Characteristic and controlled release of anticancer drug loaded poly (D,L-lactide) microparticles prepared by spray drying technique

Journal of Microencapsulation

Volumn 18, Issue 6, 2001, Pages 733-747

  Fu, Y J ^a   Mi, F L ^a   Wong, T B ^a   Shyu, S S ^a  

^a NATIONAL CENTRAL UNIVERSITY   (Taiwan)

Author keywords

Anticancer drug; Controlled release; In vitro release; Microparticles; Poly(D,L lactide); Process parameters; Spray drying process

Indexed keywords

ANTINEOPLASTIC AGENT; CHLORAMBUCIL; MICROSPHERE; NANOPARTICLE; POLYLACTIC ACID; POLYLACTIDE; POLYMER;

AEROSOL; AIRFLOW; ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED RELEASE FORMULATION; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG SOLUBILITY; IN VITRO STUDY; PARAMETER; PARTICLE SIZE; SCANNING ELECTRON MICROSCOPY; TECHNIQUE; TEMPERATURE;

ANTINEOPLASTIC AGENTS; CAPSULES; CHLORAMBUCIL; DELAYED-ACTION PREPARATIONS; DRUG COMPOUNDING; DRUG STABILITY; HUMANS; MICROSCOPY, ELECTRON, SCANNING; PARTICLE SIZE; POLYESTERS;

EID: 0034776156     PISSN: 02652048     EISSN: None     Source Type: Journal    
DOI: 10.1080/02652040010055649     Document Type: Article

References (15)

1. Pharmacokinetics of oral methotrexate in children
2. Biodegradable implant systems for long term drug delivery using poly(lactic-co-glycolic) acid copolymers
3. Spray dried polylactide microsphere preparation: Influence of the technological parameters
4. Determination of the physical state of drug in microcapsule and microsphere formulations
5. Quality improvement of spray-drying, protein-loaded D,L-PLA microspheres by appropriate polymer solvent selection
6. Theoretical analysis of rate of release of solid drugs dispersion in solid matrices
7. The influence of biodegradable microcapsule formulation on the controlled release of a protein
8. Chitosan microspheres: Modification of polymeric chemphysical properties of spray-dried microspheres to control the release of antibiotic drug
9. Solvent evaporation, solvent extraction and spray drying for polylactide microsphere preparation
10. Preparation and characterization of copoly (DL-lactic/glycolic acid) microparticles for sustained release of thyrotropin releasing hormone by double nozzle spray drying method
11. Preparation of enteric-coated microcapsules for tableting by spray-drying technique and in vitro simulation of drug release from the tablet in GI tract
12. Present and future of PLA polymers
13. Preparation of coated particles using a spray drying process with an aqueous system
14. Lactide/glycolide polymers used as surgical suture material, raw material for osteosynthesis and in sustained release forms of drugs