Stochastic entropy QSAR for the in silico discovery of anticancer compounds: Prediction, synthesis, and in vitro assay of new purine carbanucleosides

Bioorganic and Medicinal Chemistry

Volumn 14, Issue 4, 2006, Pages 1095-1107

  González Díaz, Humberto ^a,b   Viña, Dolores ^b,c   Santana, Lourdes ^b   De Clercq, Erik ^d   Uriarte, Eugenio ^b  

^a CENTRAL UNIVERSITY OF LAS VILLAS   (Cuba)

^b UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

^c UNIVERSITY OF SALAMANCA   (Spain)

^d REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

Author keywords

Anti cancer compounds; Leukemia; Markov model; Nucleoside; QSAR

Indexed keywords

2 AMINE 8 AZA 6 CHLORO 9 [2 (HYDROXYMETHYL)CYCLOHEXYL] 9H PURINE; 2,6 DIAMINO 8 AZA 9 [2 (HYDROXYMETHYL)CYCLOHEXYL]PURINE; 2,6 DIAMINO 9 [2 (HYDROXYMETHYL)CYCLOHEXYL] PURINE; 8 AZA 9 [(2 HYROXYMETHYL)CYCLOHEXYL]GUANINE; 9 [2 (HYDROXYMETHYL)CYCLOHEXYL]GUANINE; ACODAZOLE; ANTINEOPLASTIC AGENT; ATROPINE METHYL NITRATE; AZACITIDINE; BENFLURON; BUSULFAN; CAMPTOTHECIN; CARBOQUONE; CYTARAZID; ECHINOSPORIN; ELMUSTINE; FEBRIFUGINE; LAPACHOL; MITOGUAZONE; MITOLACTOL; PUMITEPA; PURINE DERIVATIVE; SANGIVAMYCIN; SPIRAZIDINE; SPIROPLATIN; TEPA; TRIAZIQUONE; UNCLASSIFIED DRUG; UNINDEXED DRUG; URAMUSTINE; VIDARABINE;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; DRUG SCREENING; DRUG SYNTHESIS; ENTROPY; HUMAN; HUMAN CELL; IN VITRO STUDY; LEUKEMIA CELL; MOUSE; NONHUMAN; PREDICTION; QUANTITATIVE STRUCTURE ACTIVITY RELATION; SENSITIVITY AND SPECIFICITY; T LYMPHOCYTE; VALIDATION PROCESS;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; COMPUTATIONAL BIOLOGY; DRUG EVALUATION, PRECLINICAL; ENTROPY; HUMANS; MICE; MOLECULAR STRUCTURE; NUCLEOSIDES; PURINES; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; STOCHASTIC PROCESSES;

ANIMALIA; ARA; MURINAE;

EID: 30344455624     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2005.09.039     Document Type: Article

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