Consensus bioactive conformation of cyclic GnRH antagonists defined by NMR and molecular modeling

Journal of Medicinal Chemistry

Volumn 43, Issue 5, 2000, Pages 819-828

  Koerber, Steven C ^a   Rizo, Josep ^b   Struthers, R Scott ^c   Rivier, Jean E ^a  

^a SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^c NEUROCRINE BIOSCIENCES INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 (N BENZYL N METHYLAMINOMETHYL) 7 (2,6 DIFLUOROBENZYL) 4,7 DIHYDRO 2 (4 ISOBUTYRYLAMINOPHENYL) 4 OXOTHIENO[2,3 B]PYRIDINE 5 CARBOXYLIC ACID ISOPROPYL ESTER; GONADORELIN ANTAGONIST; UNCLASSIFIED DRUG;

ARTICLE; DRUG BINDING; DRUG CONFORMATION; DRUG DESIGN; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG STRUCTURE; HYDROGEN BOND; MOLECULAR MODEL; NUCLEAR MAGNETIC RESONANCE;

ANIMALS; FEMALE; GONADOTROPIN-RELEASING HORMONE; HORMONE ANTAGONISTS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; MOLECULAR CONFORMATION; OVULATION; PEPTIDES, CYCLIC; PITUITARY GLAND; PYRIDONES; RATS; SOLUTIONS; THIOPHENES;

EID: 0034624823     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm990118u     Document Type: Article

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