Xenografts are an achievable breakthrough

Medical Hypotheses

Volumn 63, Issue 1, 2004, Pages 92-97

  Alisky, Joseph Martin ^a  

^a MARSHFIELD CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CRE RECOMBINASE; GALACTOSYLGALACTOSE; GALACTOSYLTRANSFERASE;

ACUTE GRAFT REJECTION; BONE MARROW; CHIMERA; DNA MODIFICATION; FEASIBILITY STUDY; GENE MUTATION; GENETIC ENGINEERING; HUMAN; MOLECULAR CLONING; NONHUMAN; ORGAN DONOR; ORGAN TRANSPLANTATION; PRION DISEASE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECIPIENT; REVIEW; STOP CODON; SWINE; XENOGRAFT; ZOONOSIS;

PORCINE ENDOGENOUS RETROVIRUS; SUIDAE; SUS SCROFA; UNIDENTIFIED RETROVIRUS;

EID: 3042724907     PISSN: 03069877     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mehy.2004.01.023     Document Type: Article

References (56)

1. United Network for Organ Sharing. Organ procurement and transplantation network. US Transplantation Data. Available from: http://www.unos.org/
2. Sachs D.H. The pig as a xenograft donor. Pathol. Biol. (Paris). 42:1994;217-219
3. Dai Y., Vaught T.D., Boone J., et al. Targeted disruption of the. α 1, 3-galactosyltransferase gene in cloned pigs Nat. Biotechnol. 20:2002;251-255
4. Lai L., Kolber-Simonds D., Park K.W., et al. Production of. α -1, 3-galactosyltransferase knockout pigs by nuclear transfer cloning Science. 295:2002;1089-1092
5. Phelps C.J., Koike C., Vaught T.D., et al. Production of. α -1, 3-galactosyltransferase-deficient pigs Science. 299:2003;411-414
6. Campbell K.H., McWhir J., Ritchie W.A., Wilmut I. Sheep cloned by nuclear transfer from a cultured cell line. Nature. 380:1996;64-66
7. Polejaeva I.A., Chen S.-.H., Vaught T.D., et al. Cloned pigs produced by nuclear transfer from adult somatic cells. Nature. 407:2000;86-90
8. Summary of all published reports on mammalian cloning-somatic cell nuclear transfer cloning efficiency. Roslin Institute July 2002. Available from: http://www.roslin.ac.uk/public/cloning.html
9. Carter D.B., Lai L., Park K.W., et al. Phenotyping of transgenic cloned piglets. Cloning Stem Cells. 4:2002;131-145
10. Tsunoda Y., Kato Y. Recent progress and problems in animal cloning. Differentiation. 69:2002;158-161
11. Tamashiro K.L., Wakayma T., Akutsu H., et al. Cloned mice have an obese phenotype not transmitted to their offspring. Nat. Med. 8:2002;262-267
12. McManus R.P., O'Hair D.P., Komorowski R., Scott J.P. Immunosuppressant combinations in primate cardiac xenografts. A review. Ann. NY Acad. Sci. 696:1993;281-284
13. Hammer R.E., Pursel V.G., Rexroad C.E. Jr., et al. Production of transgenic rabbits, sheep and pigs by microinjection. Nature. 315:1985;680-683
14. Bondioli K., Ramsoondar J., Williams B., Costa C., Fodor W. Cloned pigs generated from cultured skin fibroblasts derived from a H-transferase transgenic boar. Mol. Reprod. Dev. 60:2001;189-195
15. Kuroiwa Y., Kasinathan P., Choi Y.J., et al. Cloned transchromosomic calves producing human immunoglobulin. Nat. Biotechnol. 20:2002;889-894
16. Adams D.H., Kadner A., Chen R.H., Farivar R.S. Human membrane cofactor protein (MCP, CD 46) protects transgenic pig hearts from hyperacute rejection in primates. Xenotransplantation. 8:2001;36-40
17. Bennet W., Bjorkland A., Sundberg B., et al. Expression of complement regulatory proteins of islets of Langerhans: a comparison between human islets and islets isolated from normal and hDAF transgenic pigs. Transplantation. 72:2001;312-319
18. Costa C., Zhao L., Decesare S., Fodor W.L. Comparative analysis of three genetic modifications designed to inhibit human serum-mediated cytolysis. Xenotransplantation. 6:1999;6-16
19. Fodor W.L., Williams B.L., Matis L.A., et al. Expression of a functional complement inhibitor in a transgenic pig as a model for the prevention of xenogeneic hyperacute organ rejection. Proc. Natl. Acad. Sci. USA. 91:1994;11153-11157
20. Kroshus T.J., Bolman R.M. III, Dalmasso A.P., et al. Expression of human CD59 in transgenic pig organs enhances organ survival in an ex vivo xenogeneic perfusion model. Transplantation. 61:1996;1513-1521
21. Niemann H., Verhoeyen E., Wonigeit K., et al. Cytomegalovirus early promoter induced expression of hCD59 in porcine organs provides protection against hyperacute rejection. Transplantation. 72:2001;1898-1906
22. Powell M.B., Marchbank K.J., Rushmere N.K., et al. Molecular cloning, chromosomal localization, expression and functional characterization of the mouse analogue of human CD59. J. Immunol. 158:1997;1692-1702
23. Takefman D.M., Spear G.T., Saifuddin M., Wilson C.A. Human CD59 incorporation into porcine endogenous retrovirus particles: implications for the use of transgenic pigs for xenotransplantation. J. Virol. 76:2002;1999-2002
24. Yeatman M., Daggett C.W., Parker W., et al. Complement-mediated pulmonary xenograft injury: studies in swine-to-primate orthoptic single lung transplant models. Transplantation. 65:1998;1084-1093
25. Yeatman M., Daggett C.W., Lau C.L., et al. Human complement regulatory proteins protect swine lungs from xenogeneic injury. Ann. Thorac. Surg. 67:1999;769-775
26. Zhou C.Y., McInnes E., Parsons N., et al. Production and characterization of a pig line transgenic for human membrane cofactor protein. Xenotransplanation. 9:2002;183-190
27. Levy M.F., Crippin J., Sutton S., et al. Liver allotransplantation after extracorporeal hepatic support with transgenic (hCD55/hCD59) porcine livers: clinical results and lack of pig-to-human transmission of porcine retrovirus. Transplantation. 69:2000;272-280
28. Costa C., Barber D.F., Fodor W.L. Human NK cell-mediated cytoxicity triggered by CD86 and Gal alpha 1, 3-Gal is inhibited in genetically modified porcine cells. J. Immunol. 168:2002;3808-3816
29. Tourneur L., Malassagne B., Batteux F., et al. Transgenic expression of CD95 ligand on thyroid follicular cells confers immune privilege upon thyroid allografts. J. Immunol. 167:2001;1338-1346
30. Takeuichi T., Ueki T., Nishimatsu H., et al. Accelerated rejection of Fas ligand-expressing heart grafts. J. Immunol. 162:1999;518-522
31. Whartenby K.A., Straley E.E., Kim H., et al. Transduction of donor hematopoietic stem-progenitor cells with Fas ligand enhanced short-term engraftment in a murine model of allogeneic bone marrow transplantation. Blood. 100:2002;3147-3154
32. Kapturczak M.H., Flotte T., Atkinson M.A. Adeno-associated virus (AAV) as a vehicle for therapeutic gene delivery: improvements in vector design and viral production enhance potential to prolong graft survival in pancreatic islet cell transplantation for the reversal of type I diabetes. Curr. Mol. Med. 1:2001;245-258
33. Gianello P. Existe-t-il une place pour la therapie genique en transplantation d'organes? [Is there a place for gene therapy in organ transplantation?]. Ann. Chir. 51:1997;593-604
34. Lasko M., Sauer B., Mosinger B. Jr., et al. Targeted oncogene activation by site-specific recombination in transgenic mice. Proc. Natl. Acad. Sci. USA. 89:1992;6232-6236
35. Stricklett P.K., Nelson R.D., Kohan D.E. The Cre/loxP system and gene targeting in the kidney. Am. J. Physiol. 276:1999;F651-F657
36. Schonig K., Schwenk F., Rajewsky K., Bujard H. Stringent doxycycline dependent control of CRE recombinase in vivo. Nucl. Acids Res. 30:2002;E134
37. Sohal D.S., Nghiem M., Crackower M.A., et al. Temporally regulated and tissue-specific gene manipulations in the adult and embryonic heart using tamoxifen-inducible Cre protein. Circ. Res. 89:2001;20-25
38. Tannour-Louet M., Porteu A., Vaulont S., Kahn A., Vasseur-Cognet M. A tamoxifen-inducible chimeric Cre recombinase specifically effective in the fetal and adult mouse liver. Hepatology. 35:2002;1072-1081
39. Starzl T.E., Demetris A.J., Trucco M., et al. Chimerism and donor-specific nonreactivity 27 to 29 years after kidney allotransplantation. Transplantation. 55:1993;1272-1277
40. Ciancio G., Miller J., Garcia-Morales R.O., et al. Six-year clinical effect of donor bone marrow infusions in renal transplant patients. Transplantation. 71:2001;827-835
41. Mathew J.M., Garcia-Morales R., Fuller L., et al. Donor bone marrow-derived chimeric cells present in renal transplant recipients infused with donor marrow. I. Potent regulators of recipient antidonor immune responses. Transplantation. 12:2000;1675-1682
42. Shapiro R., Rao A.S., Fontes P., et al. Combined simultaneous kidney/bone marrow transplantation. Transplantation. 12:1995;1421-1425
43. Millan M.T., Shizuru J.A., Hoffmann P., et al. Mixed chimerism and immuno-suppressive drug withdrawl after HLA-mismatched kidney and hematopoietic progenitor transplantation. Transplantation. 73:2002;1386-1391
44. Helg C., Chapuis B., Bolle J.F., et al. Renal transplantation without immuno-suppression in a host with tolerance induced by allogeneic bone marrow transplantation. Transplantation. 58:1994;1420-1422
45. Jacbosen N., Taaning E., Ladefoged J., Kristensen J.K., Pedersen F.K. Tolerance to an HLA-B, DR disparate kidney allograft after bone-marrow transplantation from same donor. Lancet. 343:1994;800
46. Sorof J.M., Koerper M.A., Portale A.A., Potter D., DeSantes K., Cowan M. Renal transplantation without chronic immunosuppression after T cell-depleted, HLA-mismatched bone marrow transplantation. Transplantation. 59:1995;1633-1635
47. Spitzer T.R., Delmonico F., Tolkoff-Rubin N., et al. Combined histocompatibility leukocyte antigen-matched donor bone marrow and renal transplantation for multiple myeloma with end stage renal disease: the induction of allograft tolerance through mixed lymphohematopoietic chimerism. Transplantation. 68:1999;480-484
48. Abe M., Qi J., Sykes M., Yang Y.G. Mixed chimerism induces donor-specific T-cell tolerance across a highly disparate xenogeneic barrier. Blood. 99:2002;3823-3829
49. Sachs D.H. Mixed chimerism as an approach to transplantation tolerance. Clin. Immunol. 95:2000;S63-S68
50. Ierino F., Gojo S., Banerjee P.T., et al. Transfer of swine major histocompatability complex class II genes into autologous bone marrow cells of baboons for the induction of tolerance across xenogeneic barriers. Transplantation. 67:1999;1119-1128
51. Mueller N.J., Barth R.N., Yamamoto S., et al. Activation of cytomegalovirus in pig-to-primate organ xenotransplantation. J. Virol. 76:2002;4734-4740
52. Gamble H.R., Andrews C.D., Dubey J.P., Webert D.W., Parmley S.F. Use of recombinant antigens for detection of Toxoplasma gondii infection in swine. J. Parsitol. 86:2000;459-462
53. Van Knapen F. Control of trichinellosis by inspection and farm management practices. Vet. Parasitol. 93:2000;385-392
54. Boneva R.S., Folks T.M., Chapman L.E. Infectious disease issues in xenotransplantation. Clin. Microbiol. Rev. 14:2001;1-14
55. Cunningham D.A., Herring C., Fernandez-Suarez X.M., Whittam A.J., Paradis K., Langford G.A. Analysis of patients with living pig tissue for evidence of infection by porcine endogenous retroviruses. Trends Cardiovasc. Med. 11:2001;190-196
56. Denning C., Burl S., Ainslie A., et al. Deletion of alpha (1, 3)galactosyl transferase (GGTA1) and prion protein (PrP) gene in sheep. Nat. Biotechnol. 19:2001;559-562