Isoproterenol exacerbates a long QT phenotype in Kcnq1-deficient neonatal mice: Possible roles for human-like Kcnq1 isoform 1 and slow delayed rectifier K+ current

Journal of Pharmacology and Experimental Therapeutics

Volumn 310, Issue 1, 2004, Pages 311-318

  Knollmann, Bjorn C ^a   Casimiro, Mathew C ^b   Katchman, Alexander N ^a   Sirenko, Syevda G ^a   Schober, Tilmann ^a   Rong, Qi ^a   Pfeifer, Karl ^b   Ebert, Steven N ^a  

^a GEORGETOWN UNIVERSITY MEDICAL CENTER   (United States)

^b EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA ADRENERGIC RECEPTOR STIMULATING AGENT; ISOPRENALINE; L 735821; POTASSIUM CHANNEL KCNQ1; UNCLASSIFIED DRUG;

ACTION POTENTIAL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BETA ADRENERGIC STIMULATION; CONTROLLED STUDY; ELECTROCARDIOGRAM; GENE; GENE DISRUPTION; GENE MUTATION; HEART MUSCLE CELL; KCNQ1 GENE; KNOCKOUT MOUSE; LONG QT SYNDROME; MOUSE; MOUSE STRAIN; MUSCLE CELL; NEWBORN; NONHUMAN; NUCLEOTIDE SEQUENCE; PATCH CLAMP; PHENOTYPE; POTASSIUM CURRENT; PRIORITY JOURNAL; QT INTERVAL; SEQUENCE HOMOLOGY; SLOW DELAYED RECTIFIER POTASIUM CURRENT; VOLTAGE CLAMP;

ACTION POTENTIALS; ADRENERGIC BETA-AGONISTS; AMINO ACID SEQUENCE; ANIMALS; DELAYED RECTIFIER POTASSIUM CHANNELS; HUMANS; ISOPROTERENOL; KCNQ POTASSIUM CHANNELS; KCNQ1 POTASSIUM CHANNEL; LONG QT SYNDROME; MICE; MICE, KNOCKOUT; MOLECULAR SEQUENCE DATA; PHENOTYPE; POTASSIUM CHANNELS; POTASSIUM CHANNELS, VOLTAGE-GATED; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 3042597449     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.103.063743     Document Type: Article

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