Substitutions at methionine 220 in the 14α-sterol demethylase (cyp51A) of Aspergillus fumigatus are responsible for resistance in vitro to azole antifungal drugs

Antimicrobial Agents and Chemotherapy

Volumn 48, Issue 7, 2004, Pages 2747-2750

  Mellado, E ^a   Garcia Effron, G ^a   Alcazar Fuoli, L ^a   Cuenca Estrella, M ^a   Rodriguez Tudela, J L ^a  

^a INSTITUTO DE SALUD CARLOS III   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIFUNGAL AGENT; ERGOSTEROL; FLUCONAZOLE; FUNGAL ENZYME; ITRACONAZOLE; LYSINE; METHIONINE; POSACONAZOLE; PYRROLE DERIVATIVE; STEROL 14ALPHA DEMETHYLASE; THREONINE; TRIAZOLE DERIVATIVE; UNCLASSIFIED DRUG; VALINE; VORICONAZOLE;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; ASPERGILLUS FUMIGATUS; CONTROLLED STUDY; CYP51A GENE; CYP51B GENE; ENZYME ACTIVITY; FUNGAL GENE; FUNGAL STRAIN; FUNGUS ISOLATION; GENE FUNCTION; GENE INSERTION; GENE LOCATION; GENE MUTATION; IN VITRO STUDY; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPE; POINT MUTATION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SEQUENCE ALIGNMENT; SEQUENCE ANALYSIS; WILD TYPE;

ALLELES; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANTIFUNGAL AGENTS; ASPERGILLUS FUMIGATUS; AZOLES; CYTOCHROME P-450 ENZYME SYSTEM; DRUG RESISTANCE, FUNGAL; FUNGAL PROTEINS; METHIONINE; MICROBIAL SENSITIVITY TESTS; MOLECULAR SEQUENCE DATA; MUTATION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 3042531281     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.48.7.2747-2750.2004     Document Type: Article

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