Akt kinases and 2-deoxyglucose uptake in rat skeletal muscles in vivo: Study with insulin and exercise

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 276, Issue 1 45-1, 1999, Pages

  Turinsky, Jiri ^a   Damrau Abney, Alice ^a  

^a ALBANY MEDICAL COLLEGE   (United States)

Author keywords

Fast twitch muscle; Plantaris muscle; Protein kinase B isoforms; Slow twitch muscle; Soleus muscle

Indexed keywords

DEOXYGLUCOSE; INSULIN; PHOSPHOTRANSFERASE; PROTEIN KINASE B;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; EXERCISE; IMMUNOPRECIPITATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SKELETAL MUSCLE;

EID: 0032891637     PISSN: 03636119     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpregu.1999.276.1.r277     Document Type: Article

References (31)

1. Alessi, D. R., M. Andjelkovic, F. B. Caudwell, P. Cron, N. Morrice, P. Cohen, and B. A. Hemmings. Mechanism of activation of protein kinase B by insulin and IGF-1. EMBO J. 15: 6541-6551, 1996.
2. Alessi, D. R., S. R. James, C. P. Downes, A. B. Holmes, P. J. Gaffney, C. B. Reese, and P. Cohen. Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Ba. Curr. Biol. 7: 261-269, 1997.
3. Ariano, M. A., R. B. Armstrong, V. R. Edgerton. Hindlimb muscle fiber populations of five mammals. J. Histochem. Cytochem. 21: 51-55, 1973.
4. Baron, A. D., G. Brechtel, P. Wallace, and S. V. Edelman. Rates and tissue sites of non-insulin and insulin-mediated glucose uptake in human. Am. J. Physiol. 255 (Endocrinol. Metab. 18): E769-E774, 1988.
5. Brozinick, J. T., Jr., and M. J. Birnbaum. Insulin, but not contraction, activates Akt/PKB in isolated rat skeletal muscle. J. Biol. Chem. 273: 14679-14682, 1998.
6. Cartee, G. D., A. G. Doven, T. Ramlal, A. Klip, and J. O. Holloszy. Stimulation of glucose transport in skeletal muscle by hypoxia. J. Appl. Physiol. 70: 1593-1600, 1991.
7. Cheatham, B., and C. R. Kahn. Insulin action and the insulin signaling network. Endocr. Rev. 16: 117-142, 1995.
8. Cheng, J. Q., A. K. Godwin, A. Bellacosa, T. Taguchi, T. F. Franke, T. C. Hamilton, P. N. Tsichlis, and J. R. Testa. Akt2, a putative oncogene encoding a member of a subfamily of protein-serine/threonine kinases, is amplified in human ovarian carcinomas. Proc. Natl. Acad. Sci. USA 89: 9267-9271, 1992.
9. Coffer, P. J., and J. R. Woodgett. Molecular cloning and characterization of a novel putative protein-serine kinase related to the cAMP-dependent and protein kinase C families. Eur. J. Biochem. 201: 475-481, 1991.
10. Cohen, P., D. R. Alessi, and D. A. E. Cross. PDK1, one of the missing links in insulin signal transduction. FEBS Lett. 410: 3-10, 1997.
11. Cong, L.-N., H. Chen, Y. Li, L. Zhou, M. A. McGibbon, S. I. Taylor, and M. J. Quon. Physiological role of Akt in insulin-stimulated translocation of GLUT4 in transfected rat adipose cells. Mol. Endocrinol. 11: 1881-1890, 1997.
12. Cross, D. A. E., P. W. Watt, M. Shaw, J. van der Kaay, C. P. Downes, J. C. Holder, and P. Cohen. Insulin activates protein kinase B, inhibits glycogen synthase kinase-3 and activates glycogen synthase by rapamycin-insensitive pathways in skeletal muscle and adipose tissue. FEBS Lett. 406: 211-215, 1997.
13. Datta, S. R., H. Dudek, X. Tao, S. Masters, H. Fu, Y. Gotoh, and M. E. Greenberg. Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell 91: 231-241, 1997.
14. DeFronzo, R. A., E. Jacot, E. Jequier, E. Maeder, J. Wahren, and J. P. Felber. The effect of insulin on the disposal of intravenous glucose: results from indirect calorimetry and hepatic and femoral venous catheterization. Diabetes 30: 1000-1007, 1981.
15. Elmendorf, J. S., A. Damrau-Abney, T. R. Smith, T. S. David, and J. Turinsky. Insulin-stimulated phosphatidylinositol 3-kinase activity and 2-deoxy-D-glucose uptake in rat skeletal muscles. Biochem. Biophys. Res. Commun. 208: 1147-1153, 1995.
16. Elmendorf, J. S., A. Damrau-Abney, T. R. Smith, T. S. David, and J. Turinsky. Phosphatidylinositol 3-kinase and the dynamics of insulin resistance in denervated slow and fast muscles in vivo. Am. J. Physiol. 272 (Endocrinol. Metab. 35): E661-E670, 1997.
17. Haruta, T., A. J. Morris, D. W. Rose, J. G. Nelson, M. Mueckler, and J. M. Olefsky. Insulin-stimulated GLUT-4 translocation is mediated by a divergent intracellular signaling pathway. J. Blol. Chem. 270: 27991-27994, 1995.
18. 2+. J. Gen. Physiol. 50: 551-562, 1967.
19. Kohn, A. D., S.A. Summers, M. J. Birnbaum, and R.A. Roth. Expression of constitutively active Akt Ser/Thr kinase in 3T3-L1 adipocytes stimulates glucose uptake and glucose transporter 4 translocation. J. Biol. Chem. 271: 31372-31378, 1996.
20. Konishi, H., S. Kuroda, M. Tanaka, H. Matsuzaki, Y. Ono, K. Kameyama, T. Haga, and U. Kikkawa. Molecular cloning and characterization of a new member of the RAC protein kinase family: association of the pleckstrin homology domain of three types of RAC protein kinase with protein kinase C subspecies and βγ subunits of G proteins. Biochem. Biophys. Res. Commun. 216: 526-534, 1995.
21. Konishi, H., H. Matsuzaki, M. Tanaka, Y. Ono, C. Tokunaga, S. Kuroda, and U. Kikkawa. Activation of RAC-protein kinase by heat shock and hyperosmolarity stress through a pathway independent of phosphatidylinositol 3-kinase. Proc. Natl. Acad. Sci. USA 93: 7639-7643, 1996.
22. Moule, S. K., G. I. Welsh, N. J. Edgell, E. J. Foulstone, C. G. Proud, and R. M. Denton. Regulation of protein kinase B and glycogen synthase kinase 3 by insulin and β-adrenergic agonists in rat epididymal fat cells. J. Biol. Chem. 272: 7713-7719, 1997.
23. Okada, T., Y. Kawano, T. Sakakibara, O. Hazeki, and U. Michio. Essential role of phosphatidylinositol 3-kinase in insulin-induced glucose transport and antilipolysis in rat adipocytes: studies with a selective inhibitor wortmannin. J. Biol. Chem. 269: 3568-3573, 1994.
24. Sable, C. L., N. Filippa, B. Hemmings, and E. VanObberghen. cAMP stimulates protein kinase B in a wortmannin-insensitive manner. FEBS Lett. 409: 253-257, 1997.
25. Sanchez-Margalet, V., I. D. Goldfine, C. J. Vlahos, and C. K. Sung. Role of phosphatidylinositol-3-kinase in insulin receptor signaling: studies with inhibitor, LY294002. Biochem. Biophys. Res. Commun. 204: 446-452, 1994.
26. Tanti, J. F., S. Grille, T. Cremeaux, P. J. Coffer, E. VanObberghen, and Y. LeMarchand-Brustel. Potential role of protein kinase B in glucose transporter translocation in adipocytes. Endocrinology 138: 2005-2010, 1997.
27. Turinsky, J. Glucose and amino acid uptake by exercising muscles in vivo. Effect of insulin, fiber population, and denervation. Endocrinology 121: 528-535, 1987.
28. Turinsky, J. Dynamics of insulin resistance in denervated slow and fast muscles in vivo. Am. J. Physiol. 252 (Regulatory Integrative Comp. Physiol. 21): R531-R537, 1987.
29. Turinsky, J., B. P. Bayly, and D. M. O'Sullivan. 1,2-Diacylglycerol and ceramide levels in rat skeletal muscle and liver in vivo. Studies with insulin, exercise, muscle denervation, and vasopressin. J. Biol. Chem. 265: 7933-7938, 1990.
30. Yeh, J.-I., E. A. Gulve, L. Rameh, and M. J. Birnbaum. The effects of wortmannin on rat skeletal muscle: dissociation of signaling pathways for insulin- and contraction-activated hexose transport. J. Biol. Chem. 270: 2107-2111, 1995.
31. Walker, K. S., M. Deak, A. Paterson, K. Hudson, P. Cohen, and D. R. Alessi. Activation of protein kinase Bβ and γ isoforms by insulin in vivo and by 3-phosphoinositide-dependent protein kinase-1 in vitro: comparison with protein kinase Bα. Biochem. J. 331: 299-308, 1998.