Design, synthesis, and molecular modeling of a novel amide-linked cyclic GnRH analogue cyclo(4-9)[Lys4,D-Trp6,Glu9]GnRH: Stimulation of gonadotropin gene expression

Journal of Medicinal Chemistry

Volumn 49, Issue 1, 2006, Pages 105-110

  Keramida, Maria K ^a,e   Tselios, Theodore ^a   Mantzourani, Efthimia ^a,c   Papazisis, Kostas ^d   Mavromoustakos, Thomas ^c   Klaussen, Christian ^b   Agelis, George ^a   Deraos, Spyros ^a   Friligou, Irene ^a   Habibi, Hamid ^b   Matsoukas, John ^a  

^a UNIVERSITY OF PATRAS   (Greece)

^b UNIVERSITY OF CALGARY   (Canada)

^c INSTITUTE OF BIOLOGY   (Greece)

^d ARISTOTLE UNIVERSITY OF THESSALONIKI   (Greece)

^e Medical School of Patras   (Greece)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLO(GLUTAMYLHISTIDYLTRYPTOPHYLLYSYLTYROSYLTRYPTOPHYLLEUCYLARGINYLGLUTAMYL GLYCINAMIDE); GONADORELIN DERIVATIVE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYCLIZATION; DRUG CONFORMATION; DRUG DESIGN; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; GENE EXPRESSION; GOLDFISH; HYPOPHYSIS; MOLECULAR MODEL; NONHUMAN; REACTION ANALYSIS; SIMULATION;

AMIDES; ANIMALS; CELL SURVIVAL; CELLS, CULTURED; CYCLIZATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; GENE EXPRESSION REGULATION; GOLDFISH; GONADOTROPIN-RELEASING HORMONE; GONADOTROPINS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PEPTIDES, CYCLIC; PITUITARY GLAND; PROTEIN CONFORMATION; RNA, MESSENGER;

EID: 30544433239     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm050683z     Document Type: Article

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