4-Hydroxymethyl-3-aminoacridine derivatives as a new family of anticancer agents

Journal of Medicinal Chemistry

Volumn 46, Issue 6, 2003, Pages 967-977

  Charmantray, Franck ^a   Demeunynck, Martine ^a   Carrez, Danièle ^b   Croisy, Alain ^b   Lansiaux, Amélie ^c   Bailly, Christian ^c   Colson, Pierre ^d  

^a UNIVERSITÉ JOSEPH FOURIER   (France)

^b INSTITUT CURIE   (France)

^c INSERM   (France)

^d UNIVERSITY OF LIÈGE   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

3 AMINOACRIDINE; 4 HYDROXYMETHYL 3 AMINOACRIDINE DERIVATIVE; 6 ETHOXYCARBONYLAMINO 4 HYDROXYMETHYL 3 AMINOACRIDINE; ACRIDINE DERIVATIVE; ANTINEOPLASTIC AGENT; CELL DNA; DIHYDROOXAZINOACRIDINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CELL GRANULE; CELL NUCLEUS; COLON CANCER; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOPLASM; CYTOTOXICITY; DRUG ACTIVITY; DRUG DISTRIBUTION; DRUG MECHANISM; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; HUMAN; HUMAN CELL; LUNG CANCER; MOUSE; MURINE LEUKEMIA; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ACRIDINES; AMINOACRIDINES; ANIMALS; ANTINEOPLASTIC AGENTS; CARBAMATES; DNA; DNA TOPOISOMERASES, TYPE I; DNA TOPOISOMERASES, TYPE II; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; INTERCALATING AGENTS; MICE; MICROSCOPY, CONFOCAL; STRUCTURE-ACTIVITY RELATIONSHIP; SUBCELLULAR FRACTIONS; TUMOR CELLS, CULTURED;

EID: 0037435059     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm020389w     Document Type: Article

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