Allosteric positive interaction of thymol with the GABAA receptor in primary cultures of mouse cortical neurons

Neuropharmacology

Volumn 50, Issue 1, 2006, Pages 25-35

  García, Daniel A ^a   Bujons, Jordi ^b   Vale, Carmen ^a,c   Suñol, Cristina ^a  

^a INSTITUT D INVESTIGACIONS BIOMÈDIQUES AUGUST PI I SUNYER IDIBAPS   (Spain)

^b DEPARTMENT OF ENVIRONMENTAL CHEMISTRY   (Spain)

^c UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

Author keywords

Cell viability; Cultured cortical neurons; GABAA receptor; Pharmacophore model; Receptor binding and chloride flux; Thymol

Indexed keywords

3 AMINO 2 (3 CARBOXYPROPYL) 6 (4 METHOXYPHENYL)PYRIDAZINIUM BROMIDE; 4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID A RECEPTOR BLOCKING AGENT; BICUCULLINE; FLUNITRAZEPAM; MENTHOL; MUSCIMOL; PICROTOXIN; THYMOL;

ALLOSTERISM; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN CELL; CELL CULTURE; CELL VIABILITY; CHLORIDE TRANSPORT; CONTROLLED STUDY; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; DRUG MECHANISM; DRUG RECEPTOR BINDING; DRUG STRUCTURE; FEMALE; FETUS; HYDROGEN BOND; MOUSE; NONHUMAN; PHARMACOPHORE; PRIORITY JOURNAL;

ANESTHETICS, INTRAVENOUS; ANIMALS; CELL SURVIVAL; CELLS, CULTURED; CEREBRAL CORTEX; CHLORIDE CHANNELS; COMPUTER SIMULATION; FEMALE; FLUNITRAZEPAM; GABA AGONISTS; GABA MODULATORS; GAMMA-AMINOBUTYRIC ACID; L-LACTATE DEHYDROGENASE; MICE; MODELS, MOLECULAR; MODELS, NEUROLOGICAL; MUSCIMOL; NEURONS; NEUROTOXINS; PREGNANCY; PROPIDIUM; PROPOFOL; RECEPTORS, GABA-A; THYMOL;

EID: 30344454228     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2005.07.009     Document Type: Article

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