gene therapy: Safer and virus-free
    • Ferber D. Gene therapy: safer and virus-free. Science 2001; 23: 1638-1642.
    • (2001) Science , vol.23 , pp. 1638-1642
    • Ferber, D.1
  • 8
    • 0034212434 scopus 로고    scopus 로고
    • US Gene therapy in crisis
    • Zallen DT. US Gene therapy in crisis. Trends Gene Ther 2000; 16: 272-275.
    • (2000) Trends Gene Ther , vol.16 , pp. 272-275
    • Zallen, D.T.1
  • 9
    • 0030978643 scopus 로고    scopus 로고
    • Cloning of rat and human inducible penile nitric oxide synthase. Application for gene therapy of erectile dysfunction
    • Garban H et al. Cloning of rat and human inducible penile nitric oxide synthase. Application for gene therapy of erectile dysfunction. Biol Reprod 1997; 56: 954-963.
    • (1997) Biol Reprod , vol.56 , pp. 954-963
    • Garban, H.1
  • 10
    • 0031827271 scopus 로고    scopus 로고
    • Intracorporal injection of hSlo cDNA in rats produces physiologically relevant alterations in penile function
    • Christ GJ et al. Intracorporal injection of hSlo cDNA in rats produces physiologically relevant alterations in penile function. Am JPhysiol 1998; 275: H600-H608.
    • (1998) Am Jphysiol , vol.275
    • Christ, G.J.1
  • 11
    • 0033613191 scopus 로고    scopus 로고
    • Gene transfer of endothelial nitric oxide synthase to the penis augments erectile responses in the aged rat
    • Champion HC et al. Gene transfer of endothelial nitric oxide synthase to the penis augments erectile responses in the aged rat. Proc Natl Acad Sci USA. 1999; 96: 11648-11652.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 11648-11652
    • Champion, H.C.1
  • 12
    • 0034522064 scopus 로고    scopus 로고
    • Adenoviral gene transfer of endothelial nitric oxide synthase (ENOS) to the penis improves age-related erectile dysfunction in the rat
    • Bivalacqua TJ et al. Adenoviral gene transfer of endothelial nitric oxide synthase (eNOS) to the penis improves age-related erectile dysfunction in the rat. Int J Impot Res 2000; 12: S8-S17.
    • (2000) Int J Impot Res , vol.12
    • Bivalacqua, T.J.1
  • 13
    • 0036728933 scopus 로고    scopus 로고
    • Gene therapy of erectile dysfunction in the rat with penile neuronal nitric oxide synthase
    • Magee TR et al. Gene therapy of erectile dysfunction in the rat with penile neuronal nitric oxide synthase. Biol Reprod 2002; 67: 20-28.
    • (2002) Biol Reprod , vol.67 , pp. 20-28
    • Magee, T.R.1
  • 14
    • 0035078843 scopus 로고    scopus 로고
    • Nitric oxide synthase gene therapy for erectile dysfunction: Comparison of plasmid adenovirus, and adenovirus-transduced myoblast vectors
    • Tirney S et al. Nitric oxide synthase gene therapy for erectile dysfunction: comparison of plasmid adenovirus, and adenovirus-transduced myoblast vectors. Mol Urol 2001; 5: 37-43.
    • (2001) Mol Urol , vol.5 , pp. 37-43
    • Tirney, S.1
  • 15
    • 0034762419 scopus 로고    scopus 로고
    • Gene transfer of prepro-calcitonin gene-related peptide restores erectile function in the aged rat
    • Bivalacqua TJ et al. Gene transfer of prepro-calcitonin gene-related peptide restores erectile function in the aged rat. Biol Reprod 2001; 65: 1371-1377.
    • (2001) Biol Reprod , vol.65 , pp. 1371-1377
    • Bivalacqua, T.J.1
  • 16
    • 0034980979 scopus 로고    scopus 로고
    • The effect of adeno-associated virus mediated brain derived neurotrophic factor in an animal model of neurogenic impotence
    • Bakirciogla ME et al. The effect of adeno-associated virus mediated brain derived neurotrophic factor in an animal model of neurogenic impotence. J Urol 2001; 165: 2103-2109.
    • (2001) J Urol , vol.165 , pp. 2103-2109
    • Bakirciogla, M.E.1
  • 17
    • 0036043738 scopus 로고    scopus 로고
    • The effects of antisense oligonucleotides on the cyclic nucleotide monophosphates in smooth muscle cells of human corpus cavernosum
    • Bai WJ et al. The effects of antisense oligonucleotides on the cyclic nucleotide monophosphates in smooth muscle cells of human corpus cavernosum. Zhounghua Nan Ke Xue 2002; 8: 88-91.
    • (2002) Zhounghua Nan Ke Xue , vol.8 , pp. 88-91
    • Bai, W.J.1
  • 18
    • 0036430608 scopus 로고    scopus 로고
    • Adeno-associated viral gene transfer of dominant negative RhoA enhances erectile function in rats
    • Chitaley K et al. Adeno-associated viral gene transfer of dominant negative RhoA enhances erectile function in rats. Biochem Biophys Res Comm 2002; 298: 427-432.
    • (2002) Biochem Biophys Res Comm , vol.298 , pp. 427-432
    • Chitaley, K.1
  • 19
    • 0142167275 scopus 로고    scopus 로고
    • Enhancement of physiologic erectile function with nitric oxide synthase gene therapy
    • Rehman J et al. Enhancement of physiologic erectile function with nitric oxide synthase gene therapy. J Urol 1997; 157 (Suppl.): 201.
    • (1997) J Urol , vol.157 , pp. 201
    • Rehman, J.1
  • 20
    • 0035014761 scopus 로고    scopus 로고
    • Physiological roles for K+ channels and gap junctions in urogenital smooth muscle: Implications for improved understanding of urogenital function, disease and therapy
    • + channels and gap junctions in urogenital smooth muscle: implications for improved understanding of urogenital function, disease and therapy. Curr Drug Targets 2001; 2: 1-20.
    • (2001) Curr Drug Targets , vol.2 , pp. 1-20
    • Karicheti, V.1    Christ, G.J.2
  • 21
    • 0036725094 scopus 로고    scopus 로고
    • K channels as molecular targets for the treatment of erectile dysfunction
    • Christ GJ. K channels as molecular targets for the treatment of erectile dysfunction. J Androl 2002; 23: S10-S19.
    • (2002) J Androl , vol.23
    • Christ, G.J.1
  • 22
    • 0036093105 scopus 로고    scopus 로고
    • K channels and human corporal smooth muscle cell tone: Further evidence for the physiological relevance of the Maxi-K channel subtype to the regulation of human corporal smooth muscle tone
    • Spektor M et al. K channels and human corporal smooth muscle cell tone: further evidence for the physiological relevance of the Maxi-K channel subtype to the regulation of human corporal smooth muscle tone in vitro. J Urol 2002; 167: 2628-2635.
    • (2002) Vitro. J Urol , vol.167 , pp. 2628-2635
    • Spektor, M.1
  • 23
    • 0034981758 scopus 로고    scopus 로고
    • Integrative erectile biology: The effects of age and disease on gap junctions and ion channels and their potential value to the treatment of erectile dysfunction
    • Melman A, Christ GJ. Integrative erectile biology: the effects of age and disease on gap junctions and ion channels and their potential value to the treatment of erectile dysfunction. Urol Clin North Am 2001; 28: 217-231.
    • (2001) Urol Clin North Am , vol.28 , pp. 217-231
    • Melman, A.1    Christ, G.J.2
  • 24
    • 0032493461 scopus 로고    scopus 로고
    • Neuronal innervation, intracellular signal transduction and intercellular coupling: A model for syncytial tissue responses in the steady state
    • Ramanan SV, Brink PR, Christ GJ. Neuronal innervation, intracellular signal transduction and intercellular coupling: a model for syncytial tissue responses in the steady state. J Theor Biol 1998; 193: 69-84.
    • (1998) J Theor Biol , vol.193 , pp. 69-84
    • Ramanan, S.V.1    Brink, P.R.2    Christ, G.J.3
  • 25
    • 0030938777 scopus 로고    scopus 로고
    • Diminished neurogenic-, but not pharmacologic-induced intracavernous pressure responses in the 3 month Streptozotocin (STZ)-diabetic rat
    • Rehman J et al. Diminished neurogenic-, but not pharmacologic-induced intracavernous pressure responses in the 3 month Streptozotocin (STZ)-diabetic rat. Am J Physiol 1997; 272: H1960-H1971.
    • (1997) Am J Physiol , vol.272
    • Rehman, J.1
  • 26
    • 0036237972 scopus 로고    scopus 로고
    • VEGF gene delivery for treatment of ischemic cardiovascular disease
    • Koransky ML, Robbins RC, Blau HM. VEGF gene delivery for treatment of ischemic cardiovascular disease. Trends Cardio-vascMed 2002; 12: 108-114.
    • (2002) Trends Cardio-Vascmed , vol.12 , pp. 108-114
    • Koransky, M.L.1    Robbins, R.C.2    Blau, H.M.3
  • 27
    • 0032726786 scopus 로고    scopus 로고
    • Future treatment for ED: Growth factors and gene therapy
    • Lue TF. Future treatment for ED: growth factors and gene therapy. Int J Impot Res 1999; 11: S56-S57.
    • (1999) Int J Impot Res , vol.11
    • Lue, T.F.1
  • 28
    • 0032919721 scopus 로고    scopus 로고
    • Expression of messenger ribonucleic acid splice variants for vascular endothelial growth factor in the penis of adult rats and humans
    • Burchardt M et al. Expression of messenger ribonucleic acid splice variants for vascular endothelial growth factor in the penis of adult rats and humans. Biol Reprod 1999; 60: 398-404.
    • (1999) Biol Reprod , vol.60 , pp. 398-404
    • Burchardt, M.1
  • 29
    • 0036142010 scopus 로고    scopus 로고
    • The effect of vascular endothelial growth factor on a rat model of traumatic arteriogenic erectile dysfunction
    • Lee Ming-Chan et al. The effect of vascular endothelial growth factor on a rat model of traumatic arteriogenic erectile dysfunction. J Urol 2002; 167: 761-767.
    • (2002) J Urol , vol.167 , pp. 761-767
    • Ming-Chan, L.1
  • 30
    • 0032721202 scopus 로고    scopus 로고
    • Endothelial cell transplantation into the corpus cavernosum: Moving towards cell-based gene therapy
    • Wessells H, Williams SK. Endothelial cell transplantation into the corpus cavernosum: moving towards cell-based gene therapy. J Urol 1999; 162: 2162-2164.
    • (1999) J Urol , vol.162 , pp. 2162-2164
    • Wessells, H.1    Williams, S.K.2
  • 31
    • 0034953090 scopus 로고    scopus 로고
    • Gene therapy strategies for urological dysfunction
    • Chancellor MB et al. Gene therapy strategies for urological dysfunction. Trends Mol Med 2001; 7: 301-306.
    • (2001) Trends Mol Med , vol.7 , pp. 301-306
    • Chancellor, M.B.1
  • 32
    • 0035110530 scopus 로고    scopus 로고
    • Potential application of gene therapy for the treatment of erectile dysfunction
    • Bivalacqua TJ, HeBstrom WJG. Potential application of gene therapy for the treatment of erectile dysfunction. J Androl 2001; 22: 183-190.
    • (2001) J Androl , vol.22 , pp. 183-190
    • Bivalacqua, T.J.1    Hebstrom, W.J.G.2
  • 33
    • 0033940411 scopus 로고    scopus 로고
    • Male sexual dysfunction-the new millennium
    • Donatucci CF. Male sexual dysfunction-the new millennium. Curr Opin Urol 2000; 10: 313-317.
    • (2000) Curr Opin Urol , vol.10 , pp. 313-317
    • Donatucci, C.F.1
  • 34
    • 0035553633 scopus 로고    scopus 로고
    • Gene therapy: Future therapy for erectile dysfunction
    • Schenk G, Melman A, Christ GJ. Gene therapy: future therapy for erectile dysfunction. Curr Urol Rep 2001; 2: 480-487.
    • (2001) Curr Urol Rep , vol.2 , pp. 480-487
    • Schenk, G.1    Melman, A.2    Christ, G.J.3
  • 35
    • 4243284870 scopus 로고    scopus 로고
    • Potentiation of erectile response with the combination of endothelial NOS gene therapy and sildenafil in streptozotocin diabetic rats
    • Bivalacqua TJ et al. Potentiation of erectile response with the combination of endothelial NOS gene therapy and sildenafil in streptozotocin diabetic rats. Int J Impot Res 2002; 14 (Suppl 3): S12.
    • (2002) Int J Impot Res , vol.14 , Issue.3
    • Bivalacqua, T.J.1
  • 36
    • 0036854060 scopus 로고    scopus 로고
    • Gene therapy for erectile dysfunction: Where is it going?
    • Christ GJ. Gene therapy for erectile dysfunction: where is it going? Curr Opin Urol 2002; 12: 497-501.
    • (2002) Curr Opin Urol , vol.12 , pp. 497-501
    • Christ, G.J.1
  • 37
    • 0037377580 scopus 로고    scopus 로고
    • Gene transfer of extracellular SOD to the penis reduces O2 and improves erectile function in aged rats
    • Bivalacqua TJ et al. Gene transfer of extracellular SOD to the penis reduces O2 and improves erectile function in aged rats. Am JPhysiol 2003; 284: H1408-H1421.
    • (2003) Am Jphysiol , vol.284
    • Bivalacqua, T.J.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.