5-Fluorouracil-loaded microspheres prepared by spray-drying poly(D,L-lactide) and poly(lactide-co-glycolide) polymers: Characterization and drug release

Journal of Microencapsulation

Volumn 22, Issue 6, 2005, Pages 671-682

  Blanco, M D ^a   Sastre, R L ^a   Teijon C ^a   Olmo, R ^a   Teijon J M ^a  

^a UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

Author keywords

5 Fluorouracil; Controlled release; Microspheres; poly(D,L lactide); Poly(lactide co glycolide); Spray dryer

Indexed keywords

ANTINEOPLASTIC AGENT; FLUOROURACIL; MICROSPHERE; POLYGLACTIN; POLYLACTIDE; POLYMER;

ARTICLE; CONTROLLED RELEASE FORMULATION; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG RELEASE; MICROENCAPSULATION; PHARMACEUTICAL ENGINEERING; POROSITY; SPRAY DRYING;

ANTIMETABOLITES, ANTINEOPLASTIC; DELAYED-ACTION PREPARATIONS; DRUG DELIVERY SYSTEMS; DRUG STABILITY; FLUOROURACIL; MICROSCOPY, ELECTRON, SCANNING; MICROSPHERES; MOLECULAR WEIGHT; PARTICLE SIZE; POLYESTERS; POLYGLACTIN 910; TEMPERATURE;

EID: 30844456231     PISSN: 02652048     EISSN: 14645246     Source Type: Journal    
DOI: 10.1080/02652040500161990     Document Type: Article

References (44)

1. Anderson, JM, Shive, MS. Biodegradation and biocompatibility of PLA and PLGA microspheres Advanced Drug Delivery Reviews, 1997; 28:5-24
2. Bain, DF, Munday, DL, Smith, A. Modulation of rifampicin release from spray-dried microspheres using combinations of poly-(DL-lactide) Journal of Microencapsulation, 1999a; 16:369-385
3. Bain, DF, Munday, DL, Smith, A. Solvent influence on spray-dried biodegradable microspheres Journal of Microencapsulation, 1999b; 16:453-474
4. Benoit, JP, Faisant, N, Venier-Julienne, MC, Menei, P. Development of microspheres for neurological disorders: From basics to clinical applications Journal of Controlled Release, 2000; 65:285-296
5. Benoit, MA, Baras, B, Gillard, J. Preparation and characterization of protein-loaded poly(ε-caprolactone) microparticles for oral vaccine delivery International Journal of Pharmaceutics, 1999; 184:73-84
6. Blanco, MD, García, O, Gómez, C, Sastre, RL, Teijón, JM. In vivo drug delivery of 5-fluorouracil using poly(2-hydroxyethyl methacrylate-co-acrylamide) hydrogels Journal of Pharmaceutics & Pharmacology, 2000; 52:1319-1325
7. Blanco, MD, García, O, Trigo, RM, Teijón, JM, Katime, I. 5-Fluorouracil release from copolymeric hydrogels of itaconic acid monoester I. Acrylamide-co-monomethyl itaconate. Biomaterials, 1996; 17:1061-1067
8. Blanco-Príeto, MJ, Besseghir, K, Orsolini, P, Heimgartner, F, Deuschel, C, Merkle, HP, Nam-Trân, H, Gander, B. Importance of the test medium for the release kinetics of a somatostatin analogue from poly(D,L-lactide-co-glycolide) microspheres International Journal of Pharmaceutics, 1999; 184:243-250
9. Bouhadir, KH, Alsberg, E, Mooney, DJ. Hydrogels for combination delivery of antineoplastic agents Biomaterials, 2001; 22:2625-2633
10. Buckpitt, AR, Boyd, MR. A sensitive method for determination of 5-fluorouracil and 5-fluoro-2′-deoxyuridine in human plasma by high-pressure liquid chromatography Analytical Biochemistry, 1980; 106:432-437
11. Cadee, JA, Brouwer, LA, den Otter, W, Hennink, WE, van Luyn, MJA. A comparative biocompatibility study of micropheres based on crosslinked dextran or poly(lactic-co-glycolic)acid after subcutaneous injection in rats Journal of Biomedical Materials Research, 2001; 56:600-609
12. Denizli, A, Kiremitci, M, Piskin, E. Subcutaneous polymeric matrix system poly(HEMA-BGA) for controlled release of an anticancer drug (5-fluorouracil): I Synthesis and structure. Biomaterials, 1988a; 9:257-262
13. Denizli, A, Kiremitci, M, Piskin, E. Subcutaneous polymeric matrix system p(HEMA-BGA) for controlled release of an anticancer drug (5-fluorouracil): II Release kinetics. Biomaterials, 1988b; 9:363-366
14. Dickson, JLB, Cunningham, D. Systemic treatment of gastric cancer European Journal of Gastroenterology & Hepatology, 2004; 16:255-263
15. Dolinsky, A. High-temperature spray drying Drying Technology, 2001; 19:785-807
16. Dunne, M, Corrigan, OI, Ramtoola, Z. Influence of particle size and dissolution conditions on the degradation properties of polylactide-co-glycolide particles Biomaterials, 2000; 21:1659-1668
17. Earl, H, Iddawela, M. Epirubicin as adjuvant therapy in breast cancer Expert Reviews in Anticancer Therapy, 2004; 4:189-195
18. Freiberg, S, Zhu, X. Polymer microspheres for controlled drug release International Journal of Pharmaceutics, 2004; 282:1-18
19. Fu, YJ, Mi, FL, Wong, TB, Shyu, SS. Characteristics and controlled release of anticancer drug loaded poly(D,L-lactide) microparticles prepared by spray drying technique Journal of Microencapsulation, 2001; 18:733-747
20. Fung, LK, Saltzman, WM. Polymeric implants for cancer chemotherapy Advanced Drug Delivery Reviews, 1997; 26:209-230
21. García, O, Blanco, MD, Martín, JA, Teijón, JM. 5-Fluorouracil trapping in poly(2-hydroxyethyl methacrylate-co-acrylamide) hydrogels: In vitro drug delivery studies European Polymer Journal, 2000; 36:111-122
22. Goldberg, RM. Current approaches to first-line treatment of advanced colorectal cancer Clinical Colorectal Cancer, 2004; 4:S9-S15
23. Gómez, C, Blanco, MD, Bernardo, MV, Olmo, R, Muñíz, E, Teijón, JM. Cytarabine release from comatrices of albumin microspheres in a poly(lactide-co-glycolide) film: In vitro and in vivo studies European Journal of Pharmaceutics & Biopharmaceutics, 2004; 57:225-233
24. Gutman, RL, Peacock, G, Lu, DR. Targeted drug delivery for brain cancer treatment Journal of Controlled Release, 2000; 65:31-41
25. Jeyanthi, R, Nagarajan, B, Rao, KP. Solid tumour chemotherapy using implantable collagen-poly (HEMA) hydrogel containing 5-fluorouracil Journal of Pharmaceutics & Pharmacology, 1991; 43:60-62
26. Jones, E. Methylene chloride, an overview of human and enviromental effects Pharmaceutical Technology in Europe, 1996; 8:30-32
27. Jorizzo, J. Topical treatment of actinic keratosis with fluorouracil: Is irritation associated with efficacy? Journal of Drugs in Dermatology, 2004; 3:21-26
28. Kim, ES, Glisson, BS. Treatment of metastatic head and neck cancer: Chemotherapy and novel agents Cancer Treatment Research, 2003; 114:295-314
29. Lamprecht, A, Yamamoto, H, Takeuchi, H, Kawashima, Y. Microsphere design for the colonic delivery of 5-fluorouracil Journal of Controlled Release, 2003; 90:313-322
30. Lee, JS, Chae, GS, Kim, MS, Cho, SH, Lee, HB, Khang, G. Degradation behaviour in vitro for poly(D,L-lactide-co-glycolide) as drug carrier Bio-Medical Materials Engineering, 2004; 14:185-192
31. Longley, DB, Harkin, DP, Johnston, PG. 5-fluorouracil: Mechanisms of action and clinical strategies Nature Reviews in Cancer, 2003; 3:330-338
32. Lúck, M, Pistel, KF, Li, YX, Blunk, T, Múller, RH, Kissel, T. Plasma protein adsorption on biodegradable microspheres consisting of poly(D,L-lactide-co-glycolide), poly(l-lactide) or ABA triblock copolymers containing poly(oxyethylene) Influence of production method and polymer composition. Journal of Controlled Release, 1998; 55:107-120
33. Murillo, M, Gamazo, C, Goñi, MM, Irache, JM, Blanco-Príeto, MJ. Development of microparticles prepared by spray-drying as a vaccine delivery system against brucellosis International Journal of Pharmaceutics, 2002; 24:341-344
34. Pasetto, LM, Jirillo, A, Stefani, M, Monfardini, S. Old and new drugs in systemic therapy of pancreatic cancer Critical Reviews in Oncology & Hematology, 2004; 49:135-151
35. Rothenberg, ML. Current status of second-line therapy for metastatic colorectal cancer Clinical Colorectal Cancer, 2004; 4:S16-S21
36. Roullin, VG, Lemaire, L, Venier-Julienne, MC, Faisant, N, Franconi, F, Benoit, JP. Release kinetics of 5-fluorouracil-loaded microspheres on an experimental rat glioma Anticancer Research, 2003; 23:21-25
37. Schimmel, KJM, Richel, DJ, van den Brink, RBA, Guchelaar, HJ. Cardiotoxicity of cytotoxic drugs Cancer Treatment Reviews, 2004; 30:181-191
38. Shi, GX, Cai, Q, Wang, CY, Lu, N, Wang, SG, Bei, JZ. Fabrication and biocompatibility of cell scaffolds of poly(l-lactic acid) and poly(l-lactic-co-glycolic acid) Polymer Advanced Technology, 2002; 13: 227-232
39. Siepmann, J, Faisant, N, Akiki, J, Richard, J, Benoit, JP. Effect of the size of biodegradable microparticles on drug release: Experiment and theory Journal of Controlled Release, 2004; 96:123-134
40. Sinha, VR, Mittal, BR, Bhutani, KK, Kumria, R. Colonic drug delivery of 5-fluorouracil: An in vitro evaluation International Journal of Pharmaceutics, 2004; 269:101-108
41. Tutrone, WD, Saini, R, Caglar, S, Weinberg, JM, Crespo, J. Topical therapy for actinic keratoses, I: 5-Fluorouracil and imiquimod Cutis; Cutaneous Medicine For The Practitioner, 2003; 71:365-370
42. Wang, FJ, Wang, CH. Etanidazole-loaded microspheres fabricated by spray-drying different poly(lactide/glycolide) polymers: Effects on microsphere properties Journal of Biomaterials Science, Polymer Edition, 2003; 14:157-183
43. Yoshino, T, Machida, Y, Onishi, H, Nagai, T. Preparation and characterization of chitosan microspheres containing doxifluridine Drug Developments in Industrial Pharmacy, 2003; 29:417-427
44. Zhu, KJ, Zhang, JX, Wang, C, Yasuda, H, Ichimaru, A, Yamamoto, K. Preparation and in vitro release behaviour of 5-fluorouracil-loaded microspheres based on poly (L-lactide) and its carbonate copolymers Journal of Microencapsulation, 2003; 20:731-743