Mistletoe lectin I-induced effects on human cytotoxic lymphocytes. I. Synergism with IL-2 in the induction of enhanced LAK cytotoxicity

Immunopharmacology and Immunotoxicology

Volumn 20, Issue 3, 1998, Pages 355-372

  Baxevanis, Constantin N ^a   Voutsas, Ioannis F ^a   Soler, Montserrat Huguet ^b   Gritzapis, Angelos D ^a   Tsitsilonis, Ourania E ^a   Stoeva, Stanka ^b   Voelter, Wolfgang ^b   Arsenis, Paula ^a   Papamichail, Michail ^a  

^a SAINT SAVVAS HOSPITAL   (Greece)

^b UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BETA GALACTOSIDE; CD14 ANTIGEN; CD4 ANTIGEN; CD56 ANTIGEN; CD8 ANTIGEN; INTERLEUKIN 2; VISCUM ALBUM LECTIN;

ARTICLE; CYTOTOXIC T LYMPHOCYTE; CYTOTOXICITY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; LYMPHOKINE ACTIVATED KILLER CELL; MONOCYTE; NATURAL KILLER CELL; PRIORITY JOURNAL; T LYMPHOCYTE;

VISCUM ALBUM;

EID: 0031661236     PISSN: 08923973     EISSN: None     Source Type: Journal    
DOI: 10.3109/08923979809034819     Document Type: Article

References (28)

1. Baxevanis, C.N. and Papamichail M. Characterization of the anti-tumor immune response in human cancers and strategies for immunotherapy. Crit. Rev. Oncol. Hematol. 16:157, 1994.
2. Baxevanis, C.N., Dedoussis, G.V.Z., Gritzapis, A.D., Stathopoulos, G.P. and Papamichail, M. Interleukin 1 synergizes with interleukin 2 in the outgrowth of autologous tumor-reactive CD8+ effectors. Brit. J. Cancer 70:625, 1994.
3. Heslop, H.E. Cytokine gene transfer in the therapy of malignancy. Baill. Clin. Haematol. 7:135, 1994.
4. Ettinghausen, S.E. and Rosenberg, S.A. Immunotherapy and gene therapy of cancer. Adv. Surg. 28:223, 1995.
5. Franz, H. Biological activities of mistletoe lectin (ML-I) and its A and B chains. In: Lectins: Biology, Biochemistry, Clinical Biochemistry. pp. 463-472, edited by Bog-Hausen T.C. and Breborowicz J., Walter de Gruyter & Co, Berlin, New York, 1985.
6. Franz, H., Ziska, P. and Kindt, A. Isolation and properties of three lectins from mistletoe (Viscum album L.). Biochem. J. 195:481, 1981.
7. Franz, H., Ziska, P. and Kindt, A. Simple method for the preparation of the two different chains of the mistletoe lectin I. In: Lectins: Biology, Biochemistry, Clinical Biochemistry. pp. 171-176, edited by Bog-Hausen T.C. and Breborowicz J., Walter de Gruyter & Co, Berlin, New York, 1982.
8. Gabius, H.J., Walzel, H., Joshii, S.S., Kojima, S., Gerke, V., Kratzim, H., et al. The immunomodulatory β-galactoside-specific lectin from mistletoe: partial sequence analysis, cell and tissue binding and impact on intercellular biosignalling of monocytic leukemia cells. Anticancer Res. 12:669, 1992.
9. Beuth, J., Ko, H.L., Gabius, H.J., Burrichter, H., Oette, K. and Pulverer, G. Behavior of lymphocyte subsets and expression of activation markers in response to immunotherapy with galactoside-specific lectin from mistletoe in cancer patients. Clin. Investig. 70:658, 1992.
10. Beuth, J., Ko, H.L., Tunggal, L., Steuer, M.K., Geisel, J., Jeljaszewicz, J. et al. Thymocyte proliferation and maturation in response to galactoside-specific mistletoe lectin-I. In vivo 7:407, 1993.
11. Beuth, J., Stoffel, B., Ko, H.L., Buss, G., Tunggel, L. and Pulverer, G. Immunoactive effects of various mistletoe lectin-I dosages in mammary carcinoma patients. Artzneimittelforschung 45:505, 1995.
12. Heiny, B.M. and Beuth, J. Mistletoe extract standardized from the galactoside-specific lectin (ML-I) induces β-endorphin release and immunopotentiation in breast cancer patients. Anticancer Res. 14:1339, 1994.
13. Ziska, P., Franz, H. and Kindt, A. The lectin from Viscum album L. Purification by biospecific affinity chromatography. Experientia 34:123, 1978.
14. Laemmli, U.K. Cleavage of structural proteins during the assembly of the head of Bacteriophage T4. Nature 227:680, 1970.
15. Baxevanis, C.N., Dedoussis, G.V.Z., Papadopoulos, N.G., Missitzis, I., Beroukas, C., Stathopoulos, G.P. et al. Enhanced human lymphokine-activated killer cell function after brief exposure to granulocyte-niacrophage colony-stimulating factor. Cancer 76:1253, 1995.
16. Baxevanis, C.N., Reclos G.J., Gritzapis, A.D., Dedoussis, G.V.Z., Missitzis, I. and Papamichail, M. Elevated prostaglandin E2 production by monocytes is responsible for the depressed levels of natural killer and lymphokine-activated killer cell function in patients with breast cancer. Cancer 72:491, 1993.
17. Sarri, C., Baxevanis, C.N., Cote, G.B., Reclos, G.J., Sarafidou, E., Spanos, T., et al. Sister chromatide exchange in highly purified human CD4+ and CD8+ lymphocytes. Mutation Res. 270:125, 1992.
18. Baxevanis, C.N., Dedoussis, G.V.Z., Papadopoulos, N.G., Missitzis, I., Stathopoulos, G.P. and Papamichail, M. Tumor-specific cytolysis by tumor-infiltrating lymphocytes in breast cancer. Cancer 74:1275, 1994.
19. Ioannides, C.G. and Whiteside, T.L. T cell recognition of human tumors: Implications for molecular immunotherapy of cancer. Clin. Immunol. Immunopathol. 2:91, 1993.
20. Heo, D.S., Whiteside, T.L., Kanbour, A. and Herberman, R.B. Lymphocytes infiltrating human ovarian tumors. I. Role of Leu 19 (NKH1)-positive recombinant IL2-activated cultures of lymphocytes infiltrating human ovarian tumors. J. Immunol. 140:4042, 1988.
21. Ioannides, C.G., Platsoukas, C.D., Rashed, S., Wharton, J.T., Creighton, L.E. and Freedman, R.S. Tumor cytolysis by lymphocytes infiltrating ovarian malignant ascites. Cancer Res. 51:4257, 1991.
22. Stein, G.M. and Berg, P.A. Evaluation of the stimulatory activity of a fermented mistletoe lectin-I free mistletoe extract on T-helper cells and monocytes in healthy individuals in vitro. Artzneimittelforschung 46:635, 1996.
23. Brenner, M.B., McLean, J., Dialynas, D.P., Strominger, J.L., Smith, J.A., Owen, F.L., Seidman, J.G., et al. Identification of putative T-cell receptor. Nature 322:145, 1986.
24. Borst, J.R., van de Griend, R., Oostreen, J.W., Ang, S.L., Melief, C.J., Seidman, J.G. et al. A T-cell receptor γ/CD3 complex found on cloned functional lymphocytes. Nature 325:683, 1987.
25. Chen, B.P., Hank, J.A., Kraus, E.E. and Sondel, P.M. Selective lysis of target cells by interleukin-2 expanded peripheral blood leukocyte clones. Cell. Immunol. 118:458, 1989.
26. Bachelez, H., Flageul, B., Depos, L., Boumsell, L. and Bensussan, A. TCR gamma delta bearing T lymphocytes infiltrating human primary cutaneous melanomas. J. Invest. Dermatol. 98:369, 1992.
27. Nanno, M., Hidetoschi, S., Mathioudakis, G., Suzuki, R., Itoh, K., Ioannides, C.G., et al. γ/δ T cell antigen receptors expressed on tumor-infiltrating lymphocytes from patients with solid tumors. Eur. J. Immunol. 22:679, 1992.
28. Ioannides, C.G., Rashed, S., Fisk, B., Fan, D., Itoh, K. and Freedman, R.S. Lymphocytes infiltrating ovarian malignant ascites: Modulation of IL-2-induced proliferation by IL-4 and of selective increase in CD8+ T cells by TNF-α. Lymphokine Cytokine Res. 10:307, 1991.