Blockage of HSP 90 modulates Helicobacter pylori-induced IL-8 productions through the inactivation of transcriptional factors of AP-1 and NF-κB

Biochemical and Biophysical Research Communications

Volumn 320, Issue 3, 2004, Pages 816-824

  Yeo, Marie ^a   Park, Hyun Kyung ^a   Lee, Ki Myung ^a   Lee, Kwang Jae ^a   Kim, Jin Hong ^a   Cho, Sung Won ^a   Hahm, Ki Baik ^a  

^a Ajou University School of Medicine   (South Korea)

Author keywords

Activator protein 1; Geldanamycin; Heat shock protein 90; Helicobacter pylori; IL 8; Nuclear factor B

Indexed keywords

GELDANAMYCIN; HEAT SHOCK PROTEIN 90; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 8; MITOGEN ACTIVATED PROTEIN KINASE 1; TRANSCRIPTION FACTOR AP 1;

ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; HELICOBACTER PYLORI; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM; STATISTICAL SIGNIFICANCE; STOMACH EPITHELIUM; TRANSCRIPTION INITIATION;

BENZOQUINONES; CELL LINE; GASTRIC MUCOSA; HELICOBACTER INFECTIONS; HELICOBACTER PYLORI; HSP90 HEAT-SHOCK PROTEINS; HUMANS; INTERLEUKIN-8; LACTAMS, MACROCYCLIC; NF-KAPPA B; QUINONES; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION FACTOR AP-1;

HELICOBACTER; HELICOBACTER PYLORI;

EID: 3042721493     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbrc.2004.05.214     Document Type: Article

References (44)

1. Kupper H., Adami H.O., Trichopoulos D. Infections as a major preventable cause of human cancer. J. Intern. Med. 248:2000;171-183
2. Shacter E., Weitzman S.A. Chronic inflammation and cancer. Oncology. 16:2002;217-226
3. Itzkowitz S. Colon carcinogenesis in inflammatory bowel diseases: applying molecular genetics to clinical practice. J. Clin. Gastroenterol. 36:2003;S70-S74
4. Blaser M.J., Chyou P.H., Nomura A. Age at establishment of Helicobacter pylori infection and gastric carcinoma, gastric ulcer, and duodenal ulcer risk. Cancer Res. 55:1995;562-565
5. Touati E., Michel V., Thiberge J.M., Wusher N., Huerre M., Labigne A. Chronic Helicobacter pylori infections induce gastric mutations in mice. Gastroenterology. 124:2003;1408-1419
6. Ebert M.P., Schandl L., Malfertheiner P. Helicobacter pylori infection and molecular changes in gastric carcinogenesis. J. Gastroenterol. 13:2002;45-49
7. Obst B., Wagner S., Sewing K.F., Beli W. Helicobacter pylori causes DNA damage in gastric epithelial cells. Carcinogenesis. 21:2000;1111-1115
8. Bagchi D., Bhattacharya G., Stohs S.J. Production of reactive oxygen species by gastric cells in association with Helicobacter pylori. Free Radic. Res. 24:1996;439-450
9. Moss S.F., Calam J., Agarwal B., et al. Induction of gastric epithelial apoptosis by Helicobacter pylori. Gut. 38:1996;498-501
10. Mannick E.E., Bravo L.E., Zarama G., et al. Inducible nitric oxide synthase, nitrotyrosine, and apoptosis in Helicobacter pylori gastritis: effect of antibiotics and antioxidants. Cancer Res. 56:1996;3238-3243
11. Brigati C., Noonan D.M., Albini A., Benelli R. Tumors and inflammatory infilterates: friends or foes? Clin. Exp. Metastasis. 19:2002;247-258
12. Torisu H., et al. Macrophage infiltration correlates with tumor stage and angiogenesis in human malignant melanoma: possible involvement of TNF-α and IL-1α Int. J. Cancer. 85:2000;182-188
13. Sunderkotter C., et al. Macrophages and angiogenesis. J. Leukoc. Biol. 55:1994;410-422
14. Yoshida S., et al. Involvement of interleukin-8, vascular endothelial growth factor, and basic fibroblast growth factor in tumor necrosis factor alpha-dependent angiogenesis. Mol. Cell. Biol. 17:1997;4015-4023
15. Morbidell L., Donnini S., Ziche M. Role of nitric oxide in the modulation of angiogenesis. Curr. Pharm. Des. 9:2003;521-530
16. Crabtree J.E., Peichl P., Wyatt J.I., Stachl U., Lindley I.J.D. Gastric interleukin-8 and IgA IL-8 autoantibodies in Helicobacter pylori infection. Scand. J. Immunol. 37:1993;65-70
17. Yamaoka Y., Kita M., Kodama T., Sawai N., Kashima K., Imanishi J. Induction of various cytokines and development of severe mucosal inflammation by cagA gene positive Helicobacter pylori strains. Gut. 41:1997;442-451
18. Baggiolini M., Dewald B., Moser B. Interleukin-8 and related chemotactic cytokines - CXC and CC chemokines. Adv. Immunol. 55:1994;167-179
19. Taub D.D., Oppenheim J.J. Chemokines, inflammation and the immune system. Ther. Immunol. 1:1994;229-246
20. Kido S., Kitadai Y., Hattori N., et al. Interleukin 8 and vascular endothelial growth factor - prognostic factors in human gastric carcinomas? Eur. J. Cancer. 37:2001;1482-1487
21. Kitadai Y., Haruma K., Sumii K., et al. Expression of interleukin-8 correlates with vascularity in human gastric carcinomas. Am. J. Pathol. 152:1998;93-100
22. Kitadai Y., Takahashi Y., Haruma K., et al. Transfection of interleukin-8 increases angiogenesis and tumorigenesis of human gastric carcinoma cells in nude mice. Br. J. Cancer. 81:1999;647-653
23. Zhu Y.M., Bradbury D.A., Pang L., et al. Transcriptional regulation of interleukin (IL)-8 by bradykinin in human airway smooth muscle cells involves prostanoid-dependent activation of AP-1 and nuclear factor (NF)-IL-6 and prostanoid-independent activation of NF-kappaB. J. Biol. Chem. 278:2003;29366-29375
24. Keates S., Hitti Y.S., Upton M., et al. Helicobacter pylori infection activates NF-kappa B in gastric epithelial cells. Gastroenterology. 113:1997;1099-1109
25. Sharma S.A., Tummuru M.K., Blaser M.J., et al. Activation of IL-8 gene expression by Helicobacter pylori is regulated by transcription factor nuclear factor-kappa B in gastric epithelial cells. J. Immunol. 160:1998;2401-2407
26. Keates S., Keates A.C., Warny M., et al. Differential activation of mitogen-activated protein kinases in AGS gastric epithelial cells by cag+ and cag- Helicobacter pylori. J. Immunol. 163:1999;5552-5559
27. Kumar A., Knox K.A.J., Boriek A.M., et al. CCAAT/enhancer-binding protein and activator protein-1 transcription factors regulate the expression of interleukin-8 through the mitogen-activated protein kinase pathways in response to mechanical stretch of human airway smooth muscle cells. J. Biol. Chem. 278:2003;18868-18876
28. Richter K., Buchner J. Hsp90: chaperoning signal transduction. J. Cell Physiol. 188:2001;281-290
29. Pratt W.B., Toft D.O. Regulation of signaling protein function and trafficking by the hsp90/hsp70-based chaperone machinery. Exp. Biol. Med. (Maywood). 228:2003;111-133
30. Sharma S.V., Agatsuma T., Nakano H., et al. Targeting of the protein chaperone, HSP90, by the transformation suppressing agent, radicicol. Oncogene. 16:1998;2639-2645
31. Stebbins C.E., Russo A.A., Schneider C., et al. Crystal structure of an Hsp90-geldanamycin complex: targeting of a protein chaperone by an antitumor agent. Cell. 89:1997;239-250
32. Prodromou C., Roe S.M., O'Brien R., et al. Identification and structural characterization of the ATP/ADP-binding site in the Hsp90 molecular chaperone. Cell. 90:1997;65-75
33. Supko J.G., Hickman R.L., Grever M.R., et al. Preclinical pharmacologic evaluation of geldanamycin as an antitumor agent. Cancer Chemother. Pharmacol. 36:1995;305-315
34. Neckers L. Hsp90 inhibitors as novel cancer chemotherapeutic agents. Trends Mol. Med. 8:2002;S55-61
35. Malhotra V., Shanley T.P., Pittet J.F., et al. Geldanamycin inhibits NF-kappaB activation and interleukin-8 gene expression in cultured human respiratory epithelium. Am. J. Respir. Cell Mol. Biol. 25:2001;92-97
36. Byrd C.A., Bornmann W., Erdjument-Bromage H., et al. Heat shock protein 90 mediates macrophage activation by Taxol and bacterial lipopolysaccharide. Proc. Natl. Acad. Sci. USA. 96:1999;5645-5650
37. Zhu F.G., Pisetsky D.S. Role of the heat shock protein 90 in immune response stimulation by bacterial DNA and synthetic oligonucleotides. Infect. Immun. 69:2001;5546-5552
38. Bendre M.S., Gaddy-Kurten D., Mon-Foote T., et al. Expression of interleukin 8 and not parathyroid hormone-related protein by human breast cancer cells correlates with bone metastasis in vivo. Cancer Res. 62:2002;5571-5579
39. Kumar Y., Tatu U. Stress protein flux during recovery from simulated ischemia: induced heat shock protein 70 confers cytoprotection by suppressing JNK activation and inhibiting apoptotic cell death. Proteomics. 3:2003;513-526
40. Huang S., Mills L., Mian B., et al. Fully humanized neutralizing antibodies to interleukin-8 (ABX-IL8) inhibit angiogenesis, tumor growth, and metastasis of human melanoma. Am. J. Pathol. 161:2002;125-134
41. Barshishat M., Ariel A., Cahalon L., et al. TNFalpha and IL-8 regulate the expression and function of CD44 variant proteins in human colon carcinoma cells. Clin. Exp. Metastasis. 19:2002;327-337
42. 2-terminal threonine residues. J. Biol. Chem. 264:1989;17275-17280
43. Lees-Miller S.P., Anderson C.W. Two human 90-kDa heat shock proteins are phosphorylated in vivo at conserved serines that are phosphorylated in vitro by casein kinase II. J. Biol. Chem. 264:1989;2431-2437
44. Adinolfi E., Kim M., Young M.T., et al. Tyrosine phosphorylation of HSP90 within the P2X7 receptor complex negatively regulates P2X7 receptors. J. Biol. Chem. 278:2003;37344-37351