Structural comparison between type I and type II antagonists: Possible implications in the drug design of AT1 antagonists

Bioorganic and Medicinal Chemistry Letters

Volumn 10, Issue 8, 2000, Pages 755-758

  Roumelioti, Panagiota ^a   Tselios, Theodoros ^a   Alexopoulos, Konstantinos ^a   Mavromoustakos, Thomas ^b   Kolocouris, Antonios ^d   Moore, Graham J ^c   Matsoukas, John M ^a  

^a UNIVERSITY OF PATRAS   (Greece)

^b INSTITUTE OF BIOLOGY   (Greece)

^c UNIVERSITY OF CALGARY   (Canada)

^d NONE

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOTENSIN 1 RECEPTOR; ANGIOTENSIN II [1 SARCOSINE 8 ISOLEUCINE]; ANGIOTENSIN II [1 SARCOSINE 8 ISOLEUCINE] DERIVATIVE; SARMESIN; SARMESIN DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CONFORMATIONAL TRANSITION; DRUG DESIGN; DRUG STRUCTURE; NONHUMAN; PARTIAL DRUG SYNTHESIS; RAT; RECEPTOR BLOCKING; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

ANGIOTENSIN I; ANGIOTENSIN II; ANIMALS; DRUG DESIGN; FEMALE; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; RATS; RECEPTORS, ANGIOTENSIN; STRUCTURE-ACTIVITY RELATIONSHIP; UTERUS;

ANIMALIA;

EID: 0034678836     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(00)00079-2     Document Type: Article

References (11)

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3. (a) Matsoukas, J. M.; Hondrelis, J.; Keramida, M.; Mavromoustakos, T.; Makriyannis, A.; Yamdagni, R.; Wu, Q.; Moore, G. J. J. Biol. Chem. 1994, 269, 5303.
4. (b) Carpenter, A. K.; Wilkes, C. B.; Schiller, P. W. Eur. J. Biochem. 1998, 251, 448.
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7. Matsoukas J.M., Agelis G., Wahhab A., Hondrelis J., Panagiotopoulos D., Yamdagni R., Wu Q., Mavromoustakos T., Maia H.L.S., Ganter R., Moore G.J. J. Med. Chem. 38:1995;4660.
8. Matsoukas J.M., Agelis G., Hondrelis J., Yamdagni R., Wu Q., Ganter R., Smith J.R., Moore D., Moore G.J. J. Med. Chem. 36:1993;904.
9. Mavromoustakos T., Kolocouris A., Zervou M., Roumelioti P., Matsoukas J.M., Weisemann R. J. Med. Chem. 42:1999;1714.
10. Matsoukas J.M., Cordopatis P., Belte U., Goghari M.H., Ganter R.C., Franklin K.J., Moore G.J. J. Med. Chem. 31:1988;1418.
11. Models were generated using the QUANTA package and CHARMm force field. Low energy conformations A-H were resulted using a combination of molecular dynamics and NOE distance constraints. For details see ref 8.