메뉴 건너뛰기




Volumn 137, Issue 3, 2006, Pages 971-980

Alteration of activator protein 1 DNA binding activity in gentamicin-induced hair cell degeneration

Author keywords

Aminoglycosides; Immediate early genes; Inner and outer hair cells; Organ of Corti; Signaling pathways

Indexed keywords

GENTAMICIN; PROTEIN C FOS; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR AP 1;

EID: 30144434026     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2005.10.010     Document Type: Article
Times cited : (10)

References (63)
  • 1
    • 0027303999 scopus 로고
    • Developmental regulation of Fos and Fos-related antigens in cerebral cortex, striatum, hippocampus, and cerebellum of the rat
    • A.A. Alcantara, W.T. Greenough Developmental regulation of Fos and Fos-related antigens in cerebral cortex, striatum, hippocampus, and cerebellum of the rat J Comp Neurol 334 1993 75 85
    • (1993) J Comp Neurol , vol.334 , pp. 75-85
    • Alcantara, A.A.1    Greenough, W.T.2
  • 2
    • 0025720735 scopus 로고
    • The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation
    • P. Angel, M. Karin The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation Biochim Biophys Acta 1072 1991 129 157
    • (1991) Biochim Biophys Acta , vol.1072 , pp. 129-157
    • Angel, P.1    Karin, M.2
  • 3
    • 0035971572 scopus 로고    scopus 로고
    • Function and regulation of AP-1 subunits in skin physiology and pathology
    • P. Angel, A. Szabowski, M. Schorpp-Kistner Function and regulation of AP-1 subunits in skin physiology and pathology Oncogene 20 2001 2413 2423
    • (2001) Oncogene , vol.20 , pp. 2413-2423
    • Angel, P.1    Szabowski, A.2    Schorpp-Kistner, M.3
  • 4
    • 0032979438 scopus 로고    scopus 로고
    • Amino-terminal phosphorylation of c-Jun regulates stress-induced apoptosis and cellular proliferation
    • A. Behrens, M. Sibilia, E.F. Wagner Amino-terminal phosphorylation of c-Jun regulates stress-induced apoptosis and cellular proliferation Nat Genet 21 1999 326 329
    • (1999) Nat Genet , vol.21 , pp. 326-329
    • Behrens, A.1    Sibilia, M.2    Wagner, E.F.3
  • 5
    • 0036935996 scopus 로고    scopus 로고
    • [Rescue of auditory hair cells from ototoxicity by CEP-11 004, an inhibitor of the JNK signaling pathway]
    • D. Bodmer, D. Brors, M. Bodmer, A.F. Ryan [Rescue of auditory hair cells from ototoxicity by CEP-11 004, an inhibitor of the JNK signaling pathway] Laryngorhinootologie 81 2002 853 856
    • (2002) Laryngorhinootologie , vol.81 , pp. 853-856
    • Bodmer, D.1    Brors, D.2    Bodmer, M.3    Ryan, A.F.4
  • 6
    • 0036805476 scopus 로고    scopus 로고
    • Rescue of auditory hair cells from aminoglycoside toxicity by Clostridium difficile toxin B, an inhibitor of the small GTPases Rho/Rac/Cdc42
    • D. Bodmer, D. Brors, K. Pak, B. Gloddek, A. Ryan Rescue of auditory hair cells from aminoglycoside toxicity by Clostridium difficile toxin B, an inhibitor of the small GTPases Rho/Rac/Cdc42 Hear Res 172 2002 81 86
    • (2002) Hear Res , vol.172 , pp. 81-86
    • Bodmer, D.1    Brors, D.2    Pak, K.3    Gloddek, B.4    Ryan, A.5
  • 7
    • 0036844412 scopus 로고    scopus 로고
    • Inhibition of the c-Jun N-terminal kinase signaling pathway influences neurite outgrowth of spiral ganglion neurons in vitro
    • D. Bodmer, B. Gloddek, A.F. Ryan, J. Huverstuhl, D. Brors Inhibition of the c-Jun N-terminal kinase signaling pathway influences neurite outgrowth of spiral ganglion neurons in vitro Laryngoscope 112 2002 2057 2061
    • (2002) Laryngoscope , vol.112 , pp. 2057-2061
    • Bodmer, D.1    Gloddek, B.2    Ryan, A.F.3    Huverstuhl, J.4    Brors, D.5
  • 10
    • 0030297554 scopus 로고    scopus 로고
    • Direct effects of intraperilymphatic reactive oxygen species generation on cochlear function
    • W.J. Clerici, L. Yang Direct effects of intraperilymphatic reactive oxygen species generation on cochlear function Hear Res 101 1996 14 22
    • (1996) Hear Res , vol.101 , pp. 14-22
    • Clerici, W.J.1    Yang, L.2
  • 11
    • 0032949289 scopus 로고    scopus 로고
    • Attenuation of aminoglycoside-induced cochlear damage with the metabolic antioxidant alpha-lipoic acid
    • B.J. Conlon, J.M. Aran, J.P. Erre, D.W. Smith Attenuation of aminoglycoside-induced cochlear damage with the metabolic antioxidant alpha-lipoic acid Hear Res 128 1999 40 44
    • (1999) Hear Res , vol.128 , pp. 40-44
    • Conlon, B.J.1    Aran, J.M.2    Erre, J.P.3    Smith, D.W.4
  • 12
    • 0031883495 scopus 로고    scopus 로고
    • Attenuation of neomycin ototoxicity by iron chelation
    • B.J. Conlon, B.P. Perry, D.W. Smith Attenuation of neomycin ototoxicity by iron chelation Laryngoscope 108 1998 284 287
    • (1998) Laryngoscope , vol.108 , pp. 284-287
    • Conlon, B.J.1    Perry, B.P.2    Smith, D.W.3
  • 13
    • 0031882402 scopus 로고    scopus 로고
    • Supplemental iron exacerbates aminoglycoside ototoxicity in vivo
    • B.J. Conlon, D.W. Smith Supplemental iron exacerbates aminoglycoside ototoxicity in vivo Hear Res 115 1998 1 5
    • (1998) Hear Res , vol.115 , pp. 1-5
    • Conlon, B.J.1    Smith, D.W.2
  • 14
    • 0028329953 scopus 로고
    • JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain
    • B. Derijard, M. Hibi, I.H. Wu, T. Barrett, B. Su, T. Deng, M. Karin, R.J. Davis JNK1 a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain Cell 76 1994 1025 1037
    • (1994) Cell , vol.76 , pp. 1025-1037
    • Derijard, B.1    Hibi, M.2    Wu, I.H.3    Barrett, T.4    Su, B.5    Deng, T.6    Karin, M.7    Davis, R.J.8
  • 15
    • 0032763678 scopus 로고    scopus 로고
    • Selective loss of inner hair cells and type-I ganglion neurons in carboplatin-treated chinchillas. Mechanisms of damage and protection
    • D.L. Ding, J. Wang, R. Salvi, D. Henderson, B.H. Hu, S.L. McFadden, M. Mueller Selective loss of inner hair cells and type-I ganglion neurons in carboplatin-treated chinchillas. Mechanisms of damage and protection Ann N Y Acad Sci 884 1999 152 170
    • (1999) Ann N Y Acad Sci , vol.884 , pp. 152-170
    • Ding, D.L.1    Wang, J.2    Salvi, R.3    Henderson, D.4    Hu, B.H.5    McFadden, S.L.6    Mueller, M.7
  • 16
    • 0022405232 scopus 로고
    • Outer hair cell loss and supporting cell expansion following chronic gentamicin treatment
    • A. Forge Outer hair cell loss and supporting cell expansion following chronic gentamicin treatment Hear Res 19 1985 171 182
    • (1985) Hear Res , vol.19 , pp. 171-182
    • Forge, A.1
  • 19
    • 0030049439 scopus 로고    scopus 로고
    • Activation of mitogen-activated protein kinase by H2O2. Role in cell survival following oxidant injury
    • K.Z. Guyton, Y. Liu, M. Gorospe, Q. Xu, N.J. Holbrook Activation of mitogen-activated protein kinase by H2O2. Role in cell survival following oxidant injury J Biol Chem 271 1996 4138 4142
    • (1996) J Biol Chem , vol.271 , pp. 4138-4142
    • Guyton, K.Z.1    Liu, Y.2    Gorospe, M.3    Xu, Q.4    Holbrook, N.J.5
  • 20
    • 0026769565 scopus 로고
    • A rapid method for the isolation of DNA-binding proteins from purified nuclei of tissues and cells in culture
    • O. Hagenbuchle, P.K. Wellauer A rapid method for the isolation of DNA-binding proteins from purified nuclei of tissues and cells in culture Nucleic Acids Res 20 1992 3555 3559
    • (1992) Nucleic Acids Res , vol.20 , pp. 3555-3559
    • Hagenbuchle, O.1    Wellauer, P.K.2
  • 21
    • 0000096735 scopus 로고
    • Drug ototoxicity
    • W.D. Keidel W.D. Neff Springer Verlag Berlin
    • J.E. Hawkins Jr Drug ototoxicity W.D. Keidel W.D. Neff Handbook of sensory physiology Vol. 5 1976 Springer Verlag Berlin 707 748
    • (1976) Handbook of Sensory Physiology , vol.5 , pp. 707-748
    • Hawkins, J.E.1    Jr2
  • 22
    • 0001649159 scopus 로고
    • Streptomycin in treatment of clinical tuberculosis: A preliminary report
    • H.C. Hinshaw, W.H. Feldman Streptomycin in treatment of clinical tuberculosis a preliminary report Proc Mayo Clinic 20 1945 313 318
    • (1945) Proc Mayo Clinic , vol.20 , pp. 313-318
    • Hinshaw, H.C.1    Feldman, W.H.2
  • 23
    • 0031081406 scopus 로고    scopus 로고
    • Reactive oxygen species in chick hair cells after gentamicin exposure in vitro
    • K. Hirose, D.M. Hockenbery, E.W. Rubel Reactive oxygen species in chick hair cells after gentamicin exposure in vitro Hear Res 104 1997 1 14
    • (1997) Hear Res , vol.104 , pp. 1-14
    • Hirose, K.1    Hockenbery, D.M.2    Rubel, E.W.3
  • 24
    • 0023575936 scopus 로고
    • Nutritional status, glutathione levels, and ototoxicity of loop diuretics and aminoglycoside antibiotics
    • D.W. Hoffman, C.A. Whitworth, K.L. Jones, L.P. Rybak Nutritional status, glutathione levels, and ototoxicity of loop diuretics and aminoglycoside antibiotics Hear Res 31 1987 217 222
    • (1987) Hear Res , vol.31 , pp. 217-222
    • Hoffman, D.W.1    Whitworth, C.A.2    Jones, K.L.3    Rybak, L.P.4
  • 27
    • 0028322193 scopus 로고
    • Signal transduction from the cell surface to the nucleus through the phosphorylation of transcription factors
    • M. Karin Signal transduction from the cell surface to the nucleus through the phosphorylation of transcription factors Curr Opin Cell Biol 6 1994 415 424
    • (1994) Curr Opin Cell Biol , vol.6 , pp. 415-424
    • Karin, M.1
  • 28
    • 0029025008 scopus 로고
    • Kainic acid-induced neuronal death is associated with DNA damage and a unique immediate-early gene response in c-fos-lacZ transgenic rats
    • G.M. Kasof, A. Mandelzys, S.D. Maika, R.E. Hammer, T. Curran, J.I. Morgan Kainic acid-induced neuronal death is associated with DNA damage and a unique immediate-early gene response in c-fos-lacZ transgenic rats J Neurosci 15 1995 4238 4249
    • (1995) J Neurosci , vol.15 , pp. 4238-4249
    • Kasof, G.M.1    Mandelzys, A.2    Maika, S.D.3    Hammer, R.E.4    Curran, T.5    Morgan, J.I.6
  • 29
    • 0037689449 scopus 로고    scopus 로고
    • Hearing and hair cells are protected by adenoviral gene therapy with TGF-beta1 and GDNF
    • K. Kawamoto, M. Yagi, T. Stover, S. Kanzaki, Y. Raphael Hearing and hair cells are protected by adenoviral gene therapy with TGF-beta1 and GDNF Mol Ther 7 2003 484 492
    • (2003) Mol Ther , vol.7 , pp. 484-492
    • Kawamoto, K.1    Yagi, M.2    Stover, T.3    Kanzaki, S.4    Raphael, Y.5
  • 30
    • 0033522169 scopus 로고    scopus 로고
    • Attenuated expression of the serum responsive T1 gene in ras transformed fibroblasts due to the inhibition of c-fos gene activity
    • R. Kessler, A. Zacharova-Albinger, N.B. Laursen, M. Kalousek, R. Klemenz Attenuated expression of the serum responsive T1 gene in ras transformed fibroblasts due to the inhibition of c-fos gene activity Oncogene 18 1999 1733 1744
    • (1999) Oncogene , vol.18 , pp. 1733-1744
    • Kessler, R.1    Zacharova-Albinger, A.2    Laursen, N.B.3    Kalousek, M.4    Klemenz, R.5
  • 32
    • 0031039206 scopus 로고    scopus 로고
    • Variations in Jun and Fos protein expression and AP-1 activity in cycling, resting and stimulated fibroblasts
    • D. Lallemand, G. Spyrou, M. Yaniv, C.M. Pfarr Variations in Jun and Fos protein expression and AP-1 activity in cycling, resting and stimulated fibroblasts Oncogene 14 1997 819 830
    • (1997) Oncogene , vol.14 , pp. 819-830
    • Lallemand, D.1    Spyrou, G.2    Yaniv, M.3    Pfarr, C.M.4
  • 33
    • 2942734964 scopus 로고    scopus 로고
    • [Aminoglycoside- and cisplatin-ototoxicity: From basic science to clinics]
    • J. Lautermann, N. Dehne, J. Schacht, K. Jahnke [Aminoglycoside- and cisplatin-ototoxicity from basic science to clinics] Laryngorhinootologie 83 2004 317 323
    • (2004) Laryngorhinootologie , vol.83 , pp. 317-323
    • Lautermann, J.1    Dehne, N.2    Schacht, J.3    Jahnke, K.4
  • 34
    • 0032937879 scopus 로고    scopus 로고
    • Withdrawal of survival factors results in activation of the JNK pathway in neuronal cells leading to Fas ligand induction and cell death
    • H. Le-Niculescu, E. Bonfoco, Y. Kasuya, F.X. Claret, D.R. Green, M. Karin Withdrawal of survival factors results in activation of the JNK pathway in neuronal cells leading to Fas ligand induction and cell death Mol Cell Biol 19 1999 751 763
    • (1999) Mol Cell Biol , vol.19 , pp. 751-763
    • Le-Niculescu, H.1    Bonfoco, E.2    Kasuya, Y.3    Claret, F.X.4    Green, D.R.5    Karin, M.6
  • 36
    • 0029005753 scopus 로고
    • Two modes of hair cell loss from the vestibular sensory epithelia of the guinea pig inner ear
    • L. Li, G. Nevill, A. Forge Two modes of hair cell loss from the vestibular sensory epithelia of the guinea pig inner ear J Comp Neurol 355 1995 405 417
    • (1995) J Comp Neurol , vol.355 , pp. 405-417
    • Li, L.1    Nevill, G.2    Forge, A.3
  • 38
    • 1642523179 scopus 로고    scopus 로고
    • Modulation of activator protein 1/DNA binding activity by acoustic overstimulation in the guinea-pig cochlea
    • T. Matsunobu, K. Ogita, J. Schacht Modulation of activator protein 1/DNA binding activity by acoustic overstimulation in the guinea-pig cochlea Neuroscience 123 2004 1037 1043
    • (2004) Neuroscience , vol.123 , pp. 1037-1043
    • Matsunobu, T.1    Ogita, K.2    Schacht, J.3
  • 39
    • 0031039113 scopus 로고    scopus 로고
    • Transformation by ras modifies AP1 composition and activity
    • F. Mechta, D. Lallemand, C.M. Pfarr, M. Yaniv Transformation by ras modifies AP1 composition and activity Oncogene 14 1997 837 847
    • (1997) Oncogene , vol.14 , pp. 837-847
    • Mechta, F.1    Lallemand, D.2    Pfarr, C.M.3    Yaniv, M.4
  • 41
    • 0027494118 scopus 로고
    • Hearing loss
    • J.B. Nadol Jr Hearing loss N Engl J Med 329 1993 1092 1102
    • (1993) N Engl J Med , vol.329 , pp. 1092-1102
    • Nadol, J.B.1    Jr2
  • 42
    • 0034689579 scopus 로고    scopus 로고
    • Acoustic trauma enhances DNA binding of transcription factor AP-1 in the guinea pig inner ear
    • K. Ogita, T. Matsunobu, J. Schacht Acoustic trauma enhances DNA binding of transcription factor AP-1 in the guinea pig inner ear Neuroreport 11 2000 859 862
    • (2000) Neuroreport , vol.11 , pp. 859-862
    • Ogita, K.1    Matsunobu, T.2    Schacht, J.3
  • 43
  • 44
    • 0034691118 scopus 로고    scopus 로고
    • Protection of auditory receptors and neurons: Evidence for interactive damage
    • A.F. Ryan Protection of auditory receptors and neurons evidence for interactive damage Proc Natl Acad Sci USA 97 2000 6939 6940
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 6939-6940
    • Ryan, A.F.1
  • 46
    • 0024380087 scopus 로고
    • Rapid detection of octamer binding proteins with 'mini-extracts,' prepared from a small number of cells
    • E. Schreiber, P. Matthias, M.M. Muller, W. Schaffner Rapid detection of octamer binding proteins with 'mini-extracts,' prepared from a small number of cells Nucleic Acids Res 17 1989 6419
    • (1989) Nucleic Acids Res , vol.17 , pp. 6419
    • Schreiber, E.1    Matthias, P.2    Muller, M.M.3    Schaffner, W.4
  • 47
    • 0032961615 scopus 로고    scopus 로고
    • Stimulation of free radical formation by aminoglycoside antibiotics
    • S.H. Sha, J. Schacht Stimulation of free radical formation by aminoglycoside antibiotics Hear Res 128 1999 112 118
    • (1999) Hear Res , vol.128 , pp. 112-118
    • Sha, S.H.1    Schacht, J.2
  • 48
    • 0035971493 scopus 로고    scopus 로고
    • AP-1 in cell proliferation and survival
    • E. Shaulian, M. Karin AP-1 in cell proliferation and survival Oncogene 20 2001 2390 2400
    • (2001) Oncogene , vol.20 , pp. 2390-2400
    • Shaulian, E.1    Karin, M.2
  • 49
    • 0036098552 scopus 로고    scopus 로고
    • AP-1 as a regulator of cell life and death
    • E. Shaulian, M. Karin AP-1 as a regulator of cell life and death Nat Cell Biol 4 2002 E131 E136
    • (2002) Nat Cell Biol , vol.4
    • Shaulian, E.1    Karin, M.2
  • 50
    • 0036498997 scopus 로고    scopus 로고
    • Expression of c-Fos after noise-induced temporary threshold shift in the guinea pig cochlea
    • K. Shizuki, K. Ogawa, T. Matsunobu, J. Kanzaki, K. Ogita Expression of c-Fos after noise-induced temporary threshold shift in the guinea pig cochlea Neurosci Lett 320 2002 73 76
    • (2002) Neurosci Lett , vol.320 , pp. 73-76
    • Shizuki, K.1    Ogawa, K.2    Matsunobu, T.3    Kanzaki, J.4    Ogita, K.5
  • 51
    • 0032804643 scopus 로고    scopus 로고
    • The cochleovestibular system/ototoxicity/clinical issues
    • A. Shulman The cochleovestibular system/ototoxicity/clinical issues Ann N Y Acad Sci 884 1999 433 436
    • (1999) Ann N Y Acad Sci , vol.884 , pp. 433-436
    • Shulman, A.1
  • 52
    • 0016758011 scopus 로고
    • Organotypic development of the organ of Corti in culture
    • H.M. Sobkowicz, B. Bereman, J.E. Rose Organotypic development of the organ of Corti in culture J Neurocytol 4 1975 543 572
    • (1975) J Neurocytol , vol.4 , pp. 543-572
    • Sobkowicz, H.M.1    Bereman, B.2    Rose, J.E.3
  • 54
    • 0030778977 scopus 로고    scopus 로고
    • Protection from gentamicin ototoxicity by iron chelators in guinea pig in vivo
    • B.B. Song, D.J. Anderson, J. Schacht Protection from gentamicin ototoxicity by iron chelators in guinea pig in vivo J Pharmacol Exp Ther 282 1997 369 377
    • (1997) J Pharmacol Exp Ther , vol.282 , pp. 369-377
    • Song, B.B.1    Anderson, D.J.2    Schacht, J.3
  • 55
    • 0032527629 scopus 로고    scopus 로고
    • Iron chelators protect from aminoglycoside-induced cochleo- and vestibulo-toxicity
    • B.B. Song, S.H. Sha, J. Schacht Iron chelators protect from aminoglycoside-induced cochleo- and vestibulo-toxicity Free Radic Biol Med 25 1998 189 195
    • (1998) Free Radic Biol Med , vol.25 , pp. 189-195
    • Song, B.B.1    Sha, S.H.2    Schacht, J.3
  • 56
    • 0031013486 scopus 로고    scopus 로고
    • Aminoglycoside nephrotoxicity
    • S.K. Swan Aminoglycoside nephrotoxicity Semin Nephrol 17 1997 27 33
    • (1997) Semin Nephrol , vol.17 , pp. 27-33
    • Swan, S.K.1
  • 58
    • 0015041379 scopus 로고
    • Organ culture of the mammalian inner ear
    • T.R. Van de Water, R.J. Ruben Organ culture of the mammalian inner ear Acta Otolaryngol 71 1971 303 312
    • (1971) Acta Otolaryngol , vol.71 , pp. 303-312
    • Van De Water, T.R.1    Ruben, R.J.2
  • 59
    • 0141457877 scopus 로고    scopus 로고
    • A peptide inhibitor of c-Jun N-terminal kinase protects against both aminoglycoside and acoustic trauma-induced auditory hair cell death and hearing loss
    • J. Wang, T.R. Van De Water, C. Bonny, F. de Ribaupierre, J.L. Puel, A. Zine A peptide inhibitor of c-Jun N-terminal kinase protects against both aminoglycoside and acoustic trauma-induced auditory hair cell death and hearing loss J Neurosci 23 2003 8596 8607
    • (2003) J Neurosci , vol.23 , pp. 8596-8607
    • Wang, J.1    Van De Water, T.R.2    Bonny, C.3    De Ribaupierre, F.4    Puel, J.L.5    Zine, A.6
  • 60
    • 0028880006 scopus 로고
    • Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis
    • Z. Xia, M. Dickens, J. Raingeaud, R.J. Davis, M.E. Greenberg Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis Science 270 1995 1326 1331
    • (1995) Science , vol.270 , pp. 1326-1331
    • Xia, Z.1    Dickens, M.2    Raingeaud, J.3    Davis, R.J.4    Greenberg, M.E.5
  • 61
    • 4043091276 scopus 로고    scopus 로고
    • Delayed production of free radicals following noise exposure
    • D. Yamashita, H.Y. Jiang, J. Schacht, J.M. Miller Delayed production of free radicals following noise exposure Brain Res 1019 2004 201 209
    • (2004) Brain Res , vol.1019 , pp. 201-209
    • Yamashita, D.1    Jiang, H.Y.2    Schacht, J.3    Miller, J.M.4
  • 62
    • 0035985743 scopus 로고    scopus 로고
    • Blockade of c-Jun N-terminal kinase pathway attenuates gentamicin-induced cochlear and vestibular hair cell death
    • J. Ylikoski, L. Xing-Qun, J. Virkkala, U. Pirvola Blockade of c-Jun N-terminal kinase pathway attenuates gentamicin-induced cochlear and vestibular hair cell death Hear Res 166 2002 33 43
    • (2002) Hear Res , vol.166 , pp. 33-43
    • Ylikoski, J.1    Xing-Qun, L.2    Virkkala, J.3    Pirvola, U.4
  • 63
    • 4544300185 scopus 로고    scopus 로고
    • The MAPK/JNK signalling pathway offers potential therapeutic targets for the prevention of acquired deafness
    • A. Zine, T.R. van de Water The MAPK/JNK signalling pathway offers potential therapeutic targets for the prevention of acquired deafness Curr Drug Targets CNS Neurol Disord 3 2004 325 332
    • (2004) Curr Drug Targets CNS Neurol Disord , vol.3 , pp. 325-332
    • Zine, A.1    Van De Water, T.R.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.