Coating of mannan on LPD particles containing HPV E7 peptide significantly enhances immunity against HPV-positive tumor

Pharmaceutical Research

Volumn 21, Issue 6, 2004, Pages 1018-1025

  Cui, Zhengrong ^a   Han, Su Ji ^a   Huang, Leaf ^a  

^a UNIVERSITY OF PITTSBURGH   (United States)

Author keywords

antigen presenting cells; liposome; mannan; peptide; tumor vaccine

Indexed keywords

ARGINYLALANYLHISTIDYLTYROSYLASPARAGINYLISOLEUCYLVALYLTHREONYLPHENYLALANINE; DNA; LIPOSOME; MANNAN; PEPTIDE DERIVATIVE; PROTAMINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN EXPRESSION; ANTIGEN PRESENTING CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER; CELL ISOLATION; CELL STIMULATION; CONTROLLED STUDY; DENDRITIC CELL; DRUG COATING; DRUG CONJUGATION; DRUG TARGETING; DRUG UPTAKE; FEMALE; IMMUNE RESPONSE; IMMUNIZATION; INCUBATION TIME; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SPLEEN CELL;

ANIMALS; ANTIGENS, CD; ANTIGENS, CD80; ANTIGENS, CD86; CELLS, CULTURED; CHOLESTEROL; DENDRITIC CELLS; DISEASE MODELS, ANIMAL; DNA; GENE EXPRESSION; GENE TRANSFER TECHNIQUES; HUMANS; LIPOSOMES; MANNANS; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED STRAINS; NANOTECHNOLOGY; ONCOGENE PROTEINS, VIRAL; PARTICLE SIZE; PROTAMINES; PROTEIN BINDING;

EID: 3042809887     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/B:PHAM.0000029292.66792.4f     Document Type: Article

References (31)

1. N. Renkvist, C. Castelli, P. F. Robbins, and G. Parmiani. A listing of human tumor antigens recognized by T cells. Cancer Immunol. Immunother. 50:3-15 (2001).
2. G. Parmiani, M. Sensi, C. Castelli, L. Rivoltini, and A. Anichini. T-cell response to unique and shared antigens and vaccination of cancer patients. Cancer Immun. 2:6-15 (2002).
3. G. Ada Vaccines and vaccination. N. Engl. J. Med. 345:1042-1053 (2001).
4. L. Fong and E. G. Engleman. Dendritic cells in cancer immunotherapy. Annu. Rev. Immunol. 18:245-273 (2000).
5. S. Li and L. Huang. In vivo gene transfer via intravenous administration of cationic lipid-protamine-DNA (LPD) complexes. Gene Ther. 4:891-900 (1997).
6. S. Li, M. A. Rizzo, S. Bhattacharya, and L. Huang. Characterization of cationic lipid-protamine-DNA (LPD) complexes for intravenous gene delivery. Gene Ther. 5:930-937 (1998).
7. M. S. Whitmore, S. Li, and L. Huang. LPD lipopolyplex initiates a potent cytokine response and inhibits tumor growth. Gene Ther. 6:1867-1875 (1999).
8. M. Whitmore. Systemic administration of LPD prepared with CpG oligonucleotides inhibits the growth of established pulmonary metastases by stimulating innate and acquired antitumor immune responses. Cancer Immunol. Immunother. 50:503-14 (2001).
9. J. Dileo, R. Banerjee, M. Whitmore, J. V. Nayak, L. Falo Jr., and L. Huang. Lipid-protamine-DNA-mediated antigen delivery to antigen-presenting cells results in enhanced anti-tumor immune responses. Mol. Ther. 7:640-648 (2003).
10. A. F. Ochsenbein, P. Klenerman, U. Karrer, B. Ludewig, M. Pericin, H. Hengartner, and R. Zinkernagel. Immune surveillance against a solid tumor fails because of immunological ignorance. Proc. Natl. Acad. Sci. USA 96:2233-2238 (1999).
11. R. Zinkernagel, S. Ehl, P. Aichele, S. Oehen, T. Kundig, and H. Hengartner. Antigen localisation regulates immune responses in a dose- and time-dependent fashion: a geographical view of immune reactivity. Immunol. Rev. 156:199-209 (1997).
12. O. Akbari, N. Panjwani, S. Garcia, R. Tascon, D. Lowrie, and B. Stockinger. DNA vaccination: transfection and activation of dendritic cells as key events for immunity. J. Exp. Med. 189:169-178 (1999).
13. C. Condon, S. watkins, C. Celluzzi, K. Thompson, L. Falo, Jr. DNA-based immunization by in vivo transfection of dendritic cells. Nat. Med. 2:1122-1128 (1996).
14. A. Porgador, K. Irvine, A. Iwasaki, B. Barber, N. Restifo, and R. Germain. Predominant role for directly transfected dendritic cells in antigen presentation to CD8+ T cells after gene gun immunization. J. Exp. Med. 188:1075-1082 (1998).
15. U. Karrer, A. Althage, B. Odermatt, C. Roberts, S. Korsmeyer, S. Miyawaki, H. Hengartner, and R. M. Zinkernagel. On the key role of secondary lymphoid organs in antiviral immune responses studied in alymphoplastic (aly/aly) and spleenless (Hox11(-)/-) mutant mice. J. Exp. Med. 185:2157-2170 (1997).
16. A. Avrameas, D. McIlroy, A. Hosmalin, B. Autran, P. Debre, M. Monsigy, A. C. Roche, P. Midoux. Expression of a mannose/fucose membrane lectin on human dendritic cells. Eur. J. Immunol. 26:394-400 (1996).
17. I. McKenzie, V. Apostolopoulos, C. Lees, P. Xing, S. Lofthouse, C. Osinski, V. Popouski, B. Acres, G. Pietersz. Oxidised mannan antigen conjugates preferentially stimulate T1 type immune responses. Vet. Immunol. Immunopathol. 63:185-190 (1998).
18. M. Fukasawa, Y. Shimizu, K. Shikata, M. Nakata, R. Sakakibara, N. Yamamoto, M. Hatanaka, T. Mizuochi. Liposome oligomannose-coated with neoglycolipid, a new candidate for a safe adjuvant for induction of CD8+ cytotoxic T lymphocytes. FEBS Lett. 441:353-356 (1998).
19. V. Apostolopoulos, N. Barnes, G. Pietersz, and I. McKenzie. Ex vivo targeting of the macrophage mannose receptor generates anti-tumor CTL responses. Vaccine 18:3174-3184 (2000).
20. M. Gadjeva, S. Thiel, and J. C. Jensenius. The mannan-binding-lectin pathway of the innate immune response. Curr. Opin. Immunol. 13:74-78 (2001).
21. N. Okada, T. Saito, K. Mori, Y. Masunag, Y. Fujii, J. Fujita, K. Fujimoto, T. Nakanishi, K. Tanaka, S. Nakagawa, T. Mayumi, T. Fujita, A. Yamamoto. Effects of lipofectin-antigen complexes on major histocompatibility complex class I-restricted antigen presentation pathway in murine dendritic cells and on dendritic cell maturation. Biochim. Biophys. Acta 1527:97-101 (2001).
22. S. Toda, N. Ishii, E. Okada, K. Kusakabe, H. Arai, K. Hamajima, I. Gorai, K. Nishioka, K. Okuda. HIV-1-specific cell-mediated immune responses induced by DNA vaccination were enhanced by mannan-coated liposomes and inhibited by anti-interferon-gamma antibody. Immunology 92:111-117 (1997).
23. Z. Cui and R. J. Mumper. Topical immunization using nanoengineered genetic vaccines. J. Control. Rel. 81:173-184 (2002).
24. J. C. Brown and R. C. Hunt. Lectins. Int. Rev. Cytol. 52:277-349 (1978).
25. M. Dittgen and B. Herbst. Zeta potential - fundamentals, measurement methods and application to pharmacy. Pharmazie 42:641-656 (1987).
26. L. East and C. M. Isacke. The mannose receptor family. Biochim. Biophys. Acta 1572:364-386 (2002).
27. C. Howard, J. Hope, S. Stephens, D. Gliddon, and G. Brooke. Co-stimulation and modulation of the ensuing immune response. Vet. Immunol. Immunopathol. 87:123-130 (2002).
28. S. M. Moghimi, A. E. Hawley, N. M. Christy, T. Gray, L. Illum, and S. S. Davis. Surface engineered nanospheres with enhanced drainage into lymphatics and uptake by macrophages of the regional lymph nodes. FEBS Lett. 344:25-30 (1994).
29. T. Nakanishi, J. Kunisawa, A. Hayashi, Y. Tsutsumi, K. Kubo, S. Nakagawa, H. Fujiwara, T. Hamaoka, T. Mayumi. Positively charged liposome functions as an efficient immunoadjuvant in inducing immune responses to soluble proteins. Biochem. Biophys. Res. Commun. 240:793-797 (1997).
30. W. Jiang and D. S. Pisetsky. Enhancing immunogenicity by CpG DNA. Curr. Opin. Mol. Ther. 5:180-185 (2003).
31. B. Li, S. Li, T. Tan, D. B. Stolz, S. Watkins, L. Block, and L. Huang. Lyophilization of cationic lipid-protamine-DNA (LPD) complexes. J. Pharm. Sci. 89:355-364 (2000).