Overcoming diabetes-induced hyperglycemia through inhibition of hepatic phosphoenolpyruvate carboxykinase (GTP) with RNAi

Molecular Therapy

Volumn 13, Issue 2, 2006, Pages 401-410

  Gómez Valadés, Alicia G ^a   Vidal Alabró, Anna ^a   Molas, Maria ^a   Boada, Jordi ^a   Bermúdez, Jordi ^a   Bartrons, Ramon ^a   Perales, José C ^a  

^a UNIVERSITY OF BARCELONA   (Spain)

Author keywords

Diabetes mellitus; Gluconeogenesis; Hydrodynamic gene transfer; Phosphoenolpyruvate carboxykinase; RNA interference

Indexed keywords

FATTY ACID; GLUCOSE; LIVER ENZYME; PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP); SHORT HAIRPIN RNA; STEROL REGULATORY ELEMENT BINDING PROTEIN 1C; TRIACYLGLYCEROL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; ENZYME ACTIVITY; ENZYME INACTIVATION; EXPRESSION VECTOR; FATTY LIVER; GENE SILENCING; GENE THERAPY; GLUCONEOGENESIS; GLUCOSE BLOOD LEVEL; GLUCOSE TOLERANCE; HUMAN; HUMAN CELL; HYPERGLYCEMIA; LACTIC ACIDOSIS; LIPID METABOLISM; MALE; MOUSE; NONHUMAN; PROTEIN CONTENT; RNA INTERFERENCE;

ANIMALS; CELL LINE, TUMOR; DIABETES MELLITUS, EXPERIMENTAL; EIF-2 KINASE; GENE SILENCING; GENE TARGETING; GENE TRANSFER TECHNIQUES; HUMANS; HYPERGLYCEMIA; INTERFERONS; LIVER; MALE; MICE; MICE, INBRED ICR; PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP); RNA INTERFERENCE;

ANIMALIA;

EID: 30344450829     PISSN: 15250016     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ymthe.2005.08.026     Document Type: Article

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