Human neutrophil defensins and secretory leukocyte proteinase inhibitor in squamous metaplastic epithelium of bronchial airways

Inflammation Research

Volumn 53, Issue 6, 2004, Pages 230-238

  Aarbiou, J ^a   Van Schadewijk, A ^a   Stolk, J ^a   Sont, J K ^a   De Boer, W I ^a   Rabe, K F ^a   Van Krieken, J H J M ^b   Mauad, T ^a   Hiemstra, P S ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Airway epithelium; Airways obstruction; Antimicrobial peptides; Proliferation; Squamous metaplasia

Indexed keywords

DEFENSIN; ELASTASE; PROTEINASE INHIBITOR;

ARTICLE; BRONCHUS MUCOSA; CELL PROLIFERATION; CHRONIC OBSTRUCTIVE LUNG DISEASE; CLINICAL ARTICLE; DATA ANALYSIS; EPITHELIUM CELL; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LEUKOCYTE; NEUTROPHIL; PHENOTYPE; SMOKING; SQUAMOUS CELL METAPLASIA;

ADULT; AGED; AGED, 80 AND OVER; BRONCHI; CARCINOMA, SQUAMOUS CELL; CELL PROLIFERATION; DEFENSINS; EPITHELIUM; FEMALE; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; IMMUNOHISTOCHEMISTRY; KI-67 ANTIGEN; MALE; METAPLASIA; MIDDLE AGED; NEOPLASM METASTASIS; NEUTROPHILS; PHENOTYPE; PROTEINASE INHIBITORY PROTEINS, SECRETORY; PROTEINS; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; SECRETORY LEUKOCYTE PEPTIDASE INHIBITOR; SKIN NEOPLASMS; SMOKING;

EID: 2942719123     PISSN: 10233830     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00011-003-1240-x     Document Type: Article

References (38)

1. Trevisani L, Sartori S, Bovolenta MR, Mazzoni M, Pazzi P, Putinati S et al. Structural characterization of the bronchial epithelium of subjects with chronic bronchitis and in asymptomatic smokers. Respiration 1992; 59: 136-44.
2. Vermylen P, Roufosse C, Ninane V, Sculier JP. Biology of pulmonary preneoplastic lesions. Cancer Treat Rev 1997; 23: 241-62.
3. Jeffery PK. Structural and inflammatory changes in COPD: a comparison with asthma. Thorax 1998; 53: 129-36.
4. Macnee W, Rahman I. Is oxidative stress central to the pathogenesis of chronic obstructive pulmonary disease? Trends Mol Med 2001; 7: 55-62.
5. Rutgers SR, Postma DS, ten Hacken NHT, Kauffman HF, van der Mark TW, Koeter GH et al. Ongoing airway inflammation in patients with COPD who do not currently smoke. Thorax 2000; 55: 12-8.
6. Grashoff WF, Sont JK, Sterk PJ, Hiemstra PS, de Boer WI, Stolk J et al. Chronic obstructive pulmonary disease: role of bronchiolar mast cells and macrophages. Am J Pathol 1997; 151: 1785-90.
7. Saetta M, Turato G, Facchini FM, Corbino L, Lucchini RE, Casoni G et al. Inflammatory cells in the bronchial glands of smokers with chronic bronchitis. Am J Respir Crit Care Med 1997; 156: 1633-9.
8. Saetta M, Di Stefano A, Maestrelli P, Ferraresso A, Drigo R, Potena A et al. Activated T-lymphocytes and macrophages in bronchial mucosa of subjects with chronic bronchitis. Am Rev Respir Dis 1993; 147: 301-6.
9. O'Shaughnessy TC, Ansari TW, Barnes NC, Jeffery PK. Inflammation in bronchial biopsies of subjects with chronic bronchitis: inverse relationship of CD8+ T lymphocytes with FEV1. Am J Respir Crit Care Med 1997; 155: 852-7.
10. Thompson AB, Daughton D, Robbins RA, Ghafouri MA, Oehlerking M, Rennard SI. Intraluminal airway inflammation in chronic bronchitis. Characterization and correlation with clinical parameters. Am Rev Respir Dis 1989; 140: 1527-37.
11. Stanescu D, Sanna A, Veriter C, Kostianev S, Calcagni PG, Fabbri LM et al. Airways obstruction, chronic expectoration, and rapid decline of FEV1 in smokers are associated with increased levels of sputum neutrophils. Thorax 1996; 51: 267-71.
12. Maestrelli P, Calcagni PG, Saetta M, Bertin T, Mapp CE, Sanna A et al. Integrin upregulation on sputum neutrophils in smokers with chronic airway obstruction. Am J Respir Crit Care Med 1996; 154: 1296-300.
13. Aarbiou J, Rabe KF, Hiemstra PS. Role of defensins in inflammatory lung disease. Ann Med 2002; 34: 96-101.
14. Murphy CJ, Foster BA, Mannis MJ, Selsted ME, Reid TW Defensins are mitogenic for epithelial cells and fibroblasts. J Cell Physiol 1993; 155: 408-13.
15. Aarbiou J, Ertmann M, van Watering S, Van Noort P, Rook D, Rabe KF et al. Human neutrophil defensins induce lung epithelial cell proliferation in vitro. J Leukoc Biol 2002; 72: 167-74.
16. Aarbiou J, Verhoosel RM, van Wetering S, de Boer WI, van Krieken JHJM, Lirvinov SV et al. Neutrophil defensins enhance lung epithelial wound closure and mucin gene expression in vitro. Am J Respir Cell Mol Biol 2004; 30: 193-201.
17. Hiemstra PS, Maassen RJ, Stolk J, Heinzel-Wieland R, Steffens GJ, Dijkman JH. Antibacterial activity of antileukoprotease. Infect Immun 1996; 64: 4520-4.
18. De Water R, Willems LN, Van Muijen GN, Franken C , Fransen JA, Dijkman JH et al. Ultrastructural localization of bronchial antileukoprotease in central and peripheral human airways by a gold-labeling technique using monoclonal antibodies. Am Rev Respir Dis 1986; 133: 882-90.
19. Asano S, Kida K, Koyama T, Wada H, Izawa Y, Hosoda K et al. A morphologic study of lung secretory leukoprotease inhibitor in pneumonia. Am J Respir Crit Care Med 1995; 151: 1576-81.
20. Ashcroft GS, Lei K, Jin W, Longenecker G, Kulkarni AB, Greenwell-Wild T et al. Secretory leukocyte protease inhibitor mediates non-redundant functions necessary for normal wound healing. Nat Med 2000; 6: 1147-53.
21. Devoogdt N, Hassanzadeh GG, Zhang J, Brys L, De Baetselier P, Revets H. Secretory leukocyte protease inhibitor promotes the tumorigenic and metastatic potential of cancer cells. Proc Natl Acad Sci USA 2003; 100: 5778-82.
22. Zhang D, Simmen RC, Michel FJ, Zhao G, Vale-Cruz D, Simmen FA. Secretory leukocyte protease inhibitor mediates proliferation of human endometrial epithelial cells by positive and negative regulation of growth-associated genes. J Biol Chem 2002; 277: 29999-30009.
23. Zhu J, Nathan C, Jin W, Sim D, Ashcroft GS, Wahl SM et al. Conversion of proepithelin to epithelins: roles of SLPI and elastase in host defense and wound repair. Cell 2002; 111: 867-78.
24. van Wetering S, van der Linden AC, van Sterkenburg MA, de Boer WI, Kuijpers AL, Schalkwijk J et al. Regulation of SLPI and elafin release from bronchial epithelial cells by neutrophil defensins. Am J Physiol Lung Cell Mol Physiol 2000; 278: L51-8.
25. Sont JK, de Boer WI, Van Schadewijk WA, Grunberg K, Van Krieken JH, Hiemstra PS et al. Fully automated assessment of inflammatory cell counts and cytokine expression in bronchial tissue. Am J Respir Crit Care Med 2003; 167: 1496-503.
26. Blomqvist M, Bergquist J, Westman A, Hakansson K, Hakansson P, Fredman P et al. Identification of defensins in human lymphocyte nuclei. Eur J Biochem 1999; 263: 312-8.
27. Obata-Onai A, Hashimoto S, Onai N, Kurachi M, Nagai S, Shizuno K et al. Comprehensive gene expression analysis of human NK cells and CD8(+) T lymphocytes. Int Immunol 2002; 14: 1085-98.
28. Jetten AM, Vollberg TM, Nervi C. Hyperplasia and squamous metaplasia in the tracheobronchial epithelium: alterations in the balance of growth and differentiation factors. Adv Exp Med Biol 1992; 320: 89-93.
29. Rice WG, Ganz T, Kinkade JM, Jr., Selsted ME, Lehrer RI, Parmley RT. Defensin-rich dense granules of human neutrophils. Blood 1987; 70: 757-65.
30. Bosken CH, Hards J, Gatter K, Hogg JC. Characterization of the inflammatory reaction in the peripheral airways of cigarette smokers using immunocytochemistry. Am Rev Respir Dis 1992; 145: 911-7.
31. Qiu Y, Zhu J, Bandi V, Atmar R, Hattotuwa K, Guntapalli K et al. Biopsy neutrophilia, chemokine and receptor gene expression in severe exacerbations of COPD. Am J Respir Crit Care Med 2003; 168: 960-75.
32. Hunninghake GW, Crystal RG. Cigarette smoking and lung destruction. Accumulation of neutrophils in the lungs of cigarette smokers. Am Rev Respir Dis 1983; 128: 833-8.
33. Ameshima S, Ishizaki T, Demura Y, Imamura Y, Miyamori I, Mitsuhashi H. Increased secretory leukoprotease inhibitor in patients with nonsmall cell lung carcinoma. Cancer 2000; 89: 1448-56.
34. Willems LN, Kramps JA, Stijnen T, Sterk PJ, Weening JJ, Dijkman JH. Antileukoprotease-containing bronchiolar cells. Relationship with morphologic disease of small airways and parenchyma. Am Rev Respir Dis 1989; 139: 1244-50.
35. Gompertz S, Bayley DL, Hill SL, Stockley RA. Relationship between airway inflammation and the frequency of exacerbations in patients with smoking related COPD. Thorax 2001; 56: 36-41.
36. Sveger T, Ohlsson K, Polberger S, Noack G, Morse H, Laurin S. Tracheobronchial aspirate fluid neutrophil lipocalin, elastase- and neutrophil protease-4-alpha1-antitrypsin complexes, protease inhibitors and free proteolytic activity in respiratory distress syndrome. Acta Paediatr 2002; 91: 934-7.
37. Hendrixson DR, St GJ, III. The Haemophilus influenzae Hap serine protease promotes adherence and microcolony formation, potentiated by a soluble host protein. Mol Cell 1998; 2: 841-50.
38. Fink DL, St GJ, III. Chromosomal expression of the Haemophilus influenzae Hap autotransporter allows fine-tuned regulation of adhesive potential via inhibition of intermolecular autoproteolysis. J Bacteriol 2003; 185: 1608-15.