Production and characterization of a pig line transgenic for human membrane cofactor protein

Xenotransplantation

Volumn 9, Issue 3, 2002, Pages 183-190

  Zhou, Chun Yan ^a   McInnes, Elizabeth ^a   Parsons, Nicola ^a   Langford, Gillian ^a   Lancaster, Richard ^a   Richards, Andrew ^a   Pino Chavez, Gilda ^a   Dos Santos Cruz, Gabriela ^a   Copeman, Laura ^a   Carrington, Christine ^a   Thompson, Simon ^a  

^a Imutran Ltd   (United Kingdom)

Author keywords

Complement; Human membrane cofactor protein; Transgenic; Xenotransplantation

Indexed keywords

COMPLEMENT COMPONENT C3; DECAY ACCELERATING FACTOR; MEMBRANE COFACTOR PROTEIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOLYSIS; CYTOTOXICITY; ENDOTHELIUM CELL; GENE; HETEROZYGOSITY; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; NERVOUS TISSUE; NONHUMAN; PERIPHERAL LYMPHOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RIBONUCLEASE PROTECTION ASSAY; TRANSGENICS; XENOTRANSPLANTATION;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; ANTIBODIES, MONOCLONAL; ANTIGENS, CD; ANTIGENS, CD46; ANTIGENS, CD55; COMPLEMENT C3; CYTOTOXICITY TESTS, IMMUNOLOGIC; ENDOTHELIUM, VASCULAR; GENE EXPRESSION; GENETIC ENGINEERING; GRAFT REJECTION; HUMANS; MEMBRANE GLYCOPROTEINS; SWINE; TRANSPLANTATION, HETEROLOGOUS;

EID: 0036590317     PISSN: 0908665X     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1399-3089.2002.01034.x     Document Type: Article

References (30)

1. TUSO PJ, CRAMER DV, YASUNAGA C et al. Removal of natural human xenoantibodies to pig vascular endothelium by perfusion of blood through pigs kidneys and livers. Transplantation 1993; 55: 1375.
2. DALMASSO AP, VERCELLOTTI GM, FISCHEL RJ et al. Mechanism of complement activation in the hyperacute rejection of porcine organs transplanted into primate recipients. Am J Pathol 1992; 149: 1157.
3. CRUSE E, LEWIS RE. Complement Today. Complement Profiles, Vol. 1. Basel: Karger, 1993.
4. LISZEWSKI KM, POST TW, ATKINSON JP. Membrane cofactor protein (MCP or CD46): newest member of the regulators of complement activation gene cluster. Annu Rev Immunol 1991; 9: 431.
5. DAVIES A, LACHMANN PJ. Membrane defense against complement lysis: the structure and biological properties of CD59. Immunol Res 1993; 12: 258.
6. LANGFORD GL, YANNOUTSOS N, COZZI E et al. Production of pigs transgenic for human decay accelerating factor. Transplantation Proc 1994; 26: 1400.
7. FODOR WL, WILLIAMS BL, MATIS LS et al. Expression of functional human complement inhibitor in a transgenic pig as a model for the prevention of xenogeneic hyperacute organ rejection. Proc Natl Acad Sci USA 1994; 91: 11153.
8. SCHMOECKEL M, BHATTI FN, ZAIDI A et al. Orthotopic heart transplantation in a transgenic pig-to-primate model. Transplantation 1998; 65: 1570.
9. CHEN RH, NAFICY S, LOGAN JS, DIAMOND LE, ADAMS DH. Hearts from transgenic pigs constructed with CD59/DAF genomic clones demonstrate improved survival in primates. Xenotransplantation 1999; 6: 194.
10. LOSS M, PRZEMECK M, SCHMIDTKO J et al. Long-term survival of non-human primates receiving life-supporting transgenic porcine kidneys. Transplantation 2000; 32: 1095.
11. DIAMOND LE, QUINN CM, MARTIN MJ et al. A human CD46 transgenic pig model system for the study of discordant xenotransplantation. Transplantation 2001; 71: 132.
12. COZZI E, TUCKER AW, LANGFORD GA et al. Characterisation of pigs transgenic for human decay accelerating factor. Transplantation 1997; 64: 1383.
13. VELANDER WH, JOHNSON JL, PAGE RL et al. High-level expression of a heterologous protein in the milk of transgenic swine using the cDNA encoding human protein C. Proc Natl Acad Sci USA 1992; 89: 12003.
14. CARRINGTON CA, RICHARDS AC, TUCKER AW, PETERS AL, WHITE DJG. A line of transgenic pigs in which the expression of human decay-accelerating factor by endothelial cells is increased in the presence of inflammatory stimuli. Xenotransplantation 1996; 3: 87.
15. LACHMANN PJ, OLDROYD RG, MILSTEIN C, WRIGHT BW. Three rat monoclonal antibodies to human C3. Immunology 1980; 41: 503.
16. YANNOUTSOS N, IJZERMANS J, HARKES C et al. A Membrane cofactor protein transgenic mouse model for the study of hyperacute xenograft rejection. Genes Cells 1996; 1: 409.
17. COLE JL, HOUSLEY GA, DYKMAN TR, MACDERMOTT RP, ATKINSON JP. Identification of an additional class of C3binding membrane proteins of human peripheral blood leukocytes and cell lines. Proc Natl Acad Sci USA 1985; 82: 859.
18. ATKINSON JP, FARRIES T. Separation of self from non-self in the complement system. Immunol Today 1987; 8: 212.
19. HOLERS VM, COLE JL, LUBLIN DM, SEYA T, ATKINSON JP. Human C3b- and C4b-regulatory proteins: a new multigene family. Immunol Today 1985; 6: 188.
20. NANICHE D, VIRIOR-KRISHNAN G, CERVONI F. Human membrane cofactor protein (CD46) acts as a cellular receptor for measles virus. J Virol 1993; 67: 6025.
21. DORIG RE, MARCIL A, CHOPRA A, RICHARDSON CD. The human CD46 molecule is a receptor for measles virus (Edmonston strain). Cell 1993; 75: 295.
22. SCHNEIDER-SCHAULIES J, MAR3TIN MJ, LOGAN JS et al. CD46 transgene expression in pig peripheral blood mononuclear cells does not alter their susceptibility to measles virus or their capacity to downregulate endogenous and transgenic CD46. J Gen Virol 2000; 81: 1431.
23. BEGUM NA, MURAKAMI Y, MIKATA S et al. Molecular remodeling of human CD46 for xenotransplantation: designing a potent complement regulator without measles virus receptor activity. Immunology 2000; 100: 131.
24. ATKINSON JP, OGLESBY TJ, WHITE D, ADAMS EA, LISZEWSKI MK. Separation of self from non-self in the complement system: a role for membrane cofactor protein and decay accelerating factor. Clin Exp Immunol 1991; 86: 27.
25. LUBLIN DM, LISZEWSKI MK, POST TW et al. Molecular cloning and chromosomal localization of human membrane cofactor protein (MCP): evidence for inclusion in the multi-gene family of complement regulatory proteins. J Exp Med 1988; 168: 181.
26. THORLEY BR, MCINNES B, CHRISTIANSEN D, MCKENZIE IFC, LOVELAND BE. Construct of CD46 minigene for the production of transgenic mice. Transplantation Proc 1995; 27: 217.
27. OLDHAM ER, VELARDO MA, PLATT JL, LOGAN JS, DIAMOND L. High-level tissue specific expression of human CD59, MCP, and DAF proteins from genomic clones in transgenic mice. Transplantation Proc 1996; 28: 693.
28. LAZZERI M, MORA M, MULDER LC et al. Kidneys derived from mice transgenic for human complement blockers are protected in an in vivo model of hyperacute rejection. J Urol 1998; 159: 1364.
29. CARRINGTON CA, RICHARDS AC, COZZI E et al. Expression of human DAF and MCP on pig endothelial cells protects from human complement. Transplantation Proc 1995; 27: 321.
30. CARRINGTON CA, CRUZ G. Effect of cell surface concentration of human DAF on transgenic pig aortic endothelial cells on the degree of protection afforded against human complement deposition. Xenotransplantation 2001; 8: 100.