Different mechanisms mediate development and expression of tolerance and dependence for peripheral μ-opioid antinociception in rat

Journal of Neuroscience

Volumn 17, Issue 20, 1997, Pages 8018-8023

  Aley, Kochuvelikakam O ^a   Levine, Jon D ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Adenylyl cyclase; Calcium; Nitric oxide; Nociception; Opioids; Prostaglandin E2; Protein kinase A; Protein kinase C

Indexed keywords

2',5' DIDEOXYADENOSINE; 3,4,5 TRIMETHOXYBENZOIC ACID 8 (DIETHYLAMINO)OCTYL ESTER; ADENYLATE CYCLASE; CHELERYTHRINE; CYCLIC AMP DEPENDENT PROTEIN KINASE; ENKEPHALIN[2 DEXTRO ALANINE 4 METHYLPHENYLALANINE 5 GLYCINE]; MU OPIATE RECEPTOR; N(G) METHYLARGININE; NITRIC OXIDE; PROSTAGLANDIN E2; PROTEIN KINASE C; QUIN 2;

ANIMAL EXPERIMENT; ANTINOCICEPTION; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG MECHANISM; DRUG TOLERANCE; HYPERALGESIA; INTRADERMAL DRUG ADMINISTRATION; MALE; NONHUMAN; OPIATE ADDICTION; PRIORITY JOURNAL; RAT; SECOND MESSENGER;

EID: 0030771918     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.17-20-08018.1997     Document Type: Article

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