Antisense oligodeoxynucleotides to opioid mu and delta receptors reduced morphine dependence in mice: Role of delta-2 opioid receptors

Journal of Pharmacology and Experimental Therapeutics

Volumn 280, Issue 3, 1997, Pages 1423-1431

  Sánchez Blázquez, Pilar ^a,b   García España, Antonio ^a   Garzón, Javier ^a  

^a CSIC   (Spain)

^b INSTITUTO CAJAL   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ANTISENSE OLIGODEOXYNUCLEOTIDE; DELTA OPIATE RECEPTOR; DELTORPHIN; ENKEPHALIN[2 DEXTRO ALANINE 4 METHYLPHENYLALANINE 5 GLYCINE]; ENKEPHALIN[2 DEXTRO PENICILLAMINE 5 PENICILLAMINE]; IMMUNOGLOBULIN G; IODINE 125; MESSENGER RNA; MORPHINE; MU OPIATE RECEPTOR; NALOXONE;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTINOCICEPTION; ARTICLE; CONTROLLED STUDY; CORPUS STRIATUM; DIARRHEA; DRUG TOLERANCE; ISOTOPE LABELING; MALE; MORPHINE ADDICTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT; WEIGHT REDUCTION; WITHDRAWAL SYNDROME;

AMINO ACID SEQUENCE; ANIMALS; AUTORADIOGRAPHY; BLOTTING, WESTERN; CORPUS STRIATUM; INJECTIONS, INTRAVENTRICULAR; MALE; MICE; MOLECULAR SEQUENCE DATA; MORPHINE DEPENDENCE; NALOXONE; OLIGONUCLEOTIDES, ANTISENSE; RECEPTORS, OPIOID, DELTA; RECEPTORS, OPIOID, MU; SUBSTANCE WITHDRAWAL SYNDROME;

EID: 0030947808     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (53)

1. ABDELHAMID, E. E., SULTANA, M., PORTHOGHESE, P. S. AND TAKEMORI, A. E.: Selective blockage of delta opioid receptor prevents the development of morphine tolerance and dependence in mice. J. Pharmacol. Exp. Ther. 258: 299-303, 1991.
2. ABOOD, M. E., NOEL, M. A., FARNSWORTH, J. S. AND TAO, Q.: Molecular cloning and expression of a δ-opioid receptor from rat brain. J. Neurosci. Res. 37: 714-719, 1994.
3. ACETO, M. D., DEWEY, W. L., PORTHOGHESE, P. S. AND TAKEMORI, A. E.: Effect of β-funaltrexamine (β-FNA) on morphine dependence in rats and monkeys. Eur. J. Pharmacol. 123: 387-393, 1986.
4. 4]deltorphin antinociception by supraspinal, but not spinal, administration of an antisense oligodeoxynucleotide to an opioid delta receptor. Life Sci. Pharmacol. Lett. 55: PL37-PL43, 1994.
5. BILSKY, E. J., BERNSTEIN, R. N., HRUBY, V. J., ROTHMAN, R. B., LAI, J. AND PORRECA, F.: Characterization of antinociception to opioid receptor selective agonists after antisense oligodeoxynucleotide-mediated "knock-down" of opioid receptors in vivo. J. Pharmacol. Exp. Ther. 277: 491-501, 1996.
6. CACERES, A. AND KOSIK, K. S.: Inhibition of neurite polarity by tau antisense oligodeoxynucleotides in primary cerebellar neurons. Nature 343: 461-463, 1990.
7. CHEN, Y., MESTEK, A., LIU, J., HURLEY, J. A. AND Y. U., L.: Molecular cloning and functional expression of a mu-opioid receptor from rat brain. Mol. Pharmacol. 44: 8-12, 1993.
8. CHEN, X.-H., ADAMS, J. U., GELLER, E. B., DERIEL, J. K., ADLER, M. W. AND LIU-CHEN, L.-Y.: An antisense oligodeoxynucleotide to mu-opioid receptors inhibits mu-opioid receptor agonist-induced analgesia in rats. Eur. J. Pharmacol. 275: 105-108, 1995.
9. CHIASSON, B. J., ARMSTRONG, J. N., HOOPER, M. L., MURPHY, P. R. AND ROBERTSON, H. A.: The application of antisense oligonucleotide technology to the brain: some pitfalls. Cell. Mol. Neurobiol. 14: 507-521, 1994.
10. CHIEN, C. C., BROWN, G., PAN, Y. X. AND PASTERNAK, G. W.: Blockade of U50,488H analgesia by antisense oligodeoxynucleotides to a kappa opioid receptor. Eur. J. Pharmacol. 253: R7-R8, 1994.
11. DELANDER, G. E., PORTHOGHESE, P. S., AND TAKEMORI, A. E.: Role of spinal mu opioid receptors in the development of morphine tolerance and dependence. J. Pharmacol. Exp. Ther. 231: 91-96, 1984.
12. EVANS, C. J., KEITH, D. E., MORRISON, H., MAGENDZO, K. AND EDWARDS, R. H.: Cloning of a delta opioid receptor by functional expression. Science 258: 1952-1955, 1992.
13. GARZÓN, J. AND SÁNCHEZ-BLÁZQUEZ, P.: N-acetyl human β-endorphin (1-31) alleviates the morphine withdrawal syndrome in rodents: A comparative study with clonidine. Life Sci. 50: 2099-2109, 1992.
14. GARZÓN, J. AND SÁNCHEZ-BLÁZQUEZ, P.: In vivo injection of antibodies directed against the cloned mu opioid receptor blocked supraspinal analgesia induced by mu-agonists in mice. Life Sci. Pharmacol. Lett. 56: PL237-PL242, 1995.
15. GARZÓN, J., CASTRO, M. A., JUARROS, J. L. AND SÁNCHEZ-BLÁZQUEZ, P.: Antibodies raised against the N-terminal sequence of the delta opioid receptor blocked delta-mediated supraspinal antinociception in mice. Life Sci. Pharmacol. Lett. 54: PL191-PL196, 1994.
16. GARZÓN, J., JUARROS, J. L., CASTRO, M. A. AND SÁNCHEZ-BLÁZQUEZ, P.: Antibodies to the cloned mu-opioid receptor detect various molecular weight forms in areas of mouse brain. Mol. Pharmacol. 47: 738-744, 1995.
17. GILLARDON, F., BECK, H., UHLMANN, E., HERDEGEN, T., SANDKÜHLER, J., PEYMAN, A. AND ZIMMERMANN, M.: Inhibition of c-fos protein expression in rat spinal cord by antisense oligodeoxynucleotide superfusion. Eur. J. Neurosci. 6: 880-884, 1994.
18. 131I-labelled human growth hormone of high specific radioactivity. Biochem. J. 89: 114-123, 1963.
19. HÖLLT, V., SÁNCHEZ-BLÁZQUEZ, P. AND GARZÓN, J.: Multiple opioid ligands and receptors in the control of nociception. Philos. Trans. R. Soc. Lond. B Biol. Sci. 308: 299-310, 1985.
20. B receptors in rat cerebellar granule cells. J. Pharmacol. Exp. Ther. 264: 423-430, 1993.
21. KIEFFER. B. L., BEFORT, K., GAVERIAUX-RUFF, C. AND HIRTH, C. G.: The δ-opioid receptor: isolation of a cDNA by expression cloning and pharmacological characterization. Proc. Natl. Acad. Sci. U.S.A. 89: 12048-12052, 1992.
22. 2-agonist antinociception. NeuroReport 5: 1049-1052, 1994.
23. LING, G. S. F., MACLEOD, J. M., LEE, S., LOCKHART, S. H. AND PASTERNAK, G. W.: Separation of morphine analgesia from physical dependence. Science 226: 462-464, 1984.
24. 3H]Funaltrexamine-labeled μ-opioid receptors: Species variations in molecular mass and glycosylation by complex-type, N-linked oligosaccharides. Mol. Pharmacol. 44: 749-756, 1993.
25. LORD, J. A. H., WATERRFIELD, A. A., HUGHES, J. AND KOSTERLITZ, H. W.: Endogenous opioid peptides: Multiple agonists and receptors. Nature 267: 495-499, 1977.
26. MANSOUR, A., FOX, C. A., AKIL, H. AND WATSON, S. J.: Opioid-receptor mRNA expression in the rat CNS: anatomical and functional implications. Trends Neurosci. 18: 22-29, 1995.
27. MARTIN, W. R., EADES, C. G., THOMPSON, J. A., HUPPLER, R. E., AND GILBERT, P. E.: The effects of morphine and nalorphine-like drugs in the nondependent and morphine dependent chronic spinal dog. J. Pharmacol. Exp. Ther. 197: 517-532, 1976.
28. MATTEUCCI, M. D. AND CARUTHERS, M. H.: Synthesis of deoxyoligo nucleotides on a polymer support. J. Am. Chem. Soc. 103: 3185-3191, 1981.
29. 2]deltorphin II in mice; evidence for delta opioid receptor subtypes. J. Pharmacol. Exp. Ther. 258: 583-587, 1991.
30. MIN, B. H., AUGUSTIN, L. B., FELSHEIM, R. F., FUCHS, J. A. AND LOH, H. H.: Genomic structure and analysis of promoter sequence of a mouse mu opioid receptor gene. Proc. Natl. Acad. Sci. U.S.A. 91: 9081-9085, 1994.
31. 2 opioid receptors in the development of morphine dependence in mice. J. Pharmacol. Exp. Ther. 264: 1141-1145, 1993.
32. PASTERNAK, G. W. AND SNYDER, S. H.: Identification of novel high affinity opiate receptor binding in rat brain. Nature 253: 563-565, 1975.
33. 5]enkephalin in the mouse. J. Pharmacol. Exp. Ther. 241: 393-399, 1987.
34. ROSSI, G., PAN Y.-X., CHENG, J. AND PASTERNAK, G. W.: Blockade of morphine analgesia by an antisense oligodeoxynucleotide against the mu receptor. Life Sci. Pharmacol. Sci. 54: PL375-PL379, 1994.
35. SÁNCHEZ-BLÁZQUEZ, P. AND GARZÓN, J.: Evaluation of delta receptor mediation of supraspinal opioid analgesia by in vivo protection against the β-funaltrexamine antagonist effect. Eur. J. Pharmacol. 159: 9-23, 1989.
36. s transducer proteins reduced the morphine withdrawal syndrome in mice. Life Sci. Pharmacol. Lett. 55: PL445-PL450, 1994.
37. SÁNCHEZ-BLÁZQUEZ, P., GARCÍA-ESPAÑA, A. AND GARZÓN, J.: In vivo injection of oligodeoxynucleotides to Gα subunits and supraspinal analgesia evoked by mu and delta opioid agonists. J. Pharmacol. Exp. Ther. 275: 1590-1596, 1995.
38. SÁNCHEZ-BLÁZQUEZ, P., RODRIGUEZ, M. D. AND GARZÓN, J.: Antibodies directed against the mu-opioid receptor alleviated multiple signs of morphine withdrawal in mice. Life Sci. Pharmacol. Lett. 59: PL87-PL92 1996.
39. SOFUOGLU, M., PORTHOGHESE, P. S. AND TAKEMORI, A. E.: Differential antagonism of delta opioid agonists by naltrindole and its benzofuran analog (NTB) in mice: Evidence for delta opioid receptor subtypes. J. Pharmacol. Exp. Ther. 257: 676-680, 1991.
40. STANDIFER, K. M., CHIEN, CH.-CH, WAHLESTEDT, C., BROWN, G. P. AND PASTERNAK, G. W.: Selective loss of delta opioid analgesia and binding by antisense oligodeoxynucleotides to a delta opioid receptor. Neuron 12: 805-810, 1994.
41. THOMPSON, R. C., MANSOUR, A., AKIL, H. AND WATSON, S. J.: Cloning and pharmacological characterization of a rat μ opioid receptor. Neuron 11: 903-913, 1993.
42. TSENG, L. F., COLLINS, K. A. AND KAMPINE, J. P.: Antisense oligodeoxynucleotide to a delta-opioid receptor selectively blocks the spinal antinociception induced by delta-, but not mu-or kappa-opioid receptor agonists in the mouse. Eur. J. Pharmacol. 258: R1-R3, 1994.
43. UHL, G. R., CHILDERS, S. AND PASTERNAK, G. W.: An opiate-receptor gene family reunion. Trends Neurosci. 17: 89-92, 1994.
44. VU, A. AND HIRSCHBEIN, B. L.: Internucleotide phosphite sulfurization with tetraethylthiuram disulfide phosphorothioate oligonucleotide synthesis via phosphoramidite chemistry. Tetrahedron Lett. 32: 3005-3008, 1991.
45. WAGNER, R. W.: Gene inhibition using antisense oligodeoxynucleotides. Nature 372: 333-335, 1994.
46. WAHLESTEDT, C., PICH, E. M., KOOB, G. F., YEE, F. AND HELLING, M.: Modulation of anxiety and neuropeptide Y-Y1 receptors by antisense oligodeoxynucleotides. Science 259: 528-531, 1993.
47. WANG, J. B., IMAI, Y., EPPLER, C. M., GREGOR, P., SPIVAK, C. E. AND UHL, G. R.: Mu-opiate receptor: cDNA cloning and expression. Proc. Natl. Acad. Sci. U.S.A. 90: 10230-10234, 1993.
48. WAY, E. L., LOH, H. H. AND SHEN, F.-H.: Simultaneous quantitative assessment of morphine tolerance and physical dependence. J. Pharmacol. Exp. Ther. 167: 1-8, 1969.
49. WOLOZIN, B. L. AND PASTERNAK, G. W.: Classification of multiple morphine and enkephalin binding sites in the central nervous system. Proc. Natl. Acad. Sci. U.S.A. 78: 6181-6185, 1981.
50. YANG, C. C. H., CHANG, J. Y. H. AND CHAN, S. H. H.: Unsustained dipsogenic response to chronic central infusion of angiotensin-III in spontaneously hypertensive rats. Endocrinology 132: 405-409, 1993.
51. 2 receptors: Behavioral correlates. Neurosci. Lett. 161: 223-226, 1993.
52. 2 dopamine receptors in mouse striatum. J. Pharmacol. Exp. Ther. 268: 1015-1023, 1994.
53. ZIMPRICH, A., SIMON, T. AND HÖLLT, V.: Cloning and expression of an isoform of the rat mu opioid receptor (rMOR1B) which differs in agonist induced desensitization from rMOR1. FEBS Lett. 359: 142-146, 1995.