Increased Immunogenicity of Colon Cancer Cells by Selective Depletion of Cytochrome c

Cancer Research

Volumn 64, Issue 8, 2004, Pages 2705-2711

  Schmitt, Elise ^a   Parcellier, Arnaud ^a   Ghiringhelli, François ^a   Casares, Noelia ^b   Gurbuxani, Sandeep ^a   Droin, Nathalie ^a   Hamai, Ahmed ^b   Pequignot, Marie ^b   Hammann, Arlette ^a   Moutet, Monique ^a   Fromentin, Annie ^a   Kroemer, Guido ^b   Solary, Eric ^a   Garrido, Carmen ^a  

^a UNIVERSITÉ DE BOURGOGNE   (France)

^b CNRS   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; ANTISENSE OLIGONUCLEOTIDE; CYTOCHROME C; REACTIVE OXYGEN METABOLITE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; AUTOPHAGY; CANCER CHEMOTHERAPY; CARCINOGENICITY; CELL DEATH; CELL GROWTH; COLON CANCER; CONTROLLED STUDY; ENZYME DEFICIENCY; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IMMUNOCOMPETENCE; IMMUNOGENICITY; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SENSITIZATION; TUMOR IMMUNITY;

ANIMALS; APOPTOSIS; CISPLATIN; COLONIC NEOPLASMS; CYTOCHROMES C; DNA, ANTISENSE; DOWN-REGULATION; DOXORUBICIN; ETOPOSIDE; HCT116 CELLS; HT29 CELLS; HUMANS; MACROPHAGES; MICE; RATS; STAUROSPORINE; TRANSFECTION;

EID: 3042802080     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-03-2475     Document Type: Article

References (35)

1. Kiaris H, Schally AV. Apoptosis versus necrosis: which should be the aim of cancer therapy? Proc Soc Exp Biol Med 1999;221:87-8.
2. Melcher A, Gough M, Todryk S, Vile R. Apoptosis or necrosis for tumor immunotherapy: what's in a name? J Mol Med 1999;77:824-33.
3. Garrido C, Fromentin A, Bonnotte B, et al. Heat shock protein 27 enhances the tumorigenicity of immunogenic rat colon carcinoma cell clones. Cancer Res 1998;58:5495-9.
4. Bonnotte B, Favre N, Moutet M, et al. Bcl-2-mediated inhibition of apoptosis prevents immunogenicity and restores tumorigenicity of spontaneously regressive tumors. J Immunol 1998;161:1433-8.
5. Bruey JM, Paul C, Fromentin A, et al. Differential regulation of HSP27 oligomerization in tumor cells grown in vitro and in vivo. Oncogene 2000;19:4855-63.
6. Gurbuxani S, Bruey JM, Fromentin A, et al, Selective depletion of inducible HSP70 enhances immunogenicity of rat colon cancer cells. Oncogene 2001;20:7478-85.
7. Newmeyer DD, Ferguson-Miller S. Mitochondria: releasing power for life and unleashing the machineries of death. Cell 2003;112:481-90.
8. Ravagnan L, Roumier T, Kroemer G. Milochondria, the killer organelles and their weapons. J Cell Physiol 2002;192:131-7.
9. Lee HC, Wei YH. Mitochondrial role in life and death of the cell. J Biomed Sci 2000;7:2-15.
10. Li P, Nijhawan D, Budihardjo I, et al. Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Cell 1997;91:479-89.
11. Zhivotovsky B, Hanson KP, Orrenius S. Back to the future: the role of cytochrome c in cell death. Cell Death Differ 1998;5:459-60.
12. Zhivotovsky B, Orrenius S, Brustugun OT, Doskeland SO. Injected cytochrome c induces apoptosis. Nature 1998;391:449-50.
13. Zou H, Li Y, Liu X, Wang X. An APAF-1 cytochrome c multimeric complex is a functional apoptosome that activates procaspase-9. J Biol Chem 1999;274:11549-56.
14. Thornberry NA, Lazebnik Y. Caspases: enemies within. Science 1998;281:1312-6.
15. Rodriguez A, Oliver H, Zou H, Chen P, Wang X, Abrams JM. Dark is a Drosophila homologue of Apaf-1/CED-4 and functions in an evolutionarily conserved death pathway. Nat Cell Biol 1999;1:272-9.
16. Li K, Li Y, Shelton JM, et al. Cytochrome c deficiency causes embryonic lethality and attenuates stress-induced apoptosis. Cell 2000;101:389-99.
17. Costantini P, Jacotot E, Decaudin D, Kroemer G. Mitochondrion as a novel target of anticancer chemotherapy. J Natl Cancer Inst (Bethesda) 2000;92:1042-53.
18. Garrido C, Bruey JM, Fromentin A, Hammann A, Arrigo AP, Solary E. HSP27 inhibits cytochrome c-dependent activation of procaspase-9. FASEB J 1999;13:2061-70.
19. Larmonier N, Ghiringhelli F, Larmonier CB, et al. Freshly isolated bone marrow cells induce death of various carcinoma cell lines. Int J Cancer 2003;107:747-56.
20. Chen LB. Mitochondrial membrane potential in living cells. Annu Rev Cell Biol 1988;4:155-81.
21. Eguchi Y, Shimizu S, Tsujimoto Y. Intracellular ATP levels determine cell death fate by apoptosis or necrosis. Cancer Res 1997;57:1835-40.
22. Kroemer G, Dallaporta B, Resche-Rigon M. The mitochondrial death/life regulator in apoptosis and necrosis. Annu Rev Physiol 1998;60:619-42.
23. Leist M, Single B, Castoldi AF, Kuhnle S, Nicotera P. Intracellular adenosine triphosphate (ATP) concentration: a switch in the decision between apoptosis and necrosis. J Exp Med 1997;185:1481-6.
24. Leist M, Nicotera P. The shape of cell death. Biochem Biophys Res Commun 1997;236:1-9.
25. Raha S, Robinson BH. Mitochondria, oxygen free radicals, and apoptosis. Am J Med Genet 2001;106:62-70.
26. Vercammen D, Beyaert R, Denecker G, et al. Inhibition of caspases increases the sensitivity of L929 cells to necrosis mediated by tumor necrosis factor. J Exp Med 1998;187:1477-85.
27. Sordet O, Rebe C, Plenchette S, et al. Specific involvement of caspases in the differentiation of monocytes into macrophages. Blood 2002;100:4446-53.
28. Bruey JM, Ducasse C, Bonniaud P, et al. Hsp27 negatively regulates cell death by interacting with cytochrome c. Nat Cell Biol 2000;2:645-52.
29. Slee EA, Harte MT, Kluck RM, et al. Ordering the cytochrome c-initiated caspase cascade: hierarchical activation of caspases-2, -3, -6, -7, -8, and -10 in a caspase-9-dependent manner. J Cell Biol 1999;144:281-92.
30. Bonnotte B, Larmonier N, Favre N, et al. Identification of tumor-infiltrating macrophages as the killers of tumor cells after immunization in a rat model system. J Immunol 2001;167:5077-83.
31. Favre-Felix N, Martin M, Maraskovsky E, et al. Flt3 ligand lessens the growth of tumors obtained after colon cancer cell injection in rats but does not restore tumor-suppressed dendritic cell function. Int J Cancer 2000;86:827-34.
32. Caignard A, Pelletier H, Martin F. Specificity of the immune response leading to protection or enhancement by regressive and progressive variants of a rat colon carcinoma. Int J Cancer 1988;42:883-6.
33. Gough MJ, Melcher AA, Ahmed A, et al. Macrophages orchestrate the immune response to tumor cell death. Cancer Res 2001;61:7240-7.
34. Strome SE, Voss S, Wilcox R, et al. Strategies for antigen loading of dendritic cells to enhance the antitumor immune response. Cancer Res 2002;62:1884-9.
35. Reiter I, Krammer B, Schwamberger G. Cutting edge: differential effect of apoptotic versus necrotic tumor cells on macrophage antitumor activities. J Immunol 1999;163:1730-2.