Synthesis, opioid receptor binding, and biological activities of naltrexone-derived pyrido- and pyrimidomorphinans

Journal of Medicinal Chemistry

Volumn 42, Issue 18, 1999, Pages 3527-3538

  Ananthan, Subramaniam ^a   Kezar III, Hollis S ^a   Carter, Ronald L ^a   Saini, Surendra K ^a   Rice, Kenner C ^c   Wells, Jennifer L ^d   Davis, Peg ^e   Xu, Heng ^b   Dersch, Christina M ^b   Bilsky, Edward J ^d   Porreca, Frank ^e   Rothman, Richard B ^b  

^a SOUTHERN RESEARCH INSTITUTE   (United States)

^b NATIONAL INSTITUTE ON DRUG ABUSE   (United States)

^c NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^d UNIVERSITY OF NORTHERN COLORADO   (United States)

^e UNIVERSITY OF ARIZONA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MORPHINAN DERIVATIVE; NALTREXONE; OPIATE RECEPTOR; PYRIMIDINONE DERIVATIVE;

ANTINOCICEPTION; ARTICLE; BINDING AFFINITY; BINDING SITE; DERIVATIZATION; DRUG POTENCY; DRUG SYNTHESIS; LIGAND BINDING; MOLECULAR CLONING; PROTON NUCLEAR MAGNETIC RESONANCE; RECEPTOR BINDING; TAIL FLICK TEST;

ANALGESICS; ANIMALS; BINDING, COMPETITIVE; BRAIN; ENKEPHALIN, ALA(2)-MEPHE(4)-GLY(5)-; ENKEPHALIN, LEUCINE-2-ALANINE; ENKEPHALINS; GUINEA PIGS; ILEUM; MALE; MICE; MICE, INBRED STRAINS; MORPHINANS; MORPHINE; MUSCLE CONTRACTION; NALTREXONE; PROTEIN BINDING; RATS; RECEPTORS, OPIOID; VAS DEFERENS;

EID: 0033539108     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm990039i     Document Type: Article

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