Colon carcinogenesis in inflammatory bowel disease: Applying molecular genetics to clinical practice

Journal of Clinical Gastroenterology

Volumn 36, Issue 5 SUPPL., 2003, Pages

  Itzkowitz, Steven ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

Colon carcinogenesis; Inflammatory bowel disease; Sporadic colorectal cancer

Indexed keywords

ANTIGEN; CANCER GROWTH FACTOR; KI 67 ANTIGEN; MOLECULAR MARKER; MUCIN; PROTEIN MLH1; PROTEIN P53;

ANEUPLOIDY; ANTIGEN EXPRESSION; CANCER EPIDEMIOLOGY; CANCER RISK; CHROMOSOME ABERRATION; COLON CARCINOGENESIS; COLON CARCINOMA; COLONOSCOPY; COLORECTAL CANCER; CONFERENCE PAPER; CROHN DISEASE; DIFFERENTIAL DIAGNOSIS; DISEASE ASSOCIATION; DYSPLASIA; ENTERITIS; FECES ANALYSIS; GENE EXPRESSION; HISTOLOGY; HUMAN; MICROSATELLITE INSTABILITY; MOLECULAR DYNAMICS; ONCOGENE K RAS; PRIORITY JOURNAL; PROTEIN EXPRESSION; SINGLE NUCLEOTIDE POLYMORPHISM; ULCERATIVE COLITIS;

COLONIC NEOPLASMS; DISEASE PROGRESSION; HUMANS; INFLAMMATORY BOWEL DISEASES; MOLECULAR BIOLOGY; TUMOR MARKERS, BIOLOGICAL;

EID: 0037404387     PISSN: 01920790     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004836-200305001-00012     Document Type: Conference Paper

References (35)

1. Sachar DB. Cancer in Crohn's disease: Dispelling the myths. Gut 1994;35:1507-8.
2. Chung DC. The genetic basis of colorectal cancer: Insights into critical pathways of tumorigenesis. Gastroenterology 2000;119:854-65.
3. Calvert PM, Frucht H. The genetics of colorectal cancer. Ann Intern Med 2002;137:603-12.
4. Willenbucher RF, Aust DE, Chang CG, et al. Genomic instability is an early event during the progression pathway of ulcerative colitis-related neoplasia. Am J Pathol 1999;154:1825-30.
5. Suzuki H, Harpaz N, Tarmin L, et al. Microsatellite instability in ulcerative colitis-associated colorectal dysplasias and cancers. Cancer Res 1994;54:4841-4.
6. Tarmin L, Yin J, Harpaz N, et al. Adenomatous polyposis coli gene mutations in ulcerative colitis-associated dysplasias and cancers versus sporadic colon neoplasms. Cancer Res 1995;55:2035-8.
7. Redston MS, Papadopoulos N, Caldas C, et al. Common occurrence of APC and K-ras gene mutations in the spectrum of colitis-associated neoplasias. Gastroenterology 1995;108:383-92.
8. Aust DE, Terdiman JP, Willenbucher RF, et al. The APC/β-catenin pathway in ulcerative colitis-related colorectal carcinomas. Cancer 2002;94:1421-7.
9. Burmer GC, Rabinovitch PS, Haggitt RC, et al. Neoplastic progression in ulcerative colitis: Histology. DNA content, and loss of a p53 allele. Gastroenterology 1992;103:1602-10.
10. , Brentnall TA, Crispin DA, Rabinovitch PS, et al. Mutations of the p53 gene: An early marker of neoplastic progression in ulcerative colitis. Gastroenterology 1994;107:369-78.
11. Klump B, Holzmann K, Kuhn A, et al. Distribution of cell populations with DNA aneuploidy and p53 protein expression in ulcerative colitis. Eur J Gastroenterol Hepatol 1997;9:789-94.
12. Yin J, Harpaz N, Tong Y, et al. p53 mutations in dysplastic and cancerous ulcerative colitis lesions. Gastroenterology 1993;104:1633-9.
13. Brentnall TA, Crispin DA, Bronner MP, et al. Microsatellite instability in nonneoplastic mucosa from patients with chronic ulcerative colitis. Cancer Res 1996;56:1237-40.
14. Heinen CD, Noffsinger AE, Belli J, et al. Regenerative lesions in ulcerative colitis are characterized by microsatellite mutation. Genes Chromosomes Cancer 1997;19:170-5.
15. Fleisher AS, Esteller M, Harpaz N, et al. Microsatellite instability in inflammatory bowel disease-associated neoplastic lesions is associated with hypermethylation and diminished expression of the DNA mismatch repair gene, hMLH1. Cancer Res 2000;60:4864-8.
16. Hsieh CJ, Klump B, Holzmann K, et al. Hypermethylation of the p16INK4a promoter in colectomy specimens of patients with long-standing and extensive ulcerative colitis. Cancer Res 1998;58:3942-45.
17. Issa JPJ, Ahuja N, Toyota M, et al. Accelerated age-related CpG island methylation in ulcerative colitis. Cancer Res 2001;61:3573-7.
18. Hussain SP, Amstad P, Raja K, et al. Increased p53 mutation load in noncancerous colon tissue from ulcerative colitis: A cancer-prone chronic inflammatory bowel disease. Cancer Res 2000;60:3333-7.
19. Chang CL, Marra G, Chauhan DP, et al. Oxidative stress inactivates the human DNA mismatch repair system. Am J Physiol Cell Physiol 2002;283:C148-54.
20. Agoff SN, Brentnall TA, Crispin DA, et al. The role of cyclooxygenase 2 in ulcerative colitis-associated neoplasia. Am J Pathol 2000;157:737-45.
21. Hisamatsu T, Watanabe M, Ogata H, et al. Interferon-inducible gene family 1-8U expression in colitis-associated colon cancer and severely inflamed mucosa in ulcerative colitis. Cancer Res 1999;59:5927-31.
22. Lindberg JO, Stenling RB, Rutegard JN. DNA aneuploidy as a marker of premalignancy in surveillance of patients with ulcerative colitis. Br J Surg 1999;86:947-50.
23. Lofberg R, Brostrom O, Karlen P, et al. DNA aneuploidy in ulcerative colitis: Reproducibility, topographic distribution, and relation to dysplasia. Gastroenterology 1992;102:1149-54.
24. Rubin CE, Haggitt RC, Burmer GC, et al. DNA aneuploidy in colonic biopsies predicts future development of dysplasia in ulcerative colitis. Gastroenterology 1992;103:1611-20.
25. Befrits R, Hammarberg C, Rubio C, et al. DNA aneuploidy and histologic dysplasia in long-standing ulcerative colitis: A 10-year follow-up study. Dis Colon Rectum 1994;37:313-20.
26. Lashner BA, Shapiro BD, Husain A, et al. Evaluation of the usefulness of testing for p53 mutations in colorectal cancer surveillance for ulcerative colitis. Am J Gastroenterol 1999;94:456-62.
27. Sato A, Machinami R. p53 immunohistochemistry of ulcerative colitis associated with dysplasia and carcinoma. Pathol Int 1999;49:858-68.
28. Itzkowitz SH, Young E, Dubois D, et al. Sialosyl-Tn antigen is prevalent and precede dysplasia in ulcerative colitis: A retrospective case-control study. Gastroenterology 1996;110:694-704.
29. Karlen P, Young E, Brostrom O, et al. Sialyl-Tn antigen as a marker of colon cancer risk in ulcerative colitis: Relation to dysplasia and DNA aneuploidy. Gastroenterology 1998;115:1395-404.
30. Rubin PH, Friedman S, Harpaz S, et al. Colonoscopic polypectomy in chronic colitis: Conservative management after endoscopic resection of dysplastic polyps. Gastroenterology 1999;117:1295-300.
31. Engelsgjerd M, Farraye FA, Odze RD. Polypectomy may be adequate treatment of adenoma-like dysplastic lesions in chronic ulcerative colitis. Gastroenterology 1999;117:1288-94.
32. Odze RD, Brown CA, Hartmann CJ, et al. Genetic alterations in chronic ulcerative colitis-associated adenoma-like DALMs are similar to non-colitic sporadic adenomas. Am J Surg Pathol 2000;24:1209-16.
33. Selaru FM, Xu Y, Yin J, et al. Artificial neural networks distinguish among subtypes of neoplastic colorectal lesions. Gastroenterology 2002;122:606-13.
34. Uthoff SMS, Hilliard D, Eichenberger M, et al. Significance of the wnt-pathway for cancer risk in inflammatory bowel disease: Association of a genetic polymorphism in human disheveled I with dysplasia in ulcerative colitis. Gastroenterology 2002;122:A104.
35. Ahlquist DA, Skoletsky JE, Boynton KA, et al. Colorectal cancer screening by detection of altered human DNA in stool: Feasibility of a multitarget assay panel. Gastroenterology 2000;119:1219-27.