Design, synthesis and biological evaluation of cyclic angiotensin II analogues with 3,5 side-chain bridges: Role of C-terminal aromatic residue and ring cluster for activity and implications in the drug design of AT1 non-peptide antagonists

Bioorganic and Medicinal Chemistry Letters

Volumn 12, Issue 18, 2002, Pages 2627-2633

  Roumelioti, Panagiota ^a   Polevaya, Ludmila ^b   Zoumpoulakis, Panagiotis ^c   Giatas, Nektarios ^a   Mutule, Ilze ^b   Keivish, Tatjana ^b   Zoga, Anastasia ^c   Vlahakos, Demetrios ^d   Iliodromitis, E ^d   Kremastinos, Demetrios ^d   Grdadolnik, Simona Golic ^e   Mavromoustakos, Thomas ^b   Matsoukas, John ^a  

^a UNIVERSITY OF PATRAS   (Greece)

^b LATVIAN INSTITUTE OF ORGANIC SYNTHESIS   (Latvia)

^c INSTITUTE OF BIOLOGY   (Greece)

^d ONASSIS CARDIAC SURGERY CENTER   (Greece)

^e NATIONAL INSTITUTE OF CHEMISTRY   (Slovenia)

Author keywords

[No Author keywords available]

Indexed keywords

1 [[2' [(N BENZYL)TETRAZOL 5 YL]BIPHENYL 4 YL]METHYL] 2 HYDROXYMETHYLBENZIMIDAZOLE; ANGIOTENSIN ANTAGONIST; ANGIOTENSIN DERIVATIVE; ANGIOTENSIN GAMMA,EPSILON CYCLO(3,5) [1 SARCOSINE 3 GLUTAMINE 5 LYSINE 8 ISOLEUCINE]; ANGIOTENSIN GAMMA,EPSILON CYCLO(3,5) [1 SARCOSINE 3 GLUTAMINE 5 LYSINE 8 PHENYLALANINE]; BZI 8; HORMONE RECEPTOR STIMULATING AGENT; IMIDAZOLE; LOSARTAN; TETRAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; DOSE RESPONSE; DRUG DESIGN; DRUG EFFECT; DRUG STRUCTURE; DRUG SYNTHESIS; HYPERTENSION; MALE; NONHUMAN; PHARMACOPHORE; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

ANGIOTENSIN II; ANIMALS; DRUG DESIGN; MODELS, MOLECULAR; PEPTIDES, CYCLIC; RABBITS; STRUCTURE-ACTIVITY RELATIONSHIP;

ORYCTOLAGUS CUNICULUS;

EID: 0037119813     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(02)00474-2     Document Type: Article

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