mRNA quality control: Marking the message for life or death

Current Biology

Volumn 11, Issue 3, 2001, Pages

  Lykke Andersen, Jens ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMALIA;

EID: 0035125142     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-9822(01)00036-7     Document Type: Review

References (29)

1. The spliceosome deposits multiple proteins 20-24 nucleotides upstream of mRNA exon-exon junctions
2. The protein Aly links pre-messenger-RNA splicing to nuclear export in metazoans
3. Human Upf proteins target an mRNA for nonsense-mediated decay when bound downstream of a termination codon
4. Novel Upf2p orthologues suggest a functional link between the translation initiation and nonsense surveillance complexes
5. Identification and characterization of human orthologues to S. cerevisiae Upf2 protein and S. cerevisiae Upf3 protein/C. elegans SMG-4
6. Nuclear RNA export pathways
7. Transport of proteins and RNAs in and out of the nucleus
8. TAP, the human homolog of Mex67p, mediates CTE-dependent RNA export from the nucleus
9. mRNA export: The long and winding road
10. Pre-mRNA splicing imprints mRNA in the nucleus with a novel RNA-binding protein that persists in the cytoplasm
11. The acute myeloid leukemia-associated protein, DEK, forms a splicing-dependent interaction with exon-product complexes
12. A co-activator of pre-mRNA splicing
13. Purification and characterization of human RNPS1: A general activator of pre-mRNA splicing
14. REF, an evolutionary conserved family of hnRNP-like proteins, interacts with TAP/Mex67p and participates in mRNA nuclear export
15. Nonsense-mediated RNA decay in mammalian cells: A splicing-dependent means to down-regulate the levels of mRNAs that prematurely terminate translation
16. A rule for termination-codon position within intron-containing genes: When nonsense affects RNA abundance
17. Should we kill the messenger? The role of the surveillance complex in translation termination and mRNA turnover
18. RNA surveillance. Unforeseen consequences for gene expression, inherited genetic disorders and cancer
19. Mechanisms of mRNA surveillance in eukaryotes
20. The yeast hnRNP-like protein Hrp1/Nab4 marks a transcript for nonsense-mediated mRNA decay
21. The RNA binding protein Pub1 modulates the stability of transcripts containing upstream open reading frames
22. Upf1p, Nmd2p, and Upf3p are interacting components of the yeast nonsense-mediated mRNA decay pathway
23. The surveillance complex interacts with the translation release factors to enhance termination and degrade aberrant mRNAs
24. The DCP2 protein is required for mRNA decapping in Saccharomyces cerevisiae and contains a functional MutT motif
25. mRNA surveillance by the Caenorhabditis elegans smg genes
26. A mutated human homologue to yeast Upf1 protein has a dominant-negative effect on the decay of nonsense-containing mRNAs in mammalian cells
27. A splicing-dependent regulatory mechanism that detects translation signals
28. Binary specification of nonsense codons by splicing and cytoplasmic translation
29. At least one intron is required for the nonsense-mediated decay of triosephosphate isomerase mRNA: A possible link between nuclear splicing and cytoplasmic translation