Cloning and characterization of angiotensin converting enzyme related dipeptidylcarboxypeptidase from Leishmania donovani

Molecular and Biochemical Parasitology

Volumn 145, Issue 2, 2006, Pages 147-157

  Goyal, Neena ^a   Duncan, Robert ^b   Selvapandiyan, Angamuthu ^b   Debrabant, Alain ^b   Baig, Mirza S ^a   Nakhasi, Hira L ^b  

^a CENTRAL DRUG RESEARCH INSTITUTE   (India)

^b CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

Author keywords

Dipeptidylcarboxypeptidase; Drug target; Exopeptidases; Kala azar; Leishmania donovani

Indexed keywords

ALANINE; ANGIOTENSIN I; CAPTOPRIL; DIPEPTIDYL CARBOXYPEPTIDASE; GLUTAMIC ACID; HISTIDINE; HYPERTENSIVE AGENT;

AMASTIGOTE; ARTICLE; BINDING SITE; CONTROLLED STUDY; DNA MICROARRAY; DRUG TARGETING; ENZYME ACTIVITY; ENZYME ANALYSIS; ESCHERICHIA COLI; IMMUNOFLUORESCENCE; KINETOPLAST; LEISHMANIA DONOVANI; LIFE CYCLE; MOLECULAR CLONING; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMASTIGOTE; PROTEIN EXPRESSION;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMALS; BINDING SITES; CAPTOPRIL; CARRIER PROTEINS; CLONING, MOLECULAR; CYTOSOL; DNA, PROTOZOAN; ENDOPEPTIDASES; ENZYME INHIBITORS; ESCHERICHIA COLI; GENE EXPRESSION REGULATION, DEVELOPMENTAL; IMMUNOHISTOCHEMISTRY; LEISHMANIA DONOVANI; MOLECULAR SEQUENCE DATA; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PEPTIDYL-DIPEPTIDASE A; RECOMBINANT PROTEINS; SEQUENCE ANALYSIS, DNA; SEQUENCE HOMOLOGY, AMINO ACID;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; LEISHMANIA DONOVANI; MAMMALIA; NASO HEXACANTHUS; PROTOZOA;

EID: 30544442263     PISSN: 01666851     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molbiopara.2005.09.014     Document Type: Article

References (54)

1. E. Handman Leishmaniasis current status of vaccine development Clin Microbiol Rev 14 2001 229 243
2. P. Desjeux Human Leishmniasis: epidemiology and public health aspects World Health Stat Quart 45 1992 267 275
3. D. Molyneux, and R. Killick-Kendrick Morphology, ultrastructure and lifecycles W. Peters R. Killick-Kendrick The leishmaniasis in biology and Medicine vol. 1 1987 Academic Press 121 176
4. J. Alexander, and D.G. Russel The interaction of Leishamania species with macrophages Adv Parasitol 32 1992 175 254
5. D. Zilberstein, and M. Shapira The role of pH and temperature on the development of Leishmania parasites Annu Rev Microbiol 48 1994 449 470
6. S. Garlapati, E. Dahan, and M. Shapira Effect of acidic pH on heat shock gene expression in Leishmania Mol Biochem Parasitol 100 1999 95 101
7. W.W. Zang, and G. Matlashewski Loss of virulence in Leishmania donovani deficient in an amastigote specific protein A2 Proc Natl Acad Sci USA 94 1997 8807 8811
8. F.Y. Wu El, D. Sereno, S. Tamar, and B. Papadopulou A new developmentally regulated gene family in Leishmania amastigotes encoding a homology of amastin surface protein Mol Biochem Parasitol 110 2000 345 357
9. M. Wiesgigl, and J. Clos Heat shock Protein 90 homeostatic controls stage differentiation in Leishmania donovani Mol Biol Cell 12 2001 3307 3316
10. A. Selvapandiyan, A. Debrabant, and R. Duncan Centrin gene disruption impairs stage specific basal body duplication and cell cycle progression in Leishmania J Biol Chem 279 2004 25703 25710
11. F.J. Rosenthal Proteases of protozoan parasites Adv Parasitol 43 1999 105 159
12. J.C. Mottram, G.H. Coombs, and J. Alexander Cysteine peptidase as virulence factors of Leishmania Curr Opin Microbiol 7 2004 375 381
13. J. Bouvier, P. Schneider, and R. Etges Leishmanolysin: surface metalloproteinase of Leishmania Meth Enzymol 248 1995 614 633
14. A.S. Andrade Ribeirode, M.M. Santero, M.N. de Melo, and M. Mares-Guia Leishmania (Leishmania) amazonensis: purification and enzymatic characterization of soluble serine oligopeptidase Exp Parasitol 89 1998 153 160
15. R.E. Morty, and J. Morehead Cloning and characterization of leucylaminopeptidase from three pathogenic Leishmania species J Biol Chem 277 2002 26057 26065
16. P. Schneider, and T.A. Glaser Characterization of two soluble metalloprotease in protozoan parasite Leishmania major Mol Biochem Parasitol 62 1993 223 231
17. C.D. Robertson, and G.H. Coombs Cathepsin B like cysteine protease of Leishmania mexicana Mol Biochem Parasitol 62 1993 271 279
18. G. Bart, M.J. Frame, R. Carter, G.H. Coombs, and J.C. Mottram Cathepsin B like cysteine proteinase deficient mutants of Leishmania mexicana Mol Biochem Parasitol 88 1997 53 61
19. W.A.S. Judice, L. Puzer, and S.S. Cortin Carboxy dipeptidase activities of recombinant cysteine peptidase cruzain of Trypanosoma cruzi and CPB of Leishmania mexicana Eur J Biochem 271 2004 1046 1053
20. A. Yaron, D. Mlynar, and A. Berger A dipeptidylcarboxypeptidase from Escherichia coli Biochem Biophys Res Commun 47 1972 897 902
21. L.T. Skeggs, J.R. Kahn, and N.P. Shumway The purification of hypertension II J Exp Med 103 1956 301 307
22. R.L. Soffer Angiotensin converting enzyme and the regulation of vasoactive peptides Annu Rev Biochem 45 1976 73 94
23. C.E. Deutch, and R.L. Soffer Escherichia coli mutant defective in dipeptidyl carboxypeptidase Pro Natl Acad Sci USA 75 1978 5998 6001
24. A. Debrabant, M. Gottilieb, and D.M. Dwyer Isolation and characterization of gene encoding the surface membrane 3′-nucleotidase/nuclease of Leishmania donovani Mol Biochem Parasitol 71 1995 51 63
25. A. Debrabant, M.B. Joshi, P.F. Pimenta, and D.M. Dwyer Generation of Leishmania amastigotes, their growth and biological characteristics Int J Parasitol 34 2004 205 217
26. N.S. Akyopyants, S.W. Clifton, and J. Martin A survey of Leishmania major Friedlin strain VI genome by short gun sequencing: a resource of DNA microarray and expression profiling Mol Biochem Parasitol 113 2001 337 340
27. R. Duncan, P. Salotra, N. Goyal, N. Akyopyants, M.B. Stephen, and H.L. Nakhasi The application of gene expression microarray technology to kinetoplastid pathogenesis Curr Mol Med 4 2004 611 621
28. K. Wilson, S. Hanson, S. Landfear, and B. Ulman Nucleotide sequence of Leishmania donovani medRNA gene Nucl Acid Res 19 1991 5787
29. J. Sambrook, E.F. Fritsch, and T. Maniatis Molecular cloning: a laboratory manual 2nd ed. 1989 Cold Spring Harbor LABORATORY Cold Spring Harbor, NY
30. U.K. Lammeli Cleavage of structrural proteins during the assembly of the head of bacteriphage T4 Nature 227 1970 678 685
31. H. Towbin, T. Staehelin, and B. Falgout Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some application Proc Natl Acad Sci USA 76 1979 4350 4354
32. R. Tondon, M.P. Singh, W. Haq, M. Dikshit, G.K. Patnaik, and M.M. Dhar Synthesis of novel tetrapeptides as potential ACE inhibitors Ind J Chem 36B 1997 386 390
33. A. Padilla, R. Noiva, N. Lee, K.V. Krishna Mohan, H.L. Nakhasi, and A. Debrabant An atypical protein disulfide isomerase from protozoan parasite Leishmania containing a single thirodoxin like domain J Biol Chem 278 2003 1872 1878
34. D.W. Cushman, and H.S. Cheung Spectrophotometric assay for angiotensin converting enzyme Biochem Pharmacol 20 1971 1637 1648
35. B. Holmquist, P. Burnning, and J.F. Riordan A continous spectrophotometric assay for angiotensin converting enzyme Anal Biochem 95 1979 540 548
36. M.M. Bradford A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein dye binding Anal Biochem 72 1976 248 254
37. K. Berg, L. Zhai, A. Chen, A. Kharazmi, and T.C. Owen Use of water soluble formazan complex to quantitate the cell number and mitochondrial function of Leishmania major promastigotes Parasitol Res 80 1994 235 239
38. C. Dumas, M. Ouellette, and J. Tovar Distruption of trypanothione reductase gene of Leishmania decreases its ability to survive oxidative stress in macrophages EMBO J 1 1997 2590 2598
39. B. Henrich, S. Becker, U. Schroeder, and R. Plapp dcp Gene of Escherichia coli: cloning, sequencing, transcript mapping and characterization of the gene product J Bacteriol 175 1993 7290 7300
40. C. Yao, J.E. Donelson, and M.E. Wilson The major surface protease (MSP or GP63) of Leishmania species: biosynthesis, regulation of expression and function Mol Biochem Parasitol 132 2003 1 16
41. J.C. Mottram, A.E. Souza, J.E. Hutchinson, R. Carter, M.J. Frame, and G.H. Coombs Evidence from disruption of the Lmcpb gene array of Leishmania mexicana that cysteine proteinases are virulence factors Proc Natl Acad Sci USA 93 1996 6008 6013
42. P.M. Selzer, S. Pingel, and I. Hseih Cysteine proteinase inhibitors as chemotherapy: lessons from parasite target Proc Natl Acad Sci USA 96 1999 11015 11022
43. S. Rafati, A.H. Salmanian, T. Tahei, M. Vafa, and N. Fasel A protective cocktail vaccine against murine cutaneous leishmaniasis with DNA encoding cysteine proteinases of Leishmania major Vaccine 19 2001 3369 3375
44. J.D. Bang, D.A. Ransom, D.A. Nimik, G. Christie, and N.M. Hooper In vitro cytocidal effect on Trypanosoma brucei and inhibition of Leishmania major GP 63 by peptidomimetic metalloprotease inhibitor Mol Biochem Parasitol 114 2001 111 117
45. R.E. Morty, L. Troebeg, J.C. Powers, S. Ono, J.D.S. Lonsdale-Eccles, and T.H.T. Coetzer Chracterization of antitrypanosomal activity of peptidyl amino alkyl phosphonate diphenyl esters Biochem Pharmacol 60 2000 1497 1506
46. A. Pierotti, K.W. Dong, M.J. Glucksman, M. Orlowski, and J.L. Robert Molecular cloning and primary structure of rat testes metalloendopeptidase E.C.3.4.24.15 Biochemistry 29 1990 10323 10329
47. C.A. Colin, and C.G. Miller Cloning and nucleotide sequence of opdA, the gene encoding oligopeptidaseA in Salmonella typhimurium J Bacteriol 174 1992 1631 1640
48. P.A. Bolle, V. Gilliquet, G. Berben, J. Dumont, and F. Hilger Yeast sequencing reports: the complete sequence of K3b, a 7.9 kb fragment between PKG1on chromosome 11 reveals the presence of seven open reading frames Yeast 8 1992 205 213
49. S. Hamilton, and C.G. Miller Cloning and nucleotide sequence of Salmonella typhimurium dcp gene encoding dipeptidyl carboxypaptidase J Bacteriol 174 1992 1626 1630
50. C. Yen, L. Green, and C.G. Miller Degradation of intracellular proteins in Salmonella typhimurium peptidase mutants J Mol Biol 143 1980 21 23
51. C.G. Miller, and L. Green Degradation of abnormal proteins in peptidase deficient mutants of Salmonella typhimurium J Bacteriol 147 1981 925 930
52. P.M. Rainey, T.W. Spithill, D. McMahon-Pratt, and A.A. Pan Biochemical and Molecular characterization of L. pifanoi amastigotes in continous axenic culture Mol Biochem Parasitol 49 1991 111 118
53. D.W. Cushman, H.S. Cheung, E.F. Sabo, and M.P. Ondetti Design of potent competitive inhibitors of angiotensin converting enzymes: carboxyalkanoyl and mercaptoalkanoyl amino acids Biochemistry 16 1977 5484 5491
54. E.R. Vimr, and C.C. Miller Dipeptidylcarboxypaptidase deficient mutants of Salmonella typhimurium J Bacteriol 153 1983 1252 1258