메뉴 건너뛰기




Volumn 15, Issue 6, 2005, Pages 1089-1096

Variable MLH1 promoter methylation patterns in endometrial carcinomas of endometrioid subtype lacking DNA mismatch repair

Author keywords

Bisulphite sequencing; Endometrial carcinomas; Methylation; Microsatellite instability; MLH1; Tumorigenesis

Indexed keywords

BISULFITE; PROTEIN MLH1;

EID: 30944450911     PISSN: 1048891X     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1525-1438.2005.00266.x     Document Type: Article
Times cited : (9)

References (32)
  • 2
    • 0029943449 scopus 로고    scopus 로고
    • Mismatch repair in replication fidelity, genetic recombination, and cancer biology
    • Modrich P, Lahue R. Mismatch repair in replication fidelity, genetic recombination, and cancer biology. Annu Rev Biochem 1996;65:101-33.
    • (1996) Annu Rev Biochem , vol.65 , pp. 101-133
    • Modrich, P.1    Lahue, R.2
  • 3
    • 0035161816 scopus 로고    scopus 로고
    • Functional interactions and signaling properties of mammalian DNA mismatch repair proteins
    • Bellacosa A. Functional interactions and signaling properties of mammalian DNA mismatch repair proteins. Cell Death Differ 2001;8:1076-92.
    • (2001) Cell Death Differ , vol.8 , pp. 1076-1092
    • Bellacosa, A.1
  • 4
    • 0027137935 scopus 로고
    • Hypermutability and mismatch repair deficiency in RER+ tumor cells
    • Parsons R, Li GM, Longley MJ et al. Hypermutability and mismatch repair deficiency in RER+ tumor cells. Cell 1993;75:1227-36.
    • (1993) Cell , vol.75 , pp. 1227-1236
    • Parsons, R.1    Li, G.M.2    Longley, M.J.3
  • 5
    • 10344228783 scopus 로고    scopus 로고
    • Altered expression of hMSH2 and hMLH1 in tumors with microsatellite instability and genetic alterations in mismatch repair genes
    • Thibodeau SN, French AJ, Roche PC et al. Altered expression of hMSH2 and hMLH1 in tumors with microsatellite instability and genetic alterations in mismatch repair genes. Cancer Res 1996;56:4836-40.
    • (1996) Cancer Res , vol.56 , pp. 4836-4840
    • Thibodeau, S.N.1    French, A.J.2    Roche, P.C.3
  • 6
    • 0032997736 scopus 로고    scopus 로고
    • MLH1 promoter methylation and gene silencing is the primary cause of microsatellite instability in sporadic endometrial cancers
    • Simpkins SB, Bocker T, Swisher EM et al. MLH1 promoter methylation and gene silencing is the primary cause of microsatellite instability in sporadic endometrial cancers. Hum Mol Genet 1999;8:661-6.
    • (1999) Hum Mol Genet , vol.8 , pp. 661-666
    • Simpkins, S.B.1    Bocker, T.2    Swisher, E.M.3
  • 7
    • 0028883556 scopus 로고
    • Mutations in DNA mismatch repair genes are not responsible for microsatellite instability in most sporadic endometrial carcinomas
    • Katabuchi H, van Rees B, Lambers AR et al. Mutations in DNA mismatch repair genes are not responsible for microsatellite instability in most sporadic endometrial carcinomas. Cancer Res 1995;55:5556-60.
    • (1995) Cancer Res , vol.55 , pp. 5556-5560
    • Katabuchi, H.1    Van Rees, B.2    Lambers, A.R.3
  • 8
    • 0029846318 scopus 로고    scopus 로고
    • Absence of mutations in DNA mismatch repair genes in sporadic endometrial tumors with microsatellite instability
    • Lim PC, Tester D, Cliby W et al. Absence of mutations in DNA mismatch repair genes in sporadic endometrial tumors with microsatellite instability. Clin Cancer Res 1996;2:1907-11.
    • (1996) Clin Cancer Res , vol.2 , pp. 1907-1911
    • Lim, P.C.1    Tester, D.2    Cliby, W.3
  • 9
    • 0345357773 scopus 로고    scopus 로고
    • Gene silencing in cancer in association with promoter hypermethylation
    • Herman JG, Baylin SB. Gene silencing in cancer in association with promoter hypermethylation. N Engl J Med 2003;349:2042-54.
    • (2003) N Engl J Med , vol.349 , pp. 2042-2054
    • Herman, J.G.1    Baylin, S.B.2
  • 10
    • 0033556428 scopus 로고    scopus 로고
    • Causes and consequences of microsatellite instability in endometrial carcinoma
    • Gurin CC, Federici MG, Kang L, Boyd J. Causes and consequences of microsatellite instability in endometrial carcinoma. Cancer Res 1999;59:462-6.
    • (1999) Cancer Res , vol.59 , pp. 462-466
    • Gurin, C.C.1    Federici, M.G.2    Kang, L.3    Boyd, J.4
  • 11
    • 0032487831 scopus 로고    scopus 로고
    • MLH1 promoter hypermethylation is associated with the microsatellite instability phenotype in sporadic endometrial carcinomas
    • Esteller M, Levine R, Baylin SB, Ellenson LH, Herman JG. MLH1 promoter hypermethylation is associated with the microsatellite instability phenotype in sporadic endometrial carcinomas. Oncogene 1998;17:2413-7.
    • (1998) Oncogene , vol.17 , pp. 2413-2417
    • Esteller, M.1    Levine, R.2    Baylin, S.B.3    Ellenson, L.H.4    Herman, J.G.5
  • 12
    • 0032706744 scopus 로고    scopus 로고
    • HMLH1 promoter hypermethylation is an early event in human endometrial tumorigenesis
    • Esteller M, Catasus L, Matias-Guiu X et al. hMLH1 promoter hypermethylation is an early event in human endometrial tumorigenesis. Am J Pathol 1999;155:1767-72.
    • (1999) Am J Pathol , vol.155 , pp. 1767-1772
    • Esteller, M.1    Catasus, L.2    Matias-Guiu, X.3
  • 13
    • 0033813298 scopus 로고    scopus 로고
    • Methylation of hMLH1 in a population-based series of endometrial carcinomas
    • Salvesen HB, MacDonald N, Ryan A et al. Methylation of hMLH1 in a population-based series of endometrial carcinomas. Clin Cancer Res 2000;6:3607-13.
    • (2000) Clin Cancer Res , vol.6 , pp. 3607-3613
    • Salvesen, H.B.1    MacDonald, N.2    Ryan, A.3
  • 14
    • 0031017268 scopus 로고    scopus 로고
    • Methylation of the hMLH1 promoter correlates with lack of expression of hMLH1 in sporadic colon tumors and mismatch repair-defective human tumor cell lines
    • Kane MF, Loda M, Gaida GM et al. Methylation of the hMLH1 promoter correlates with lack of expression of hMLH1 in sporadic colon tumors and mismatch repair-defective human tumor cell lines. Cancer Res 1997;57: 808-11.
    • (1997) Cancer Res , vol.57 , pp. 808-811
    • Kane, M.F.1    Loda, M.2    Gaida, G.M.3
  • 17
    • 0037434934 scopus 로고    scopus 로고
    • Multiple sites required for expression in 5′-flanking region of the hMLH1 gene
    • Arita M, Zhong X, Min Z, Hemmi H, Shimatake H. Multiple sites required for expression in 5′-flanking region of the hMLH1 gene. Gene 2003;306:57-65.
    • (2003) Gene , vol.306 , pp. 57-65
    • Arita, M.1    Zhong, X.2    Min, Z.3    Hemmi, H.4    Shimatake, H.5
  • 18
    • 0033599584 scopus 로고    scopus 로고
    • A core promoter and a frequent single-nucleotide polymorphism of the mismatch repair gene hMLH1
    • Ito E, Yanagisawa Y, Iwahashi Y et al. A core promoter and a frequent single-nucleotide polymorphism of the mismatch repair gene hMLH1. Biochem Biophys Res Commun 1999;256:488-94.
    • (1999) Biochem Biophys Res Commun , vol.256 , pp. 488-494
    • Ito, E.1    Yanagisawa, Y.2    Iwahashi, Y.3
  • 19
    • 0035913723 scopus 로고    scopus 로고
    • Transcriptional regulation of the mismatch repair gene hMLH1
    • Quaresima B, Faniello MC, Baudi F et al. Transcriptional regulation of the mismatch repair gene hMLH1. Gene 2001;275:261-5.
    • (2001) Gene , vol.275 , pp. 261-265
    • Quaresima, B.1    Faniello, M.C.2    Baudi, F.3
  • 20
    • 0033135049 scopus 로고    scopus 로고
    • Methylation of CpG in a small region of the hMLH1 promoter invariably correlates with the absence of gene expression
    • Deng G, Chen A, Hong J, Chae HS, Kim YS. Methylation of CpG in a small region of the hMLH1 promoter invariably correlates with the absence of gene expression. Cancer Res 1999;59:2029-33.
    • (1999) Cancer Res , vol.59 , pp. 2029-2033
    • Deng, G.1    Chen, A.2    Hong, J.3    Chae, H.S.4    Kim, Y.S.5
  • 21
    • 0036311084 scopus 로고    scopus 로고
    • Microsatellite instability, MLH1 promoter methylation, and loss of mismatch repair in endometrial cancer and concomitant atypical hyperplasia
    • Horowitz N, Pinto K, Mutch DG et al. Microsatellite instability, MLH1 promoter methylation, and loss of mismatch repair in endometrial cancer and concomitant atypical hyperplasia. Gynecol Oncol 2002;86:62-8.
    • (2002) Gynecol Oncol , vol.86 , pp. 62-68
    • Horowitz, N.1    Pinto, K.2    Mutch, D.G.3
  • 22
    • 0036102571 scopus 로고    scopus 로고
    • MSI in endometrial carcinoma: Absence of MLH1 promoter methylation is associated with increased familial risk for cancers
    • Whelan AJ, Babb S, Mutch DG et al. MSI in endometrial carcinoma: absence of MLH1 promoter methylation is associated with increased familial risk for cancers. Int J Cancer 2002;99:697-704.
    • (2002) Int J Cancer , vol.99 , pp. 697-704
    • Whelan, A.J.1    Babb, S.2    Mutch, D.G.3
  • 23
    • 0141563684 scopus 로고    scopus 로고
    • High-resolution methylation analysis of the hMLH1 promoter in sporadic endometrial and colorectal carcinomas
    • Strazzullo M, Cossu A, Baldinu P et al. High-resolution methylation analysis of the hMLH1 promoter in sporadic endometrial and colorectal carcinomas. Cancer 2003;98:1540-6.
    • (2003) Cancer , vol.98 , pp. 1540-1546
    • Strazzullo, M.1    Cossu, A.2    Baldinu, P.3
  • 24
    • 0038670783 scopus 로고    scopus 로고
    • Frequent hypermethylation of MLH1 promoter in normal endometrium of patients with endometrial cancers
    • Kanaya T, Kyo S, Maida Y et al. Frequent hypermethylation of MLH1 promoter in normal endometrium of patients with endometrial cancers. Oncogene 2003;22: 2352-60.
    • (2003) Oncogene , vol.22 , pp. 2352-2360
    • Kanaya, T.1    Kyo, S.2    Maida, Y.3
  • 26
    • 0031015728 scopus 로고    scopus 로고
    • BAT-26, an indicator of the replication error phenotype in colorectal cancers and cell lines
    • Hoang JM, Cottu PH, Thuille B, Salmon RJ, Thomas G, Hamelin R. BAT-26, an indicator of the replication error phenotype in colorectal cancers and cell lines. Cancer Res 1997;57:300-3.
    • (1997) Cancer Res , vol.57 , pp. 300-303
    • Hoang, J.M.1    Cottu, P.H.2    Thuille, B.3    Salmon, R.J.4    Thomas, G.5    Hamelin, R.6
  • 27
    • 0034495161 scopus 로고    scopus 로고
    • Genetic and epigenetic modification of MLH1
    • Perucho M. Genetic and epigenetic modification of MLH1. Am J Pathol 2000;157:1052-3.
    • (2000) Am J Pathol , vol.157 , pp. 1052-1053
    • Perucho, M.1
  • 28
    • 13144266670 scopus 로고    scopus 로고
    • Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma
    • Herman JG, Umar A, Polyak K et al. Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma. Proc Natl Acad Sci U S A 1998;95:6870-5.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 6870-6875
    • Herman, J.G.1    Umar, A.2    Polyak, K.3
  • 29
    • 0035808312 scopus 로고    scopus 로고
    • Evidence that silencing of the HPRT promoter by DNA methylation is mediated by critical CpG sites
    • Chen C, Yang MC, Yang TP. Evidence that silencing of the HPRT promoter by DNA methylation is mediated by critical CpG sites. J Biol Chem 2001;276:320-8.
    • (2001) J Biol Chem , vol.276 , pp. 320-328
    • Chen, C.1    Yang, M.C.2    Yang, T.P.3
  • 30
    • 0027535235 scopus 로고
    • Effects of DNA methylation on DNA-binding proteins and gene expression
    • Tate PH, Bird AP. Effects of DNA methylation on DNA-binding proteins and gene expression. Curr Opin Genet Dev 1993;3:226-31.
    • (1993) Curr Opin Genet Dev , vol.3 , pp. 226-231
    • Tate, P.H.1    Bird, A.P.2
  • 31
    • 0342437491 scopus 로고    scopus 로고
    • MeCP2 is a transcriptional repressor with abundant binding sites in genomic chromatin
    • Nan X, Campoy FJ, Bird A. MeCP2 is a transcriptional repressor with abundant binding sites in genomic chromatin. Cell 1997;88:471-81.
    • (1997) Cell , vol.88 , pp. 471-481
    • Nan, X.1    Campoy, F.J.2    Bird, A.3
  • 32
    • 0642316935 scopus 로고    scopus 로고
    • Global DNA methylation in relation to hMLH1 and hMSH2 protein immunoreactivity in sporadic human endometrial carcinomas
    • Miturski R, Postawski K, Semczuk A et al. Global DNA methylation in relation to hMLH1 and hMSH2 protein immunoreactivity in sporadic human endometrial carcinomas. Int J Mol Med 2003;11:569-74.
    • (2003) Int J Mol Med , vol.11 , pp. 569-574
    • Miturski, R.1    Postawski, K.2    Semczuk, A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.