Adjuvant intravesical treatment of superficial bladder cancer with a standardized mistletoe extract

Journal of Urology

Volumn 174, Issue 1, 2005, Pages 76-79

  Elsässer Beile, Ursula ^a   Leiber, Christian ^a   Wolf, Philipp ^a   Lucht, Martin ^a   Mengs, Ulrich ^b   Wetterauer, Ulrich ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

^b Madaus AG   (Germany)

Author keywords

Administration, intravesical; Bladder; Bladder neoplasms; Lectins; Mistletoe

Indexed keywords

BCG VACCINE; CYTOKINE; TUMOR NECROSIS FACTOR RECEPTOR; VISCUM ALBUM LECTIN;

ADULT; AGED; ARTICLE; BLADDER CANCER; CANCER ADJUVANT THERAPY; CANCER GRADING; CANCER RECURRENCE; CANCER STAGING; CLINICAL ARTICLE; CLINICAL TRIAL; CYSTOSCOPY; CYTOKINE PRODUCTION; DRUG EFFICACY; DRUG TOLERABILITY; FEMALE; FOLLOW UP; HUMAN; MALE; PHASE 1 CLINICAL TRIAL; PHASE 2 CLINICAL TRIAL; PRIORITY JOURNAL; SUPERFICIAL CANCER; TUMOR BIOPSY; URINE CYTOLOGY;

EID: 20444451208     PISSN: 00225347     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.ju.0000163261.08619.d0     Document Type: Article

References (17)

1. Kurth, K. H., Bouffioux, C., Sylvester, R., van der Meijden, A. P., Oosterlinck, W. and Brausi, M.: Treatment of superficial bladder tumors: achievements and needs. The EORTC Genitourinary Group. Eur Urol, suppl., 37: 1, 2000
2. Amling, C. L.: Diagnosis and management of superficial bladder cancer. Curr Probl Cancer, 25: 219, 2001
3. Deresiewicz, R. L., Stone, R. M. and Aster, J. C.: Fatal disseminated mycobacterial infection following intravesical bacillus Calmette-Guerin. J Urol, 144: 1331, 1990
4. Lamm, D. L., van der Meijden, A. P. M., Morales, A., Brosman, S. A., Catalona, W. J., Herr, H. W. et al: Incidence and treatment of complications of bacillus Calmette-Guerin intravesical therapy in superficial bladder cancer. J Urol, 147: 596, 1992
5. Ernst, E., Schmidt, K. and Steuer-Vogt, M. K.: Mistletoe for cancer? A systematic review of randomised clinical trials. Int J Cancer, 107: 262, 2003
6. Kienle, G. S., Berrino, F., Bussing, A., Portalupi, E., Rosenzweig, S. and Kiene, H.: Mistletoe in cancer-a systematic review on controlled clinical trials. Eur J Med Res, 8: 109, 2003
7. Hajto, T., Hostanska, K. and Gabius, H. J.: Modulatory potency of the beta-galactoside-specific lectin from mistletoe extract (Iscador) on the host defense system in vivo in rabbits and patients. Cancer Res, 49: 4803, 1989
8. Hajto, T., Hostanska, K., Frei, K., Rordorf, C. and Gabius, H. J.: Increased secretion of tumor necrosis factors alpha, interleukin 1, and interleukin 6 by human mononuclear cells exposed to beta-galactoside-specific lectin from clinically applied mistletoe extract. Cancer Res, 50: 3322, 1990
9. Mengs, U., Gothel, D. and Leng-Peschlow, E.: Mistletoe extracts standardized to mistletoe lectins in oncology: review on current status of preclinical research. Anticancer Res, 22: 1399, 2002
10. Mengs, U., Schwarz, T., Bulitta, M. and Weber, K.: Antitumoral effects of an intravesically applied aqueous mistletoe extract on urinary bladder carcinoma MB49 in mice. Anticancer Res, 20: 3565, 2000
11. Vang, O., Larsen, K. P. and Bøg-Hansen, T. C.: A New Quantitative and Highly Specific Assay for Lectin-Binding Activity. Berlin: W. de Gruyter, pp. 637-644, 1986
12. Elsasser-Beile, U., von Kleist, S. and Gallati, H.: Evaluation of a test system for measuring cytokine production in human whole blood cell cultures. J Immunol Methods, 139: 191, 1991
13. Elsasser-Beile, U., Ruhnau, T., Freudenberg, N., Wetterauer, U. and Mengs, U.: Antitumoral effect of recombinant mistletoe lectin on chemically induced urinary bladder carcinogenesis in a rat model. Cancer, 91: 998, 2001
14. Böhle, A. and Brandau, S.: Immune mechanisms in bacillus Calmette-Guerin immunotherapy for superficial bladder cancer. J Urol, 170: 964, 2003
15. Magno, C., Melloni, D., Gali, A., Mucciardi, G., Nicocia, G., Morandi, B. et al: The anti-tumor activity of bacillus Calmette-Guerin in bladder cancer is associated with an increase in the circulating level of interleukin-2. Immunol Lett, 81: 235, 2002
16. Taniguchi, K., Koga, S., Nishikido, M., Yamashita, S., Sakuragi, T., Kanetake, H. et al: Systemic immune response after intravesical instillation of bacille Calmette-Guerin (BCG) for superficial bladder cancer. Clin Exp Immunol, 115: 131, 1999
17. Elsässer-Beile, U., Gutzeit, O., Bauer, S., Katzenwadel, A., Schultze-Seemann, W. and Wetterauer, U.: Systemic and local immunomodulatory effects of intravesical BCG therapy in patients with superficial urinary bladder carcinomas. J Urol, 163: 296, 2000