The neuroprotective effects of Uncaria hirsute haviland on amyloid β protein-induced toxicity in rat cortical neurons

Chinese Pharmaceutical Journal

Volumn 55, Issue 5, 2003, Pages 319-334

  Wang, Chuen Neu ^a   Chen, I Ju ^a   Lin, Yun Lian ^a   Chi, Chih Wen ^b   Chen, Chieh Fu ^a   Shiao, Young Ji ^a  

^a NATIONAL RESEARCH INSTITUTE OF CHINESE MEDICINE   (Taiwan)

^b NATIONAL YANG MING UNIVERSITY   (Taiwan)

Author keywords

Amyloid protein; Neuroprotective effect; Uncaria hirsute Haviland

Indexed keywords

ACTIVATION ANALYSIS; CONDENSATION; DISEASES; PATHOLOGY; PATIENT TREATMENT; PROTEINS;

ALZHEIMER'S DISEASES; PATHOGENESIS;

DRUG PRODUCTS;

ACETIC ACID ETHYL ESTER; AMYLOID BETA PROTEIN; ANTIOXIDANT; CASPASE 2; CASPASE 3; CASPASE 8; CASPASE 9; CATECHIN; CYTOCHROME C; EPIGALLOCATECHIN; HERBACEOUS AGENT; PLANT EXTRACT; PROBUCOL; REACTIVE OXYGEN METABOLITE; UNCARIA HIRSUTE EXTRACT; UNCLASSIFIED DRUG; UNINDEXED DRUG; UR EA 16; UR EA 17; UR EA 18; UR EA 19; UR EA 8; UR EA A1; UR EA A2; UR EA A3; UR EA A4; UR EA A567; UR EA B10; UR EA B3; UR EA B8; UR EA B9;

ALZHEIMER DISEASE; ANIMAL CELL; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; BRAIN NERVE CELL; CELL ASSAY; CELL LEVEL; CELL VIABILITY; CHINESE MEDICINE; CHROMATIN CONDENSATION; COGNITIVE DEFECT; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOPATHOGENIC EFFECT; DRUG EFFECT; DRUG IDENTIFICATION; DRUG ISOLATION; DRUG MECHANISM; DRUG PURIFICATION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME INHIBITION; ENZYME MECHANISM; ENZYME RELEASE; MEDICINAL PLANT; NERVE CELL CULTURE; NEUROPROTECTION; NEUROTOXICITY; NEWBORN; NONHUMAN; OXIDATIVE STRESS; PROTEIN AGGREGATION; PROTEIN FUNCTION; RAT; UNCARIA; UNCARIA HIRSUTE; UNCARIA RHYNCHOPHYLLA;

EID: 3142552345     PISSN: 10161015     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (37)

1. Selkoe, D. J. Deciphering Alzheimer's Disease: The Amyloid Precursor Protein Yields New Clues. Science 1990, 248(4959), 1058-1060.
2. Smith, M. A. Alzheimer Disease. Int Rev Neurobiol. 1998, 42, 1-54.
3. Buxbaum, J. D.; Greengard, P. Regulation of APP Processing by Intra- and Intercellular Signals. Ann. N. Y. Acad. Sci. 1996, 777, 327-331.
4. Selkoe, D. J. Amyloid β-Protein and the Genetics of Alzheimer's Disease. J. Biol. Chem. 1996, 271(31), 18295-18298.
5. Iversen, L. L.; Mortishire-smith, R. J.; Pollack, S. J.; Shearman, M. S. The Toxicity in vitro of β-Amyloid Protein. Biochem. J. 1995, 311, 1-16.
6. Estus, S.; Tucker, H. M.; van Rooyen, C.; Wright, S.; Brigham, E. F.; Wogulis, M.; Rydel, R. E. Aggregated Amyloid-β Protein Induces Cortical Neuronal Apoptosis and Concomitant "Apoptotic" Pattern of Gene Induction. J. Neurosci. 1997, 17(20), 7736-7745.
7. Ferreira, A.; Lu, Q.; Orecchio, L.; Kosik, K. S. Selective Phosphorylation of Adult Tau Isoforms in Mature Hippocampal Neurons Exposed to Fibrillar Aβ. Mol. Cell Neurosci. 1997, 9(3), 220-234.
8. Mattson, M. P.; Partin, J.; Begley, J. G. Amyloid β-Peptide Induces Apoptosis-Related Events in Synapses and Dendrites. Brain Res. 1998, 807(1-2), 167-176.
9. Yankner, B. A. Mechanisms of Neuronal Degeneration in Alzheimer's Disease. Neuron 1996, 16(5), 921-32.
10. Loo, D. T.; Copani, A.; Pike, C. J.; Whittemore, E. R.; Walencewicz, A. J.; Cotman, C. W. Apoptosis Is Induced by β-Amyloid in Cultured Central Nervous System Neurons. Proc. Natl. Acad. Sci. U.S.A. 1993, 90(17), 7951-7955.
11. Maurice, T.; Lockhart, B. P.; Privat, A. Amnesia Induced in Mice by Centrally Administered β-Amyloid Peptides Involves Cholinergic Dysfunction. Brain Res. 1996, 706, 181-193.
12. Shiao, Y. J.; and Wang, C. N. Molecular Pathogenesis, Treatment Strategies and Animal Models of Alzheimer's Disease Chin. Pharmaceut. J. 2002, 54(1), 1-16.
13. 2+ Homeostasis and Cell Death. J Neurosci. 1995, 15(9), 6239-6249.
14. Ekinci, F. J.; Malik, K. U.; Shea, T. B. Activation of the L Voltage-Sensitive Calcium Channel by Mitogen-Activated Protein (MAP) Kinase Following Exposure of Neuronal Cells to β-Amyloid. MAP Kinase Mediates β-Amyloid-Induced Neurodegeneration. J. Biol. Chem. 1999, 274(42), 30322-30027.
15. 2+ Channel Activity by β-Amyloid-(1-40) in Rat Cortical Synaptosomes and Cultured. J. Biol. Chem. 2000, 275(7), 4713-4718.
16. Keller, J. N.; Kindy, M. S.; Holtsberg, F. W.; St Clair, D. K.; Yen, H. C.; Germeyer, A.; Steiner, S. M.; Bruce-Keller, A. J.; Hutchins, J. B.; Mattson, M. P. Mitochondrial Manganese Superoxide Dismutase Prevents Neural Apoptosis and Reduces Ischemic Brain Injury: Suppression of Peroxynitrite Production, Lipid Peroxidation, and Mitochondrial Dysfunction. J Neurosci. 1998, 18(2), 687-697.
17. Pike, C. J.; Ramezan-Arab, N.; Cotman, C. W. β-Amyloid Neurotoxicity in vitro: Evidence of Oxidative Stress but not Protection by Antioxidants. J. Neurochem. 1997, 69(4), 1601-1611.
18. Behl, C.; Davis, J. B.; Lesley, R.; Schubert, D. Hydrogen Peroxide Mediates Amyloid Beta Protein Toxicity. Cell 1994, 77(6), 817-827.
19. Mark, R. J.; Lovell, M. A.; Markesbery, W. R.; Uchida, K.; Mattson, M. P. A Role for 4-Hydroxynonenal, An Aldehydic Product of Lipid Peroxidation, in Disruption of Ion Homeostasis and Neuronal Death Induced by Amyloid β-Peptide. J. Neurochem. 1997, 68(1), 255-264.
20. Wang, C. N.; Chi, C. W.; Lin, Y. L.; Chen, C. F.; Shiao, Y. J. The Neuroprotective Effects of Phytoestrogens on Amyloid β Protein-Induced Toxicity Are Mediated by Abrogating the Activation of Caspase Cascade in Rat Cortical Neurons. J. Biol. Chem. 2001, 276(7), 5287-5295.
21. Harada, J.; Sugimoto, M. Activation of Caspase-3 in β-Amyloid- Induced Apoptosis of Cultured Rat Cortical Neurons. Brain Res. 1999, 842(2), 311-323.
22. Nakagawa, T.; Zhu, H.; Morishima, N.; Li, E.; Xu, J.; Yankner, B. A.; Yuan, J. Caspase-12 Mediates Endoplasmic-Reticulum-Specific Apoptosis and Cytotoxicity by Amyloid-β. Nature 2000, 403(6765), 98-103.
23. Troy, C. M.; Rabacchi, S. A.; Friedman, W. J.; Frappier, T. F.; Brown, K.; Shelanski, M. L. Caspase-2 Mediates Neuronal Cell Death Induced by β-Amyloid. J. Neurosci. 2000, 20(4), 1386-92.
24. Giovanni, A.; Keramaris, E.; Morris, E. J.; Hou, S. T.; O'Hare, M.; Dyson, N.; Robertson, G. S.; Slack, R. S.; Park, D. S. E2F1 Mediates Death of β-Amyloid-Treated Cortical Neurons in A Manner Independent of P53 and Dependent on Bax and Caspase 3. J. Biol. Chem. 2000, 275(16), 11553-11560.
25. Behl, C.; Davis, J.; Cole, G. M.; Schubert, D. Vitamin E Protects Nerve Cells from Amyloid β Protein Toxicity. Biochem. Biophys. Res. Commun. 1992, 186, 944-950.
26. Pappolla, M. A.; Sos, M.; Omar, R. A.; Bick, R. J.; Hickson-Bick, D. L.; Reiter, R. J.; Efthimiopoulos, S.; Robakis, N. K. Melatonin Prevents Death of Neuroblastoma Cells Exposed to the Alzheimer Amyloid Peptide. J. Neurosci. 1997, 17, 1683-1690.
27. 2+ Channels: A Possible Involvement of Free Radicals. J. Neurochem. 1997, 68, 265-271.
28. Prehn, J. H.; Bindokas, V. P.; Jordan, J.; Galindo, M. F.; Ghadge, G. D.; Roos, R. P.; Boise, L. H.; Thompson, C. B.; Krajewski, S.; Reed, J. C.; Miller, R. J. Protective Effect of Transforming Growth Factor-β 1 on β-Amyloid Neurotoxicity in Rat Hippocampal Neurons. Mol. Pharmacol. 1996, 49, 319-328.
29. Thushara, K. K.; Diyabalanage, B. M.; Mallika, K.; Wanniga, G. P.; Jayasinghe, L.; Merlini, L.; and Scagioni, L. Alkaloids of Uncaria Elliptica. Phytochemistry 1997, 45, 1731-1732.
30. Thushara, K. K.; Diyabalanage, G.; Wannigama, P.; Weerasuriya, A.; Jayasinghe, L.; and Simmonds, P. Ursene Carboxylic Acids of Uncaria Elliptica. Phytochemistry 1995, 40, 1311-1312.
31. Falkiewicz, B.; Lukasiak, J. Vilcacora [Uncaria tomentosa (Willd.) D. C. and Uncaria Guianensis (Aublet) Gimell.]-A Review of Published Scientific Literature. Case. Rep. Clin. Pract. Rev. 2001, 2, 305-316.
32. Brewer, G. J. Isolation and Culture of Adulat Rat Hippocampal Neurons. J. Neurosci. Meth. 1997, 71, 143-155.
33. Chan, G. C.; Hinds, T. R.; Impey, S.; and Storm, D. R. Hippocampal Neurotoxicity of Delta9-Tetrahydrocannabinol. J. Neurosci. 1998, 18, 5322-5332.
34. Wood, A. G.; Cribbs, D. H.; Whittemore, E. R.; Cotman, C. W. Heparan Sulfate and Chondroitin Sulfate Glycosaminoglycan Attenuate β-Amyloid(25- 35) induced Neurodegeneration in Cultured Hippocampal Neurons. Brain Res. 1995, 697, 53-62.
35. Kruman, I.; Bruce-Keller, A. J.; Bredesen, D.; Waeg, G.; and Mattson, M. P. Evidence that 4-Hydroxynonenal Mediates Oxidative Stress-induced Neuronal Apoptosis. J. Neurosci. 1997, 17, 5089-5100.
36. Pellegrini, N. R. R.; Yang, M.; and Rich-Evans, C. Screening of Dietary Carotenoids and Carotenoid-rich Fruit Extracts for Antioxidant Activities Applying [2,2′-Azinobis(3-Ethylenebehzothiazoline-6-Sulfonic Acid)] Radical Cation Decolorization Assay. Meth. Enzymol. 1999, 299, 379-389.
37. Ivins, K. J.; Thornton, P. L.; Rohn, T. T.; Cotman, C. W. Neuronal Apoptosis Induced by β-Amyloid is Mediated by Caspase-8. Neurobiol. Dis. 1999, 6, 440-449.