Probabilistic regulation of IL-4 production

Journal of Clinical Immunology

Volumn 25, Issue 6, 2005, Pages 573-581

  Guo, Liying ^a   Hu Li, Jane ^a   Paul, William E ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

Chromatin; Cytokines; Green florescence protein; Monoallelism

Indexed keywords

IMMUNOGLOBULIN; INTERLEUKIN 13; INTERLEUKIN 2; INTERLEUKIN 4; TRANSCRIPTION FACTOR;

ALLELE; ANTIGEN EXPRESSION; ANTIGEN FUNCTION; CELL DIFFERENTIATION; CELL STIMULATION; CYTOKINE PRODUCTION; HUMAN; MACROPHAGE; PHENOTYPE; PRIORITY JOURNAL; PROBABILITY; PROTEIN EXPRESSION; REGULATORY MECHANISM; REVIEW; TH2 CELL;

ANIMALS; GENE EXPRESSION REGULATION; HUMANS; INTERLEUKIN-4; PROBABILITY; TH2 CELLS; TIME FACTORS;

EID: 29444461183     PISSN: 02719142     EISSN: 15732592     Source Type: Journal    
DOI: 10.1007/s10875-005-8218-5     Document Type: Review

References (33)

1. Poo WJ, Conrad L, Janeway CA, Jr: Receptor-directed focusing of lymphokine release by helper T cells. Nature 332:378-380, 1988
2. Hollander GA, Zuklys S, Morel C, Mizoguchi E, Mobisson K, Simpson S, Terhorst C, Wishart W, Golan DE, Bhan AK, Burakoff SJ: Monoallelic expression of the interleukin-2 locus. Science 279:2118-2121, 1998
3. Naramura M, Hu RJ, Gu H: Mice with a fluorescent marker for interleukin 2 gene activation. Immunity 9:209-216, 1998
4. Bix M, Locksley RM: Independent and epigenetic regulation of the interleukin-4 alleles in CD4+T cells. Science 281:1352-1354, 1998
5. Riviere I, Sunshine MJ, Littman DR: Regulation of IL-4 expression by activation of individual alleles. Immunity 9:217-228, 1998
6. Rhoades KL, Singh N, Simon I, Glidden B, Cedar H, Chess A: Allele-specific expression patterns of interleukin-2 and Pax-5 revealed by a sensitive single-cell RT-PCR analysis. Curr Biol 10:789-792, 2000
7. Bayley JP, Bakker AM, Kaijzel EL, Wierenga EA, van der Pouw-Kraan TC, Huizinga TW, Verweij CL: Analysis of allelic expression patterns of IL-2, IL-3, IL-4, and IL-13 in human CD4+ T cell clones. Eur J Immunol 33:2142-2148, 2003
8. Pannetier C, Hu-Li J, Paul WE: Bias in the expression of IL-4 alleles: The use of T cells from a GFP knock-in mouse. Cold Spring Harb Symp Quantum Biol 64:599-602, 1999
9. Hu-Li J, Pannetier C, Guo L, Lohning M, Gu H, Watson CJ, Assenmacher M, Radbruch A, Paul WE: Regulation of expression of IL-4 alleles: Analysis using a chimeric GFP/IL-4 gene. Immunity 14:1-11, 2001
10. Guo L, Hu-Li J, Paul WE: Probabilistic regulation of IL-4 production in Th2 cells: Accessibility at the 114 locus. Immunity 23:89-99,2005
11. Guo L, Hu-Li J, Paul WE: Probabilistic regulation in Th2 cells accounts for monoallelic expression of IL-4 and IL-13. Immunity 20:193-203, 2004
12. Loots GG, Locksley RM, Blankespoor CM, Wang ZE, MiUer W, Rubin EM, Frazer KA: Identification of a coordinate regulator of interleukins 4, 13, and 5 by cross-species sequence comparisons. Science 288:136-140, 2000
13. Agarwal S, Rao A: Modulation of chromatin structure regulates cytokine gene expression during T cell differentiation. Immunity 9:765-775, 1998
14. Agarwal S, Avni O, Rao A: Cell-type-restricted binding of the transcription factor NFAT to a distal IL-4 enhancer in vivo. Immunity 12:643-652, 2000
15. Takemoto N, Koyano-Nakagawa N, Yokota T, Arai N, Miyatake S, Arai K: T(h)2-specific DNase I-hypersensitive sites in the murine IL-13 and IL-4 intergenic region. Intl Immunology 10:1981-1985, 1998
16. Zhu J, Cote-Sierra I, Guo L, Paul WE: Stat5 activation plays a critical role in Th2 differentiation. Immunity 19:739-748, 2003
17. Guo L, Hu-Li J, Zhu J, Watson CJ, Difilippantonio MJ, Pannetier C, Paul WE: In TH2 cells the Il4 gene has a series of accessibility states associated with distinctive probabilities of IL-4 production. Proc Natl Acad Sci USA 99:10623-10628, 2002
18. Lee GR, Fields PE, Griffin TJ, Flavell RA: Regulation of the Th2 cytokine locus by a locus control region. Immunity 19:145-153, 2003
19. Fields PE, Lee GR, Kim ST, Bartsevich VV, Flavell RA: Th2-specific chromatin remodeling and enhancer activity in the Th2 cytokine locus control region. Immunity 21:865-876, 2004
20. Mohrs M, Blankespoor CM, Wang ZE, Loots GG, Afzal V, Hadeiba H, Shinkai K, Rubin EM, Locksley RM: Deletion of a coordinate regulator of type 2 cytokine expression in mice. Nat Immuno 2:842-847, 2001
21. Paul WE: Interleukin-4: A prototypic immunoregulatory lymphokine. Blood 77:1859-1870, 1991
22. Wynn TA: IL-13 effector functions. Annu Rev Immunol 21:425-456, 2003
23. Vitetta ES, Ohara J, Myers C, Layton J, Krammer PH, Paul WE: Serologic, biochemical and functional identity of B cell stimulatory factor-1 and B cell differentiation factor for IgG1. J Exp Med 162:1726-1731, 1985
24. Gascan H, Gauchat JF, Roncarolo MG, Yssel H, Spits H, DeVries JE: Human B-cell clones can be induced to proliferate and to switch to IgE and IgG4 synthesis by interleuin-4 and a signal provided by activated CD4+ T-cell clones. J Exp Med 173:747-750, 1991
25. Coffman RL, Ohara J, Bond MW, Carty J, Zlotnik A, Paul WE: B cell stimulatory factor-1 enhances the IgE response of lipopolysaccharide-activated B cells. J Immunol 136:4538-4541, 1986
26. Skuse DH: X-linked genes and mental functioning. Hum Mol Gene 14:R27-R32, 2005
27. Jung D, Alt FW: Unraveling V(D)J recombination: Insights into gene regulation. Cell 116:299-311, 2004
28. Krangel MS: Gene segment selection in V(D)J recombination: Accessibility and beyond. Nat Immunol 4:624-630, 2003
29. Wilkins JF, Haig D: What good is genomic imprinting: The function of parent-specific gene expression. Nat Rev 4:1-10, 2003
30. Goren A, Cedar H: Replicating by the clock. Nat Rev Mol Cell Biol 4:25-32, 2003
31. Simon I, Tenzen T, Reubinoff BE, Hillman D, McCarrey JR, Cedar H: Asynchronous replication of imprinted genes is established in the gametes and maintained during development. Nature 401:929-932, 1999
32. Mostoslavsky R, Singh N, Tenzen T, Goldmit M, Gabay C, Elizur S, Qi PM, Reubinoff BE, Chess A, Cedar H, Bergman Y: Asynchronous replication and allelic exclusion in the immune system. Nature 414:221-225, 2001
33. Singh N, Ebrahimi FA, Gimelbrant AA, Ensminger AW, Tackett MR, Qi P, Gribnau J, Chess A: Coordination of the random asynchronous replication of autosomalloci. Nat Genet 33:339-341, 2003