Design of potent dicyclic (1-5/4-10) gonadotropin releasing hormone (GnRH) antagonists

Journal of Medicinal Chemistry

Volumn 43, Issue 5, 2000, Pages 807-818

  Rivier, Jean E ^a   Jiang, Guangcheng ^a   Struthers, R Scott ^b   Koerber, Steven C ^a   Porter, John ^a   Cervini, Laura A ^a   Kirby, Dean A ^a   Craig, A Grey ^a   Rivier, Catherine L ^c  

^a SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

^b NEUROCRINE BIOSCIENCES INC   (United States)

^c NONE

Author keywords

[No Author keywords available]

Indexed keywords

GONADORELIN ANTAGONIST; GONADORELIN RECEPTOR;

AMINO ACID SUBSTITUTION; ARTICLE; CHEMICAL BOND; DRUG CONFORMATION; DRUG DESIGN; DRUG POTENCY; DRUG RECEPTOR BINDING; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; OVULATION INHIBITION; RAT; RECEPTOR AFFINITY; STRUCTURE ACTIVITY RELATION;

ANIMALS; CELL LINE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; ELECTROPHORESIS, CAPILLARY; FEMALE; GONADOTROPIN-RELEASING HORMONE; HORMONE ANTAGONISTS; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; MODELS, MOLECULAR; OVULATION; PEPTIDES, CYCLIC; RATS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0034624688     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm990116+     Document Type: Article

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