Oxidised mannan antigen conjugates preferentially stimulate T1 type immune responses

Veterinary Immunology and Immunopathology

Volumn 63, Issue 1-2, 1998, Pages 185-190

  McKenzie, Ian F C ^a   Apostolopoulos, Vasso ^a   Lees, Catherine ^a   Xing, P X ^a   Lofthouse, Shari ^a   Osinski, Carla ^a   Popovski, Violeta ^a   Acres, Bruce ^b   Pietersz, Geoff ^a  

^a AUSTIN RESEARCH INSTITUTE   (Australia)

^b TRANSGENE S A   (France)

Author keywords

Antigen; Immune response; Mannan

Indexed keywords

ANTIBODY; ANTIGEN; CYTOKINE; GAMMA INTERFERON; HYBRID PROTEIN; INTERLEUKIN 12; INTERLEUKIN 2; INTERLEUKIN 4; KEYHOLE LIMPET HEMOCYANIN; MANNAN; MANNOSE; MUCIN;

ANIMAL EXPERIMENT; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; DRUG CONJUGATION; HELPER CELL; IMMUNE RESPONSE; IMMUNIZATION; IMMUNOGENICITY; LYMPHOCYTE DIFFERENTIATION; MAJOR HISTOCOMPATIBILITY COMPLEX RESTRICTION; MOUSE; NONHUMAN; OXIDATION; REVIEW;

ANIMALIA;

EID: 0032524481     PISSN: 01652427     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-2427(98)00094-4     Document Type: Article

References (9)

1. Apostolopoulos, V., Loveland, B.E., Pietersz, G.A., McKenzie, I.F.C., 1995a. CTL in mice immunised with human Mucin 1 are MHC-restricted. J. Immunol. 155, 5089-5094.
2. Apostolopoulos, V., Pietersz, G.A., Loveland, B.E., Sandrin, M.S., McKenzie, I.F.C., 1995b. Oxidative/reductive conjugation of mannan to antigen selects for T1 or T2 immune responses. Proc. Natl. Acad. Sci. U.S.A. 92, 10128-10132.
3. Apostolopoulos, V., McKenzie, I.F.C., Pietersz, G.A., 1996a. Breast cancer immunotherapy - Current status and Future prospects. Immunol. Cell Biol. 74, 457-464.
4. Apostolopoulos, V., Pietersz, G.A., McKenzie, I.F.C., 1996b. Cell-mediated immune responses to MUC1 fusion protein coupled to mannan. Vaccine 14, 930-938.
5. Barnd, D.L., Lan, M.S., Metzgar, R.S., Finn, O.J., 1989. Specific major histocompatibility complex-unrestricted recognition of tumour-associated mucins by human cytotoxic T cells. Proc. Natl. Acad. Sci. U.S.A. 86, 7159-7163.
6. Gendler, S.J., Papadimitriou, J.T., Duhig, T., Rothbard, J., Burchell, J., 1989. A highly immunogenic region of a human polymorphic epithelial mucin expressed by carcinomas is made up of tandem repeats. J. Biol. Chem. 263, 12820-12823.
7. Papadimitriou, J.T., Stewart, L., Burchell, J., Beverley, P., 1994. The polymorphic epithelial mucin as a target for immunotherapy. Ann. New York Acad. Sci. 690, 69-79.
8. Xing, P.X., Micahels, M., Apostolopoulos, V., Prenzoska, J., Bishop, J., McKenzie, I.F.C., 1995. Phase I study of synthetic MUC1 peptides in cancer. Int. J. Oncol. 6, 1283-1289.
9. Xing, P.X., Reynolds, K., Tjandra, J.J., Tang, X.L., McKenzie, I.F.C., 1990. Synthetic peptides reactive with anti-human milk fat globule membrane monoclonal antibodies. Cancer Res. 50, 89-96.