Definitive evidence for Ufd2-catalyzed elongation of the ubiquitin chain through Lys48 linkage

Biochemical and Biophysical Research Communications

Volumn 320, Issue 3, 2004, Pages 840-845

  Saeki, Yasushi ^a,b   Tayama, Yoko ^a   Toh e, Akio ^b   Yokosawa, Hideyoshi ^a  

^a HOKKAIDO UNIVERSITY   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

Author keywords

Mass spectrometry; Proteolysis; Ubiquitin; Ubiquitin fusion degradation; Ubiquitinating enzyme; Ufd2

Indexed keywords

ELONGATION FACTOR; LYSINE; UFD2 PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; ENZYME ACTIVITY; ENZYME RECONSTITUTION; GENETIC LINKAGE; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; NONHUMAN; PRIORITY JOURNAL; PROTEIN PURIFICATION; SACCHAROMYCES CEREVISIAE; UBIQUITINATION; YEAST;

BINDING SITES; CATALYSIS; LYSINE; PROTEIN BINDING; PROTEIN CONFORMATION; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SIGNAL TRANSDUCTION; STRUCTURE-ACTIVITY RELATIONSHIP; UBIQUITIN; UBIQUITIN-CONJUGATING ENZYMES;

MAMMALIA; SACCHAROMYCES; SACCHAROMYCES CEREVISIAE;

EID: 3042719644     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbrc.2004.05.216     Document Type: Article

References (18)

1. Hershko A., Ciechanover A. The ubiquitin system. Annu. Rev. Biochem. 67:1998;425-479
2. Glickman M.H., Ciechanover A. The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction. Physiol. Rev. 82:2002;373-428
3. Koegl M., Hoppe T., Schlenker S., Ulrich H.D., Mayer T.U., Jentsch S. A novel ubiquitination factor, E4, is involved in multiubiquitin chain assembly. Cell. 96:1999;635-644
4. Hicke L. Protein regulation by monoubiquitin. Nat. Rev. Mol. Cell Biol. 2:2001;195-201
5. Johnson E.S., Ma P.C., Ota I.M., Varshavsky A. A proteolytic pathway that recognizes ubiquitin as a degradation signal. J. Biol. Chem. 270:1995;17442-17456
6. Hatakeyama S., Yada M., Matsumoto M., Ishida N., Nakayama K.I. U box proteins as a new family of ubiquitin-protein ligases. J. Biol. Chem. 276:2001;33111-33120
7. Saeki Y., Sone T., Toh-e A., Yokosawa H. Identification of ubiquitin-like protein-binding subunits of the 26S proteasome. Biochem. Biophys. Res. Commun. 296:2002;813-819
8. Hofmann R.M., Pickart C.M. Noncanonical MMS2-encoded ubiquitin- conjugating enzyme functions in assembly of novel polyubiquitin chains for DNA repair. Cell. 96:1999;645-653
9. Sone T., Saeki Y., Toh-e A., Yokosawa H. Sem1p is a novel subunit of the 26S proteasome from Saccharomyces cerevisiae. J. Biol. Chem. 279:2004;28807-28816
10. Braun S., Matuschewski K., Rape M., Thoms S., Jentsch S. Role of the ubiquitin-selective CDC48 (UFD1/NPL4) chaperone (segregase) in ERAD of OLE1 and other substrates. EMBO J. 21:2002;615-621
11. Meyer H.H., Shorter J.G., Seemann J., Pappin D., Warren G. A complex of mammalian ufd1 and npl4 links the AAA-ATPase, p97, to ubiquitin and nuclear transport pathways. EMBO J. 19:2000;2181-2192
12. Brunger A.T., DeLaBarre B. NSF and p97/VCP: similar at first, different at last. FEBS Lett. 555:2003;126-133
13. Xie Y., Varshavsky A. UFD4 lacking the proteasome-binding region catalyses ubiquitination but is impaired in proteolysis. Nat. Cell Biol. 4:2002;1003-1007
14. Salvat C., Wang G., Dastur A., Lyon N., Huibregtse J.M. The-4 phenylalanine is required for substrate ubiquitination catalyzed by HECT ubiquitin ligases. J. Biol. Chem. 279:2004;18935-18943
15. Peng J., Schwartz D., Elias J.E., Thoreen C.C., Cheng D., Marsischky G., Roelofs J., Finley D., Gygi S.P. A proteomics approach to understanding protein ubiquitination. Nat. Biotechnol. 21:2003;921-926
16. Rao H., Sastry A. Recognition of specific ubiquitin conjugates is important for the proteolytic functions of the ubiquitin-associated domain proteins Dsk2 and Rad23. J. Biol. Chem. 277:2002;11691-11695
17. You J., Pickart C.M. A HECT domain E3 enzyme assembles novel polyubiquitin chains. J. Biol. Chem. 276:2001;19871-19878
18. Nishikawa H., Ooka S., Sato K., Arima K., Okamoto J., Klevit R.E., Fukuda M., Ohta T. Mass spectrometric and mutational analyses reveal Lys-6-linked polyubiquitin chains catalyzed by BRCA1-BARD1 ubiquitin ligase. J. Biol. Chem. 279:2004;3916-3924