Dietary phytohaemagglutinin slows down the proliferation of a mouse plasmacytoma (MPC-11) tumour in Balb/c mice

Cancer Letters

Volumn 103, Issue 2, 1996, Pages 151-155

  Pryme, Ian F ^a   Pusztai, Arpad J ^b   Grant, George ^b   Bardocz, Susan ^b  

^a UNIVERSITY OF BERGEN   (Norway)

^b ROWETT RESEARCH INSTITUTE   (United Kingdom)

Author keywords

Hyperplasia; Lectin; MPC 11 cells; Phytohaemagglutinin; Plasmacytoma; Tumour growth

Indexed keywords

PHYTOHEMAGGLUTININ;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CANCER INHIBITION; CONTROLLED STUDY; DIET SUPPLEMENTATION; FEMALE; HYPERPLASIA; LIPOLYSIS; MOUSE; NONHUMAN; ORAL DRUG ADMINISTRATION; ORGAN WEIGHT; PLASMACYTOMA; PRIORITY JOURNAL; SMALL INTESTINE; TUMOR VOLUME;

EID: 0029869884     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/0304-3835(96)04206-1     Document Type: Article

References (18)

1. Bardocz, S., Grant, G., Duguid, T.J., Brown, D.S., Sakhri, M., Pusztai, A.J., Pryme, I.F., Mayer, D. and Wayß, K. (1994) Phytohaemagglutinin in the diet induces growth of the gut and modifies some organ weights in mice. Med. Sci. Res., 22, 101-103.
2. de Oliveira, J.T.A., Pusztai, A. and Grant, G. (1988) Changes in organs and tissues induced by feeding of purified kidney bean (Phaseolus vulgaris) lectins. Nutr. Res., 8, 943-947.
3. Pusztai, A.J., Grant, G., Brown, D.S., Ewen, S.W.B. and Bardocz, S. (1988) Phaseolus vulgaris toxin induces growth and the uptake of polyamines by the rat small intestine in vivo. Med. Sci. Res., 16, 1283-1284.
4. Bardocz, S., Grant, G., Ewen, S.W.B., Duguid, T.J., Brown, D.S., Englyst, K. and Pusztai, A.J. (1995) Reversible effect of phytohaemagglutinin on the growth and metabolism of rat gastrointestinal tract. Gut, 37, 353-360.
5. Bardocz, S., Brown, D.S., Grant, G. and Pusztai, A.J. (1990) Luminal and basolateral polyamine uptake by rat small intestine stimulated to grow by Phaseolus vulgaris lectin phytohaemagglutinin in vivo. Biochim. Biophys. Acta, 1034, 46-52.
6. Bardocz, S., Brown, D.S., Grant, G., Pusztai, A.J., Stewart, J.C. and Palmer, R.M. (1992) Effect of the α-adrenoreceptor agonist clenbuterol and phytohaemagglutinin on growth, protein synthesis and polyamine metabolism of tissues of the rat. Br. J. Pharmacol., 106, 476-482.
7. Pusztai, A.J. (1991) Plant Lectins, pp. 1-251. Cambridge University Press, Cambridge, UK.
8. Pusztai, A.J., Grant, G., Williams, L.M., Brown, D.S. and Bardocz, S. (1989) Phaseolus vulgaris lectin induces growth and the uptake of polyamines by the rat small intestine in vivo. Med. Sci. Res., 17, 215-217.
9. Bardocz, S., Grant, G., Brown, D.S., Ewen, S.W.B., Nevison, I. and Pusztai, A.J. (1990) Polyamine metabolism and uptake during Phaseolus vulgaris lectin, PHA-induced growth of the rat small intestine. Digestion, 46 (Suppl.), 360-366.
10. Pryme, I.F., Bardocz, S. and Pusztai, A.J. (1994) A diet containing the lectin phytohaemagglutinin (PHA) slows down the proliferation of Krebs II cell tumours in mice. Cancer Lett., 76, 133-137.
11. Pryme, I.F., Pusztai, A.J. and Bardocz, S. (1994) The initial growth rate of Krebs II ascites cell tumours in mice is slowed down by the inclusion of phytohaemagglutinin in the diet. Int. J. Oncol., 5, 1105-1107.
12. Bardocz, S., Grant, G., Duguid, T.J., Brown, D.S., Pusztai, A.J. and Pryme, I.F. (1994) Effect of phytohaemagglutinin on the growth of Krebs II tumour cells, body metabolism and internal organs of mice. Int. J. Oncol., 5, 1369-1374.
13. Pryme, I.F., Bardocz, S., Grant, G., Duguid, T.J., Brown, D.S. and Pusztai, A.J. (1995) Switching between control and phytohaemagglutinin containing diets affects growth of Krebs II ascites cells and produces differences in the levels of putrescine, spermidine and spermine. Cancer Lett., 93, 233-237.
14. Tabor, C.W. and Tabor, H. (1984) Polyamines. Annu. Rev. Biochem., 53, 749-790.
15. Pegg, A.E. (1986) Recent advances in the biochemistry of polyamines in eukaryotes. Biochem. J., 234, 240-262.
16. Bardocz, S. (1989) Polyamines in tissue regeneration. In: Physiology of Polyamines, Vol. 1, pp. 96-106. Editors. U. Bachrach and Y.M. Heimer. CRC Press, Boca Raton, FL.
17. Pryme, I.F. and Berg, B.H. (1991) The activities of aminoacyl-tRNA synthetase phosphatases and aminoacyl-tRNA synthetases in MPC-11 and Krebs II ascites cells. Cancer Lett., 58, 119-123.
18. Bardocz, S. (1993) The role of dietary polyamines (a review). Eur. J. Clin. Nutr., 47, 683-690.