A mistletoe lectin (ML-1)-containing diet reduces the viability of a murine non-Hodgkin lymphoma tumor

Cancer Detection and Prevention

Volumn 28, Issue 1, 2004, Pages 52-56

  Pryme, Ian F ^a   Bardocz, Susan ^b   Pusztai, Arpad ^b   Ewen, Stanley W ^c   Pfüller, Uwe ^d  

^a UNIVERSITY OF BERGEN   (Norway)

^b ROWETT RESEARCH INSTITUTE   (United Kingdom)

^c UNIVERSITY OF ABERDEEN   (United Kingdom)

^d UNIVERSITY OF WITTEN HERDECKE   (Germany)

Author keywords

Anti angiogenesis; Anti cancer; Apoptosis; Cytokines; Gut hyperplasia; Mistletoe lectin; Peyer's patch

Indexed keywords

ANIMAL; APOPTOSIS; ARTICLE; COMPARATIVE STUDY; DIET; DISEASE MODEL; DRUG EFFECT; FEMALE; FETAL WELL BEING; METHODOLOGY; MORTALITY; MOUSE; MOUSE STRAIN; NEOVASCULARIZATION (PATHOLOGY); NONHODGKIN LYMPHOMA; PATHOLOGY; PHYTOTHERAPY; RANDOMIZATION; REFERENCE VALUE; SURVIVAL RATE; VISCUM ALBUM;

ANIMALS; APOPTOSIS; DIET; DISEASE MODELS, ANIMAL; FEMALE; FETAL VIABILITY; LYMPHOMA, NON-HODGKIN; MICE; MICE, INBRED STRAINS; MISTLETOE; NEOVASCULARIZATION, PATHOLOGIC; PHYTOTHERAPY; RANDOM ALLOCATION; REFERENCE VALUES; SURVIVAL RATE;

EID: 3142676480     PISSN: 0361090X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cdp.2003.10.003     Document Type: Article

References (29)

1. Pusztai A., Ewen S.W.B., Grant G.et al. Relationship between survival and binding of plant lectins during small intestinal passage and their effectiveness as growth factors. Digestion. 46(Suppl. 2):1990;308-316.
2. Eifler R, Pfüller K, Göckeritz W, et al. Improved procedures for isolation of mistletoe lectins and their subunits: lectin pattern of the European mistletoe. In: Basu J, Kundu M, Chakrabarty P, editors. Lectins: biology, biochemistry, clinical biochemistry, vol. 9. New Delhi: Wiley Eastern Limited; 1993. p. 144-51.
3. Hajto T., Hostanska K., Gabius H.J. Modulatory potency of the beta-galactoside-specific lectin from mistletoe extract (Iscador) on the host defense system in vivo in rabbits and patients. Cancer Res. 49:1989;4803-4808.
4. Stein G., Berg P. Modulation of cellular and humoral immune responses during exposure of healthy individuals to an aqueous mistletoe extract. Eur. J. Med. Res. 3:1998;307-314.
5. Heiny B.M., Albrecht V., Beuth J. Correlation of immune cell activities and beta-endorphin release in breast carcinoma patients treated with galactose-specific lectin standardized mistletoe extract. Anticancer Res. 18:1998;583-586.
6. Baxevanis C.N., Voutsas I.F., Soler M.H.J.et al. Mistletoe lectin I-induced effects on human cytotoxic lymphocytes. I. Synergism with IL-2 in the induction of enhanced LAK cytotoxicity. Immunopharmacol. Immunotoxicol. 20:1998;355-372.
7. Schink M. Mistletoe therapy for human cancer: the role of the natural killer cells. Anticancer Drugs. 8:1997;S47-S51.
8. Gabius S., Joshi S.S., Kayser K.et al. The galactoside-specific lectin from mistletoe as biological response modifier. Int. J. Oncol. 1:1992;705-708.
9. Pryme I.F., Bardocz S., Pusztai A. A diet containing the lectin phytohaemagglutinin (PHA) slows down the proliferation of Krebs II cell tumours in mice. Cancer Lett. 76:1994;133-137.
10. Bardocz S., Grant G., Duguid T.J.et al. Effect of phytohaemagglutinin on the growth of Krebs II tumour cells, body metabolism and internal organs of mice. Int. J. Oncol. 5:1994;1369-1374.
11. Pryme I.F., Pusztai A., Bardocz S. The initial growth rate of Krebs II ascites cell tumours in mice is slowed down by the inclusion of phytohaemagglutinin in the diet. Int. J. Oncol. 5:1994;1105-1107.
12. Bardocz S., Grant G., Duguid T.J.et al. Phytohaemagglutinin in the diet induces growth of the gut and modifies some organ weights in mice. Med. Sci. Res. 22:1994;101-103.
13. Pryme I.F., Bardocz S., Grant G.et al. Switching between control and phytohaemagglutinin-containing diets affects growth of Krebs II ascites cells and produces differences in the levels of putrescine, spermidine and spermine. Cancer Lett. 93:1995;233-237.
14. Pryme I.F., Pusztai A., Grant G.et al. Phytohaemagglutinin induced gut hyperplasia and the growth of a mouse lymphosarcoma tumour. J. Exp. Ther. Oncol. 1:1996;171-176.
15. Pryme IF, Bardocz S, Grant G, et al. The plant lectins PHA and ML-I suppress the growth of a lymphosarcoma tumour in mice. In: Bardocz S, Pfüller U, Pusztai A, editors. Effects of antinutrients on the nutritional value of legume diets COST 98, vol. 5. Luxembourg: EC Publication; 1998. p. 215-20.
16. Pryme I.F., Pusztai A., Grant G.et al. The induction of gut hyperplasia by phytohaemagglutinin in the diet and limitation of tumour growth. Histol. Histopathol. 13:1998;575-583.
17. Pryme I.F., Pusztai A., Bardocz S. A combination of dietary protein depletion and PHA-induced gut growth reduce the mass of a murine non-Hodgkin lymphoma. Cancer Lett. 139:1999;145-152.
18. Pryme I.F., Bardocz S., Pusztai A.et al. The growth of an established murine non-Hodgkin lymphoma tumour is limited by switching to a phytohaemagglutinin-containing diet. Cancer Lett. 146:1999;87-91.
19. Pryme IF, Grant G, Pusztai A, et al. Limiting the availability of polyamines for a developing tumour: an alternative approach to reducing tumour growth. In: Bardocz S, White A, editors. Polyamines in health and nutrition. Boston/Dordrecht/London: Kluwer Academic Publishers; 1999. p. 241-58.
20. Pryme IF, Pusztai A, Bardocz S, et al. Dietary phytohaemagglutinin reduces growth of a murine non-Hodgkin lymphoma. In: Johnson IT, Fenwick GR, editors. Dietary anticarcinogens and antimutagens: chemical and biological aspects. UK: Athenaeum Press Ltd.; 2000. p. 350-54.
21. Pryme I.F., Pusztai A., Grant G.et al. Dietary phytohaemagglutinin slows down the proliferation of a mouse plasmacytoma (MPC-11) tumour in Balb/c mice. Cancer Lett. 103:1996;151-155.
22. Pryme I.F., Bardocz S., Pusztai A.et al. Dietary mistletoe lectin supplementation and reduced growth of a murine non-Hodgkin lymphoma. Histol. Histopathol. 17:2002;261-271.
23. Pryme I.F., Bardocz S. Anti-cancer therapy: diversion of polyamines in the gut. Eur. J. Gastroenterol. Hepatol. 13:2001;1-6.
24. Klein G., Klein E. The transformation of a solid transplantable mouse carcinoma into an ascites tumor. Cancer Res. 11:1951;466-469.
25. Ewen SW, Pryme IF, Bardocz S, et al. Does oral ingestion of ML-I lectin ablate murine transplanted non-Hodgkin lymphoma by apoptosis or necrosis? In: Bardocz S, Hajos G, Pusztai A, editors. Effects of antinutrients on the nutritional value of legume diets, COST 98, vol. 6. Luxembourg: EC Publication; 1999. p. 126-33.
26. Ewen SW, Bardocz S, Grant G, et al. The effects of PHA and mistletoe lectin binding to epithelium of rat and mouse gut. In: Bardocz S, Pfüller U, Pusztai A, editors. Effects of antinutrients on the nutritional value of legume diets, COST 98, vol. 5. Luxembourg: EC Publication; 1998. p. 221-5.
27. Pusztai A., Grant G., Gelencsér E.et al. Effects of an orally administered mistletoe (type-2 RIP) lectin on growth. J. Nutr. Biochem. 9:1998;31-36.
28. Mannel D.N., Becker H., Gundt A.et al. Induction of tumour necrosis factor expression by a lectin from Viscum album. Cancer Immunol. Immunother. 33:1991;177-182.
29. Yoon T.J., Yoo Y.C., Choi O.B.et al. Inhibitory effect of Korean mistletoe (Viscum album coloratum) extract on tumor angiogenesis and of hematogenous and non-hematogenous tumor cells in mice. Cancer Lett. 97:1995;83-91.